DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6701 and Slc25a16

DIOPT Version :9

Sequence 1:	NP_001188923.1	Gene:	CG6701 / 36550	FlyBaseID:	FBgn0033889	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_038954788.1	Gene:	Slc25a16 / 361836	RGDID:	1311311	Length:	991	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	194/972 - (19%)
Similarity:	339/972 - (34%)	Gaps:	340/972 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 IEEYKLDTDVKPTLLKFQKRLLLQSDKDFELQSLGCYICQENFEKIEKYEEHVEYHGDESDFQSL 242
            ::|..|.|..:...||...||.|..|:      :.|.: :|......|:.:...:.|.:::|..:
  Rat   180 LQELALQTLREVRHLKEMYRLNLSQDE------VRCEV-EEYLPSFSKWADEFMHKGTKAEFPQM 237

  Fly   243 -----KKMKKYPTP-----IVSLSYQTCVDSHYFG-------------------------FTLKT 272
                 .......:|     :.||..:..:.|..||                         ..|||
  Rat   238 HLSLPSDSSDRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKTKYKIMPLELKT 302

  Fly   273 --------FRKDLVVDKFIIVQLRQ-------FYYVYGAQMPLPVNGSGELVFFVDSHVFMILRE 322
                    .|..:::...:..:.|:       .|...|...|:|.|       .:|....:.||.
  Rat   303 GKESNSIEHRGQVILYTLLSQERREDPEAGWLLYLKTGQMYPVPAN-------HLDKRELLKLRN 360

  Fly   323 QPIVIGFTI--------QGE-----------------KY-------------VEQHH------FM 343
            |   :.|::        .||                 ||             |||.|      .|
  Rat   361 Q---LAFSLLHRVSRAAAGEEARLLALPQIIEEEKTCKYCSQMGNCALYSRAVEQVHDTSIPEGM 422

  Fly   344 R------TEALPKASFNINPYRL---------SSKETFKSKGLPPANPPIQVLSALKHEDAQMCL 393
            |      |:.|.:|  ::..:.|         .||:|.||      :..|.:..|.|.|::..|:
  Rat   423 RSKIQEGTQHLTRA--HLKYFSLWCLMLTLESQSKDTKKS------HQSIWLTPASKLEESGNCI 479

  Fly   394 ASFDNQYQNYCERGREITQENLTGTLRTLLQVEDIERL--QHYLSLKQSEMELHQFGRELSVKMQ 456
            .|                          |::.|.::|:  .||         ||.|.|:   ...
  Rat   480 GS--------------------------LVRTEPVKRVCDGHY---------LHNFQRK---NGP 506

  Fly   457 MGTTSMSVED--ILSPGDDVLIINEKGNPK----SAVRKMLENNNNVL-ELALKDFDSILRWARN 514
            |..|::...|  |||..:..|....||..|    :||..:|:.|.:.| |..|...|...:.. :
  Rat   507 MPATNLMAGDRIILSGEERKLFALSKGYVKRIDTAAVTCLLDRNLSTLPETTLFRLDREEKHG-D 570

  Fly   515 VDGMVGSLDKQPRVYFARILGVSTQRVNITCERQLPDNTTYTLIFRPLRAVMRYQYRALQQLSFT 579
            ::..:|:|.|                        |.:||..:   :.||.:: ..::..|.:::.
  Rat   571 INTPLGNLSK------------------------LMENTDSS---KRLRELI-IDFKEPQFIAYL 607

  Fly   580 RHSDVQRILFPGEIPNTPLASGVLQLNNKLISTNPEQMQAVRQIALSPRLKAPYIVFGPPGTGKT 644
            ..      :.|.:..:|        :.|.|...|..|.||::::.||   |...::.|.||||||
  Rat   608 SS------VLPHDAKDT--------VANILKGLNKPQRQAMKKVLLS---KDYTLIVGMPGTGKT 655

  Fly   645 STIVEAIYQLYINRPETHILVLAGSNTACDEVALRLLR---AIAKAPQS-QPRPLTRIFSANCDR 705
            :||. |:.:: ::.....:|:.:.:::|.|.:.|:|.:   ...:..|| :..|..:.|:.....
  Rat   656 TTIC-ALVRI-LSACGFSVLLTSYTHSAVDNILLKLAKFKIGFLRLGQSHKVHPDIQKFTEEEMC 718

  Fly   706 RIDNIDDLLLEYSNMYTVHFYPAVQAVHQYRIVICTLSLAGKLSTGGFAANNVYTHVFVDEAAAS 770
            |:.:|.. |.....:|..|  |          |:.|..:.  :|...| :...:....||||:..
  Rat   719 RLRSIAS-LAHLEELYNSH--P----------VVATTCMG--ISHPMF-SRKTFDFCIVDEASQI 767

  Fly   771 TEAEVLMGITCTLSPTLNLILSGDHKQLGPVLQSQRANEWGLGLTLFERLLQRKCYQVEEDGSYN 835
            :: .:.:|   .|..:...:|.||||||.|::.::.|...|:..:||:||            ..|
  Rat   768 SQ-PICLG---PLFFSRRFVLVGDHKQLPPLVLNREARALGMSESLFKRL------------ERN 816

  Fly   836 ASVQTRLIRNFRSHPEIVSLYNNMYYEGHLRTEAPMEIVCRFHNWFYLPNATFPIMFHSVFGTTM 900
            .|...:|...:|.:.:|:||.|.:.|||.|.        |                     |:..
  Rat   817 ESAVVQLTIQYRMNRKIMSLSNKLTYEGKLE--------C---------------------GSDR 852

  Fly   901 NTKSSVSLCNNKEI--DVVMDYVKDLMYFGL----NGEKLLQTDIGIISPYKNQYQRIQEQLNMR 959
            ...:.::|.|.|::  :...||..:....|:    |....|.|| .:.:|
  Rat   853 VANAVITLPNLKDVRLEFYADYSDNPWLAGVFEPDNPVCFLNTD-KVPAP--------------- 901

  Fly   960 NWSQIDCGSVELFQGKEKHVIIVS-FVRSFTPKLGFLNNERRLNVLLSRPISLLILIGNPRT 1020
              .||:.|.|.........|.:.| |:::..|:                     ||..:|||
  Rat   902 --EQIENGGVSNVTEARLIVFLTSTFIKAAAPR---------------------ILASSPRT 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6701	NP_001188923.1	TIGR00376	424..1037	CDD:273041	133/617 (22%)
		AAA_19	618..687	CDD:289986	20/71 (28%)
		AAA_12	812..1019	CDD:289832	39/213 (18%)
Slc25a16	XP_038954788.1	DNA2_N-like	127..366	CDD:411722	35/202 (17%)
		TIGR00376	471..931	CDD:273041	132/624 (21%)
		DEXXQc_DNA2	625..828	CDD:350799	59/239 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930