Protein Alignment CG8468 and SLC16A14

DIOPT Version :10

• Sequence 1: NP_610940.1
• Gene: CG8468 / 36577
• FlyBaseID: FBgn0033913
• Length: 678
• Species: Drosophila melanogaster
• Sequence 2: NP_689740.2
• Gene: SLC16A14 / 151473
• HGNCID: 26417
• Length: 510
• Species: Homo sapiens
• Alignment Length: 641
• Identity: 151/641 - (23%)
• Similarity: 238/641 - (37%)
• Gaps: 190/641 - (29%)

  Fly    45 DSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVSAM 109
            |.||||:::::||....:|.|.....|::..:.:.||..|:...|:||||..|..|:.|||:...
Human    29 DGGWAWMMVLSSFFVHILIMGSQMALGVLNVEWLEEFHQSRGLTAWVSSLSMGITLIVGPFIGLF 93

  Fly   110 ANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRA 174
            .|..|.|...|.|.:..::.:.||.:|.:|.|||:.:||..|:|..|.|:||||::|.||:|.||
Human    94 INTCGCRQTAIIGGLVNSLGWVLSAYAANVHYLFITFGVAAGLGSGMAYLPAVVMVGRYFQKRRA 158

  Fly   175 LATGVAMCGSGVGTFVFAPLTKIL-LKSGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTNEE 238
            ||.|::..|:|.|||:...|.|.| .:.|||..:.|||.:.|:..:.|...||:.|      .:.
Human   159 LAQGLSTTGTGFGTFLMTVLLKYLCAEYGWRNAMLIQGAVSLNLCVCGALMRPLSP------GKN 217

  Fly   239 GDEQEKKKLNGHGNTVAPTPQLHQAAFTKPLPEGRFAYSMPNSAHNTYMGASQRNHYPTAQEIFK 303
            .::..:|.:.|                   ||           ||:|
Human   218 PNDPGEKDVRG-------------------LP-----------AHST------------------ 234

  Fly   304 GMNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTVGENEEEAENDNLLETE 368
                                                       :.:.:.|:.....|.|..|..|
Human   235 -------------------------------------------ESVKSTGQQGRTEEKDGGLGNE 256

  Fly   369 AKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDIFFSGSLTRIPQYQSQT 433
            .....:||:      ..|...|.|....|.......|..:.|.....:.::||       |....
Human   257 ETLCDLQAQ------ECPDQAGHRKNMCALRILKTVSWLTMRVRKGFEDWYSG-------YFGTA 308

  Fly   434 SLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGFF 498
            |                                          |..:..|:...|........|.
Human   309 S------------------------------------------LFTNRMFVAFIFWALFAYSSFV 331

  Fly   499 VPFTFLVDRAKAAGMDEQ-AAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLW----LNNFAL--- 555
            :||..|.:......:.|| ..:.:.|.|.:|:.|.:::.|.::..|.:. :|    |.||.|
Human   332 IPFIHLPEIVNLYNLSEQNDVFPLTSIIAIVHIFGKVILGVIADLPCIS-VWNVFLLANFTLVLS 395

  Fly   556 --------TAGGIATICSGIVINTATQWTFALFFGICIACFSALRSLIAVELIGLEKLTNAYGFL 612
                    |..|:|.||:              ..|.....|| |..::..:|:|:|.|.||||.:
Human   396 IFILPLMHTYAGLAVICA--------------LIGFSSGYFS-LMPVVTEDLVGIEHLANAYGII 445

  Fly   613 MLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAG-----GLILLSAFLCYPLTWVSR 663
            :...|::|..|.|.||.:|.:|..|:.:||..|     |::.|....|..:...||
Human   446 ICANGISALLGPPFAGWIYDITQKYDFSFYICGLLYMIGILFLLIQPCIRIIEQSR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS_MCT_SLC16	49..>225	CDD:340910	67/176 (38%)
		MFS	<477..658	CDD:475125	52/201 (26%)
SLC16A14	NP_689740.2	MFS_MCT14	33..492	CDD:340987	145/626 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..255		12/137 (9%)