Protein Alignment Opa1 and Drp1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_061512097.1
• Gene: Drp1 / 1279863
• VectorBaseID: AGAMI1_004795
• Length: 732
• Species: Anopheles gambiae
• Alignment Length: 738
• Identity: 168/738 - (22%)
• Similarity: 294/738 - (39%)
• Gaps: 161/738 - (21%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            ::||.:.:::.|.   ::|..:.|..||::||:|.|||||:||:||:......|||:| ::||.|
Mosquito     2 EALIPVVNKLQDV---FNTVGSDAIQLPQIVVLGSQSSGKSSVIESLVGRTFLPRGTG-IVTRRP 62

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKE------------SDLQDLRRDVEFRMKASVRGGKTVSN 390
            :.:.|...|....:.|.::......:|            :|..::|.::|..........|.:..
Mosquito    63 LVLQLVYTPLDDREHRSAEHGTVAVEEWGRFLHIKNKVFTDFDEIRSEIENETDRMAGANKGICP 127

  Fly   391 EVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAE 455
            |.|.:.:....:..:.|||||||......|...|.:..|..:...|:.|||:|||.:...:.|..
Mosquito   128 EPINLKIYSTKVVNLTLVDLPGITKVPVGDQPEDIEAQIKDLVLKYIENPNSIILAVTAANTDMA 192

  Fly   456 RSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD- 519
            .|....:....||.||||:.||||:||.:  |..|.| .||.|::.|:| ||...|: .|.::|
Mosquito   193 TSEALKMAKDVDPDGRRTLAVLTKLDLMD--AGTDAI-DILCGRVIPVK-LGIIGVM-NRSQQDI 252

  Fly   520 ---DSIDAIRQYEEDFFK-------------------NSKLFHRRGVIMPHQVTSRNLSLA---- 558
               .:||...:.|..:.:                   |..|.|.....:|...|..|:..:
Mosquito   253 MDKKTIDDQLRDEAAYLQRKYPTLATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNVMASQFQS 317

  Fly   559 --------VSDRFWKMVRETIEQQADAF----KATRFNLETEWKNNFPRLRESGRDELFDKAKGE 611
                    |:|:. :.:.:.|.:.|.|:    :.|..|:||.......|:     ..:|.:..|:
Mosquito   318 LLNSYGEDVTDKS-QCLLQIITKFASAYCSTIEGTSRNIETTELCGGARI-----CYIFHETFGK 376

  Fly   612 ILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQAL 676
            .||.:..|:.::......|:......:      .::::|      :.||..:|..::|:..:.:|
Mosquito   377 TLDSIHPLTGLTKMDILTAIRNATGPR------PALFVP------EVSFELLVKRQIRRLEDPSL 429

  Fly   677 PAKSVEAGWEALQQ-------EFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRH-SWEDKAIDM 733
              :.||...|.:|:       |....|.|..|.  |:.|.|     ||.:.:||. ...:..::.
Mosquito   430 --RCVELIHEEMQRIIQHCGTEVQQEMLRFPKL--HEKIVD-----VVTQLLRRRLPTTNCMVEN 485

  Fly   734 LRVIQL---NTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRR--------- 786
            |..|:|   ||....|..|.....|.:| .:|.....:.||....::.  ||..|:
Mosquito   486 LVQIELAYINTKHPDFHKDAALVPSLIK-TDSQDQWAIHQTGNPPSRR--PGSNRQLALVDKTGM 547

  Fly   787 --ITHWQYLTQDQQKRRSVKNE--------LDKILKNDTKHL--------------PTLTHDELT 827
              :.|.....|.||:::..:|.        |..||..:.:.:              .|.||..|:
Mosquito   548 LNLNHDAQQQQQQQQQQQQQNHVSEQPGGWLGSILPPNMEAMIGAPGSESGNSTASNTPTHGVLS 612

  Fly   828 ---------------TVRKNLQRDNVDVDT-DYIRQTWFPVYRK-----------HFLQQALQRA 865
                           :.||...::..|.|. :.:.:::|.:.||           |||...::..
Mosquito   613 PTKPVNLLPDVPMNHSSRKLTDKEQKDCDVIERLIKSYFYIVRKSIQDSVPKAIMHFLVNFVKDN 677

  Fly   866 KDCRKAYYLYTQQGAECEISCSD 888
            .......:||....|...::.||
Mosquito   678 LQSELVTHLYKSDSANELLNESD 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/320 (27%)
		OPA1_C	629..972	CDD:466080	64/331 (19%)
Drp1	XP_061512097.1	None