Protein Alignment Opa1 and Dnm3

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_006496664.1
• Gene: Dnm3 / 103967
• MGIID: 1341299
• Length: 873
• Species: Mus musculus
• Alignment Length: 808
• Identity: 177/808 - (21%)
• Similarity: 312/808 - (38%)
• Gaps: 175/808 - (21%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|.:....||::.|||.||:||:||||:.......||||| ::||.|
Mouse     7 EELIPLVNRLQDAFSA--LGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|.::|..........|.:|:..|.:.|..|.:
Mouse    69 LVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRHEIEAETDRVTGMNKGISSIPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...:::..|.:||.:...:.|...|:...|..:.|
Mouse   130 LNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Mouse   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYVGVV-NRSQKDIDGKKDIKAAMLA 254

  Fly   529 EEDFFKNSKLFH----RRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQA 575
            |..||.:...:.    |.|.  ||      |...::.:....:|:|              ||.:.
Mouse   255 ERKFFLSHPAYRHIADRMGT--PH------LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEV 311

  Fly   576 DAFK------ATR-----FNLETEWKNNFPRLRESGRD-----ELFDKAK-GEILDEVVTLSQIS 623
            :|||      .||     ..:..::..:|.:..|...|     ||...|| ..|..|......:.
Mouse   312 EAFKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVK 376

  Fly   624 AKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGW 685
            .:..:..|..::     :|..::|:  ..::|   ...:|..:|..::.:....:|  |||
Mouse   377 MEFNEKELRREI-----SYAIKNIH--GIRTGLFTPDMAFEAIVKKQIVKLKGPSL--KSV---- 428

  Fly   686 EALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDM------LRVIQLNTLE 743
            :.:.||.|:.::: :|:..:...:.::.:..|.:....|   |.|..|.      ::|..:||..
Mouse   429 DLVMQELINTVKKCTKRLANFPRLCEETERIVANHIRER---EGKTKDQVLLLIDIQVSYINTNH 490

  Fly   744 DRF------------VHDKQEWDSAVKFLESS---VNAKLVQTEETLAQMFGPGQMRRITHWQYL 793
            :.|            ||.|....:....|..|   |..|...|...:..|.|..:    .:|..|
Mouse   491 EDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSK----GYWFVL 551

  Fly   794 T--------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTD 843
            |        .|::|.:.....||.:...|       :||:..|    ..|.::|:.:|
Mouse   552 TAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFAL----FNTEQRNVYKD------- 605

  Fly   844 YIRQTWFPVYRKHFLQQALQRAKD--------CRKAYY---------LYTQQGAECEISCSDVVL 891
                     ||  ||:.|....:|        .|...|         ....:..:.|....|..|
Mouse   606 ---------YR--FLELACDSQEDVDSWKASLLRAGVYPDKSVGSNKTENDENGQAENFSMDPQL 659

  Fly   892 FWRIQQV-------IKITGNALRQQV--------INREARRLDKEIKAVLDEFSDDEEKKGYLLT 941
            ..:::.:       :.|....:|..:        ||.....::.|:.|.|  :|.:::......:
Mouse   660 ERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQL--YSSEDQNTLMEES 722

  Fly   942 GKRVLLAEELIKVRQIQEKLEEFINSLN 969
            .::....:|::::.|..::....|..:|
Mouse   723 AEQAQRRDEMLRMYQALKEALAIIGDIN 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/295 (29%)
		OPA1_C	629..972	CDD:466080	70/413 (17%)
Dnm3	XP_006496664.1	DYNc	6..245	CDD:197491	79/249 (32%)
		Dynamin_M	215..502	CDD:460033	64/315 (20%)
		PH_dynamin	526..635	CDD:269958	27/134 (20%)
		GED	659..749	CDD:460495	12/91 (13%)
		MISS	<757..845	CDD:318115