Protein Alignment Opa1 and Dnm3

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_612547.1
• Gene: Dnm3 / 171574
• RGDID: 727949
• Length: 869
• Species: Rattus norvegicus
• Alignment Length: 792
• Identity: 175/792 - (22%)
• Similarity: 310/792 - (39%)
• Gaps: 155/792 - (19%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|.:....||::.|||.||:||:||||:.......||||| ::||.|
  Rat     7 EELIPLVNRLQDAFSA--LGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|.::|..........|.:|:..|.:.|..|.:
  Rat    69 LVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRHEIEAETDRVTGMNKGISSVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...:::..|.:||.:...:.|...|:...|..:.|
  Rat   130 LNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
  Rat   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYVGVV-NRSQKDIDGKKDIKAAMLA 254

  Fly   529 EEDFFKNSKLFH----RRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQA 575
            |..||.:...:.    |.|.  ||      |...::.:....:|:|              ||.:.
  Rat   255 ERKFFLSHPAYRHIADRMGT--PH------LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEV 311

  Fly   576 DAFK------ATR-----FNLETEWKNNFPRLRESGRD-----ELFDKAK-GEILDEVVTLSQIS 623
            :|||      .||     ..:..::..:|.:..|...|     ||...|| ..|..|......:.
  Rat   312 EAFKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVK 376

  Fly   624 AKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGW 685
            .:..:..|..::     :|..::|:  ..::|   ...:|..:|..::.:....:|  |||
  Rat   377 MEFNEKELRREI-----SYAIKNIH--GIRTGLFTPDMAFEAIVKKQIVKLKGPSL--KSV---- 428

  Fly   686 EALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDM------LRVIQLNTLE 743
            :.:.||.|:.::: :|:..:...:.::.:..|.:....|   |.|..|.      ::|..:||..
  Rat   429 DLVMQELINTVKKCTKRLANFPRLCEETERIVANHIRER---EGKTKDQVLLLIDIQVSYINTNH 490

  Fly   744 DRF------------VHDKQEWDSAVKFLESS---VNAKLVQTEETLAQMFGPGQMRRITHWQYL 793
            :.|            ||.|....:....|..|   |..|...|...:..|.|..:    .:|..|
  Rat   491 EDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSK----GYWFVL 551

  Fly   794 T--------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTD 843
            |        .|::|.:.....||.:...|       :||:..|.:.|...|.|:.:...:..|:.
  Rat   552 TAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQ 616

  Fly   844 YIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQV-------IKI 901
            ....:|         :.:|.||.......:....:..:.|....|..|..:::.:       :.|
  Rat   617 EDVDSW---------KASLLRAGVYPDKSFTENDENGQAENFSMDPQLERQVETIRNLVDSYMSI 672

  Fly   902 TGNALRQQV--------INREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQ 958
            ....:|..:        ||.....::.|:.|.|  :|.:::.          .|.||.::..|.:
  Rat   673 INKCIRDLIPKTIMHLMINNVKDFINSELLAQL--YSSEDQN----------TLMEESVEQAQRR 725

  Fly   959 EKLEEFINSLNQ 970
            :::.....:|.:
  Rat   726 DEMLRMYQALKE 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/295 (29%)
		OPA1_C	629..972	CDD:466080	68/397 (17%)
Dnm3	NP_612547.1	DYNc	6..245	CDD:197491	79/249 (32%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	64/315 (20%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		1/3 (33%)
		PH_dynamin	526..635	CDD:269958	24/121 (20%)
		GED	655..745	CDD:460495	14/95 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	752..869
		MISS	<753..841	CDD:318115