Protein Alignment shot and Clmn

DIOPT Version :10

• Sequence 1: NP_725339.1
• Gene: shot / 36542
• FlyBaseID: FBgn0013733
• Length: 8805
• Species: Drosophila melanogaster
• Sequence 2: NP_444385.2
• Gene: Clmn / 94040
• MGIID: 2136957
• Length: 1052
• Species: Mus musculus
• Alignment Length: 1041
• Identity: 200/1041 - (19%)
• Similarity: 354/1041 - (34%)
• Gaps: 328/1041 - (31%)

  Fly   160 VRKVT-TLSRAEENAQPAEDLLPPAKMIRSSELEYRRALPPAIESSSTQRREISDIVVGKEDNVS 223
            ::::| .|||:..::.     |.|......|:..|    ||   :.:|:|    .:.|..:|...
Mouse   140 IKELTGNLSRSSPSSS-----LSPGSGGTDSDSSY----PP---TPTTER----SVAVAVKDQRK 188

  Fly   224 AREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAFH 288
            |.:.||.|.:|.|.:| ||.|.||..|||.||||.|::....|.|:|.::|..|..|:.||.||.
Mouse   189 AIKTLLSWVQRKTRKY-GVAVQDFAGSWRSGLAFLAVIKAIDPSLVDMKQALEDSTRDNLEKAFS 252

  Fly   289 IVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFP--EPPS-IHPLFDMESQ-----RRVH 345
            |......:.|||:|||:..:.|||:|::||::...:.||  ||.. ::|  |.|:.     .|:.
Mouse   253 IAHDSLHIPRLLEPEDIMVDMPDEQSIVTYVAQFLERFPELEPEDFVNP--DKEAPIESTFVRIK 315

  Fly   346 EYRDLAQQFIYWCRE--KTAYL--QERSF-PPTLIEMKRLLSDLQRFRSDEVSARKREKSKLIQI 405
            |........:....|  :.||.  ||.|: ||..:.:...|.....|..|...:.|...|....:
Mouse   316 ESPSEQGSRVLLLSENGERAYTVNQETSYPPPDKVFVCDQLESPTGFCLDSAPSHKLSDSSTEFM 380

  Fly   406 YKELERYFE-TVGEVDVEAELRPD----AIEKAWYRMNTALQDREVILQQEIE------------ 453
            ::.:::..: :.|:....||..|:    :..|...|.|:....:.|..:.::.
Mouse   381 HEIIDQVLQGSTGKTGSIAEPTPESSILSTRKDGRRSNSLPVKKTVHFEADLHKDASCSKDPFYS 445

  Fly   454 ---RLERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEAL-----ETEIR 510
               |.|...:...::.::..||..      ..:.:|.::.|:    :|:.::||.     |:.:.
Mouse   446 SDFRFEGSPKATKELSKQDGHVSL------AEVSKEKKKSEQ----EARLVLEAASDKVPESTVD 500

  Fly   511 HLEEPIQDM--NQDCHVLNEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLS--GLK---- 567
            .|:...||.  :||                              ::|....|:..|  |.|
Mouse   501 GLDAVPQDAQPSQD------------------------------SSFCNGTVESPSSQGEKGPPP 535

  Fly   568 -YPVHETTVTRQTRMVVE---SRQIDTNPHF-----------RDLQEHIEWCQNKLKQLLAADYG 617
             .|...|.:...|.:.|:   ...:|...:|           |||.:..     ...|....|..
Mouse   536 SSPGDHTLLANSTELKVQLLTVEPMDKEDYFECIPLKASKFNRDLVDFA-----STSQAFGEDPS 595

  Fly   618 SDLPSVKEELDRQQHEHKIIDQFHTKILNDERQQTKFSGDELALYQQRL---------------- 666
            |...:..||...:.|..|           ..::::|....|....:.||
Mouse   596 SHEKTRGEEEGSENHAEK-----------PGKRKSKSPRAETEAAESRLEPKKLEPPPKDPEQED 649

