Protein Alignment Opa1 and Dnm2

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_006510036.1
• Gene: Dnm2 / 13430
• MGIID: 109547
• Length: 880
• Species: Mus musculus
• Alignment Length: 737
• Identity: 160/737 - (21%)
• Similarity: 295/737 - (40%)
• Gaps: 150/737 - (20%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:::.|..|  ..|.:....||::.|||.||:||:||||:.......||||| ::||.|
Mouse     7 EELIPLVNKLQDAFS--SIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|:::|..........|.:|...|.:.|..|.:
Mouse    69 LILQLIFSKTEYAEFLHCKSK----KFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...::|..:::||.:...::|...|:...|..:.|
Mouse   130 LNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Mouse   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVV-NRSQKDIEGKKDIRAALAA 254

  Fly   529 EEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLE---TEWK 590
            |..||.:...:..    |..::.:.:|...::.:....:||::.......::...:||   .|:|
Mouse   255 ERKFFLSHPAYRH----MADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEYK 315

  Fly   591 NNFP------------RLRESGRDELFDKAKGEILDEVVTLS-----------------QISAKK 626
            |..|            .:::.|.|  |:|......|:|.||.                 ::...:
Mouse   316 NFRPDDPTRKTKALLQMVQQFGVD--FEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKME 378

  Fly   627 WDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGWEAL 688
            :|:    |...:..:|..::|:  ..::|   ...:|..:|..::.:..|..|  |.|    :.:
Mouse   379 FDE----KDLRREISYAIKNIH--GVRTGLFTPDLAFEAIVKKQVVKLKEPCL--KCV----DLV 431

  Fly   689 QQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQE 752
            .||.||.:.: :.|...:..:.::.: .:|...||......|.    :::.|..:|..:::...|
Mouse   432 IQELISTVRQCTSKLSSYPRLREETE-RIVTTYIREREGRTKD----QILLLIDIEQSYINTNHE 491

  Fly   753 WDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRIT----------------------------- 788
              ..:.|      |....|||.:.     |..:|.|
Mouse   492 --DFIGF------ANCFYTEELVT-----GAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISL 543

  Fly   789 -------HWQYLT--------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRK 831
                   :|..||        .:::|.:.....||.:...|       .||:..:.:.|...|.|
Mouse   544 MKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYK 608

  Fly   832 NLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQ 896
            :|::..:..|:.....:|    :..||:..:...||..:     .:.||:......|..|..:::
Mouse   609 DLRQIELACDSQEDVDSW----KASFLRAGVYPEKDQAE-----NEDGAQENTFSMDPQLERQVE 664

  Fly   897 QVIKITGNALRQQVINREARRL 918
            .:..:..:.:  .:||:..|.|
Mouse   665 TIRNLVDSYV--AIINKSIRDL 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	83/277 (30%)
		OPA1_C	629..972	CDD:466080	57/345 (17%)
Dnm2	XP_006510036.1	DYNc	6..245	CDD:197491	79/249 (32%)
		Dynamin_M	215..498	CDD:460033	60/318 (19%)
		PH_dynamin	530..639	CDD:269958	17/112 (15%)
		GED	659..749	CDD:460495	5/28 (18%)
		PHA03247	<747..878	CDD:223021