Protein Alignment Opa1 and eat-3

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_495986.3
• Gene: eat-3 / 174476
• WormBaseID: WBGene00001134
• Length: 964
• Species: Caenorhabditis elegans
• Alignment Length: 902
• Identity: 470/902 - (52%)
• Similarity: 628/902 - (69%)
• Gaps: 33/902 - (3%)

  Fly    87 RGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPNF---KWLEDAMPQGERWSQFSRNLIEVGSLV 148
            |..|||||.:..|.|||.|:....|||||..||:.   :|.:    ....|::||:.:    ..:
 Worm    79 RHLLKLRYFIATGVIGGSVAARTWYEEWKSNLPDLSLPEWFD----SNGSWNEFSQKM----KGI 135

  Fly   149 KNAIEVDPKLKQLGEDKLSEWR---NWFDSRLDD--AIEAADYQGVQIVETKDDLKAKTTVAALG 208
            |:....|      |::|.:||.   ..|..:.:|  ........|...|..|:.:...:.::|..
 Worm   136 KDGFGAD------GQNKWAEWMAKFEQFKQQKEDQNGNSGGGGGGEGNVPVKEPVILASLMSAFS 194

  Fly   209 ITSDESRKKYEKL--QSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKI 271
            ...||..:|.:.:  :.:::.||.|::..|.:||:|||::||||:.|:|:.|:.........|::
 Worm   195 SKKDEPEEKKDNVSAEERIQKLQEEMLKTQSQYQRELERLEKENKVLKQRLLLSDDKAAIRLKRL 259

  Fly   272 KKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRA 336
            |:|||||||||||.|:.||:.|..:|:|||||||||||:|||||||.:|:|||||||||||||||
 Worm   260 KRSLIDMYSEVLDLLNEYDSSYNTSDNLPRVVVVGDQSAGKTSVLEMVAQARIFPRGSGEMMTRA 324

  Fly   337 PVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPG 401
            ||||||:||||||||||||.||:|||||:|||.||.:.|.||:.|||.|||||||||::|||||.
 Worm   325 PVKVTLSEGPYHVAQFRDSSREFDLTKETDLQQLRNETEVRMRNSVRDGKTVSNEVISLTVKGPN 389

  Fly   402 LQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQC 466
            |.|||||||||:|||:|.|||.:|||.|.:|:|.:|.|||||||||||||||||||||||||...
 Worm   390 LPRMVLVDLPGVISTVTADMARETKDDIIRMSKAHMENPNAIILCIQDGSVDAERSNVTDLVSSI 454

  Fly   467 DPLGRRTIFVLTKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEE 530
            ||.|:|||.||||||:||: ||:||||:|||.|||||||||||:.||||||...||||.||:|||
 Worm   455 DPSGKRTILVLTKVDMAEKNLANPDRIKKILEGKLFPMKALGYFGVVTGRGNSSDSIDEIRKYEE 519

  Fly   531 DFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPR 595
            :||..|:|. |.||:.|.|:|:||:||||||.||:|||::||.|.|||:|.:||||.||||:|.|
 Worm   520 NFFSTSQLL-RDGVLKPSQMTTRNMSLAVSDCFWRMVRDSIESQTDAFRAAKFNLEAEWKNHFLR 583

  Fly   596 LRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSF 660
            :|:..||||:|||:||||||:|.||.|..::|:..|..|||..:|::||:.|.:||..|.|..||
 Worm   584 IRQLNRDELYDKARGEILDEIVNLSLIGVEEWEKLLQDKLWSGISSHVFDQILMPAYASSSSGSF 648

  Fly   661 NTMVDIKLRQWAEQALPAKSVEAGWEALQQEF---ISLMERSKKAQDHDGIFDQLKSAVVDEAIR 722
            ||.|||||:.:|::.|..||:|.||:.|::.|   |:...|:||  |||.:||.||.||::||:.
 Worm   649 NTTVDIKLKHFADKQLAQKSIETGWDTLKEVFFRQINQDARTKK--DHDPVFDALKEAVIEEAML 711

  Fly   723 RHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRI 787
            .|.|:|||:|.|||||||.:|||.|.||:.||:|..||..:.:.:|...::.|....|||...:.
 Worm   712 THGWDDKAMDYLRVIQLNAMEDRAVQDKRSWDAACNFLHKAASERLAAVKKQLTDDRGPGWASKW 776

  Fly   788 THWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNV-DVDTDYIRQTWFP 851
            ..|:..|.|......:::||..||..|.:|...||.|::|.:|:|::...| :|.|:.||:.|..
 Worm   777 LMWKTPTADNHYSCVIQDELYSILGADPEHKQALTDDDITVIRRNIETKGVLEVPTESIRKQWKL 841

  Fly   852 VYRKHFLQQALQRAKDCRKAYYLYTQQGAE-CEISCSDVVLFWRIQQVIKITGNALRQQVINREA 915
            |::||||::.:..:|||...|.:|.|...| .:|.|..:|||:|||:::.:|.||||||:.|.|.
 Worm   842 VFKKHFLERIINSSKDCLSMYQMYRQGMIEGQDIDCQTIVLFYRIQKMVNLTCNALRQQITNTEH 906

  Fly   916 RRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            |||:||||.|||::|.:.:.|...|||:||.||||:.:||:||||||||:..|.:||
 Worm   907 RRLEKEIKEVLDDWSQEPDIKKKYLTGRRVDLAEEIQQVRRIQEKLEEFMAQLQREK 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	205/274 (75%)
		OPA1_C	629..972	CDD:466080	156/347 (45%)
eat-3	NP_495986.3	CwlO1	195..>311	CDD:443091	56/115 (49%)
		DLP_1	286..560	CDD:206738	205/274 (75%)
		OPA1_C	616..963	CDD:466080	156/348 (45%)