  Fly   667 -----------NQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQWLNEKE----------QV 710
                       ::..|||.:....||:..|:.:      |:|.:....:.|:|          .:
Mouse   650 QGHALPPETPADKKPKVYEKAKRKSTRHHSEEE------GEAESGFSAVCEEEIPSAPPSTSVSL 708

  Fly   711 EITRDWADKQLD------------LPSVHRYYENLMSELEKREMHFATILDR----GEALLNQQH 759
            |..|..:::.||            :|....||.:.       |:..|.:|:.    ||.|.::
Mouse   709 ETLRSHSEEGLDFKPSPPLSKISVIPHDLFYYPHY-------EVPLAAVLEAYAEGGEDLKSE-- 764

  Fly   760 PASKCIEAHLTALQQQWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAKRDEILNSKFSQS 824
                                       :..|:|..:.:     ::|:.:..|..||
Mouse   765 ---------------------------DTDLEHPEDSY-----LQDSREEEADEDE--------- 788

  Fly   825 DFGLDQGETLLRGMQDLREELNAFGETVATLQRRAQTVVPLNKRRQPVNR---------QGPVQA 880
                                     |...:.|......:|::.....|:.         :||..|
Mouse   789 -------------------------EEAQSSQSSCSFSLPVDNSYPSVSEHVSHVDGSSEGPTSA 828

  Fly   881 ICAYKQQGQLQIEKGETVTLLDNSGRVKWRVRTAKGQEGPIPGACLLLP--PPDQEAIDAAERLK 943
            :...........:..||        :....|.:.:.||.|.|.    ||  |.:::..:|:...|
Mouse   829 LGPGSPPSHEDHQPKET--------KENGPVESQQSQEPPNPE----LPTKPLEEKLTEASTSSK 881

  Fly   944 RLFDRSVALWQKKHLRLRQNMIF---ATIRVVKGWDFDQFLAMGPEQRTAIRRALNDDA------ 999
            :...|       ||:...::.:|   .|:|     ..|.......|.:...|.:.:|.:
Mouse   882 KKEKR-------KHMDHVESSLFIAPGTVR-----SSDDLEENSSEHKVPSRNSHSDSSIYIRRH 934

  Fly  1000 -DKLLSEGDPNDPQLRRLRREMDEVNRLFDEFEKRARAEEESKQASRIFTEECLAIKSKLEDMAR 1063
             ::.|.....:..|||......|..||:.:.:.            |:..||..|.......||.|
Mouse   935 TNRSLELDHFSYVQLRNAADLDDRRNRVLNRYN------------SQKLTELILQFYGIRADMKR 987

  Fly  1064 E 1064
            |
Mouse   988 E 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401	70/229 (31%)
		CH_PLEC-like_rpt2	223..327	CDD:409038	43/103 (42%)
		SPEC	471..689	CDD:238103	44/272 (16%)
		SPEC	690..866	CDD:238103	26/201 (13%)
		SH3_10	864..929	CDD:407754	12/73 (16%)
		SPEC	1047..1250	CDD:238103	7/18 (39%)
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1980	CDD:459901
		DUF5585	2860..>3198	CDD:465521
		SMC_prok_B	<4936..>5564	CDD:274008
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:413338
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:181619
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103
		SPEC	7314..7526	CDD:238103
		SPEC	7528..7747	CDD:238103
		SPEC	7749..7968	CDD:238103
		SPEC	7973..8181	CDD:238103
		FRQ1	<8375..8444	CDD:444056
		GAS2	8450..8522	CDD:128539
		PHA03307	8550..>8795	CDD:223039
Clmn	NP_444385.2	Actin-binding	1..288		57/164 (35%)
		CH_CLMN_rpt1	29..142	CDD:409040	0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..178		10/45 (22%)
		CH_CLMN_rpt2	186..291	CDD:409094	43/105 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..420		7/28 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..545		20/129 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..727		25/158 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	758..929		38/262 (15%)