Protein Alignment CG8468 and Slc16a8

DIOPT Version :10

• Sequence 1: NP_610940.1
• Gene: CG8468 / 36577
• FlyBaseID: FBgn0033913
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_113932.2
• Gene: Slc16a8 / 65200
• RGDID: 69282
• Length: 490
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 137/643 - (21%)
• Similarity: 213/643 - (33%)
• Gaps: 238/643 - (37%)

  Fly    43 PPDSGWAWVVMVASFLCCTVIDGIVF----CSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAG 103
            |||.||.|||:.|    |.||.|..:    ...:...:|..:||...:..|:|||::.......|
  Rat    12 PPDGGWGWVVLGA----CFVITGFAYGFPKAVSVFFRELKRDFGAGYSDTAWVSSIMLAMLYGTG 72

  Fly   104 PFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFY 168
            |..|.:..|||.|||.:.|.:.|:....|:.||:.:..|:|..|||.|:|..:.:.|:::::|.|
  Rat    73 PLSSILVTRFGCRPVMLAGGLLASAGMILASFASRLLELYLTAGVLTGLGLALNFQPSLIMLGLY 137

  Fly   169 FEKWRALATGVAMCGSGVGTFVFAPLTKIL-LKSGWRYTLAIQGIIVLSCALFGLAFRPIQPITL 232
            ||:.|.||.|:|..||.|.....:||.::| .:.|||....:.|.::|.|...|...||
  Rat   138 FERRRPLANGLAAAGSPVFLSTLSPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRP------ 196

  Fly   233 SVTNEEGDEQEKKKLNGHGNTVAPTPQLHQAAFTKPLPEGRFAYSMPNSAHNTYMGASQRNHYPT 297
                                  .|.||        |.|:
  Rat   197 ----------------------PPGPQ--------PRPD-------------------------- 205

  Fly   298 AQEIFKGMNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTVGENEEEAEND 362
                                             |..|.|
  Rat   206 ---------------------------------PAPPGG-------------------------- 211

  Fly   363 NLLETEAKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDIFFSGSLTRIP 427
                                                .|.|.|
  Rat   212 ------------------------------------RARHRQ----------------------- 217

  Fly   428 QYQSQTSLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFL 492
                                                        :||..:.....||....:.||
  Rat   218 --------------------------------------------LLDLAVCTDRTFMVYMVTKFL 238

  Fly   493 TMMGFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKP--LWLNNFAL 555
            ..:|.|||...||:.||.||:.:..|..:||.:|.|:..||..||:|:....::|  .:|.:.||
  Rat   239 MALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDIVARPACGALAGLGRLRPHVPYLFSLAL 303

  Fly   556 TAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAA 620
            .|.|:..:.|....:..|...|.:.||:......||:..:.:..:|..:..:|.|.::|.:.:|.
  Rat   304 LANGLTDLISARARSYGTLVAFCIAFGLSYGMVGALQFEVLMATVGAPRFPSALGLVLLVEAVAV 368

  Fly   621 TFGSPIAGGLYVMTGSYNAAFYFAGGLILLSAFLCYPLTWVSRWEERRNEKLTPLPAA 678
            ..|.|.||.|.....:|...||.||..::|:.......|:..   :|.::.:.|.|:|
  Rat   369 LIGPPSAGRLVDALKNYEIIFYLAGSEVVLAGVFMAVTTYCC---QRCSKDIPPGPSA 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS_MCT_SLC16	49..>225	CDD:340910	59/180 (33%)
		MFS	<477..658	CDD:475125	53/182 (29%)
Slc16a8	NP_113932.2	2A0113	14..440	CDD:273325	135/641 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..490		3/5 (60%)
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O95907	426..460
		Basolateral sorting signal. /evidence=ECO:0000250|UniProtKB:O95907	461..480