Protein Alignment shot and Drp2

DIOPT Version :10

• Sequence 1: NP_725339.1
• Gene: shot / 36542
• FlyBaseID: FBgn0013733
• Length: 8805
• Species: Drosophila melanogaster
• Sequence 2: NP_076461.2
• Gene: Drp2 / 66027
• RGDID: 621750
• Length: 957
• Species: Rattus norvegicus
• Alignment Length: 1057
• Identity: 197/1057 - (18%)
• Similarity: 377/1057 - (35%)
• Gaps: 302/1057 - (28%)

  Fly  7372 HGSNLMNMCGEPDKPEVKKHIEDLDNAWD---------------------------NITALYAKR 7409
            |.|:|.|.|   .:|:|:..:......||                           |:.....|:
  Rat    27 HSSSLRNTC---PQPQVRAAVTIPAPPWDGAGDPCLSPKLLNGSVGAVGPLEPSAMNLCWNEIKK 88

  Fly  7410 EENLIDAMEKAMEFHE-----TLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQLKSFKDEV- 7468
            :.:.:.|..:|...|.     .||.::.:|::.:::.:....:..|:..|:::.|...:|.:||
  Rat    89 KSHNLRARLEAFSDHSGKLQLPLQEIIDWLSQKDEELSAQLPLQGDVALVQQEKETHAAFMEEVK 153

  Fly  7469 --DPHMVEV-------------EALNRQAVELTERTSPEQ-----AASIREPLSVVNRRWEALLR 7513
              .|::..|             |.|.....| ::.|||.|     :..:.:..:|.:..||.|..
  Rat   154 SKGPYIYSVLESAQAFLSQHPFEELEESHSE-SKDTSPRQRIQNLSRFVWKQATVASELWEKLTA 217

  Fly  7514 GMVERQKQLEHALLHLGQFQHALNELLVWINKTDSTLDQLKPIPGDPQL--LEVELAKLKVLAND 7576
            ..|::.:.:||.|.||.:.|.|:.||...:.:.:......:|| ||..:  |...:..:|:...:
  Rat   218 RCVDQHRHIEHTLEHLLEIQGAMEELSSTLTQAEGVRATWEPI-GDLFIDSLPEHIQAIKLFKEE 281

  Fly  7577 IQAHQNSVDTLNDAGRQL-IETEKGSVEASTTQEKLRKLNNEWKQLLQKASDRQHELEEALRE-- 7638
            ....::.|..:||...|| |.....|:|.|   ..|.::|..||||....::|..:|::|.|:
  Rat   282 FSPVKDGVKLVNDLAHQLAISDVHLSMENS---RALEQINVRWKQLQVSVAERLKQLQDAHRDFG 343

  Fly  7639 ---AHGYIAEVQDILGWLGDVDAVIGASKPVGGLPETATEQLE-------RFMEVYNELDENRPK 7693
               .|.....||  :.|    :..|..:|    :|.....|.:       :..|:|..|.:
  Rat   344 PGSQHFLSTSVQ--VPW----ERAISPNK----VPYYINHQAQTTCWDHPKMTELYQTLAD---- 394

  Fly  7694 VETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRASDKKIKLE-IALKEATEFHDTL 7757
                          .|.:|.|:......||.::            |.::|: :.|..|      |
  Rat   395 --------------LNNIKFSAYRTAMKLRRVQ------------KALRLDLVTLTTA------L 427

  Fly  7758 QAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHREAMLLLDKKGTHLKYFSQKQ 7822
            :.|.|...||.:.:.:...|...|..:..::||.:.:..:|.      |.:|
  Rat   428 EIFNEHDLQASEHVMDVVEVIHCLTALYERLEEERGILVNVP------LCVD------------- 473

  Fly  7823 DVILIKNLLVSVQHRWERVVSKAAERTRALDHGYKEAREFNDAWSGMMQYLQ-----------ET 7876
               :..|.|::|                           |:...||.|:.|.           |.
  Rat   474 ---MSLNWLLNV---------------------------FDSGRSGKMRALSFKTGIACLCGTEV 508

  Fly  7877 EQVLDQIIEEATASKEPQKIKKYIGKLK----ETHRQLGAKQSVYDGT-----------MRTGKN 7926
            ::.|..:..: .|:...|..::::|.|.    :..|||| :.:.:.|:           ..|||.
  Rat   509 KEKLQYLFSQ-VANSGSQCDQRHLGALLHEAIQVPRQLG-EVAAFGGSNVEPSVRSCFRFSTGKP 571

  Fly  7927 LLERAPKGDRPVLDKMLIELKEQ-WTRVWSK-------------SIDRQ--------RKLE---- 7965
            ::|.:     ..|:.:.:|.:.. |..|..:             ||.||        |.|:
  Rat   572 VIEAS-----QFLEWVNLEPQSMVWLAVLHRVTVAEQVKHQTKCSICRQCPIKGFRYRSLKQFNV 631

  Fly  7966 ---EALLLSGQFSDALGE-----LLDWLKKAKSRLNENGPVHGDLETVQGLCEHHKHIEQDLQKR 8022
               :...|:|:.|.  |.     ::::.....|  :||  :.....|::......::..:..|:.
  Rat   632 DICQTCFLTGKASK--GNKLHYPIMEYYTPTTS--SEN--MRDFATTLKNKFRSKQYFSKHPQRG 690

  Fly  8023 AAQMQGVLKTGRDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKRGERLQVALVDAEKLNARVQAL 8087
            ...:|.||::... |...::|.:..             :....|.|.....|.:.|..|.   :.
  Rat   691 YLPVQSVLESDCS-ETPASSPMLPH-------------ADTHSRIEHFASRLAEMESQNC---SF 738

  Fly  8088 F-------DWLDHAEHKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINK 8145
            |       |.:|..::.||::....|.|....:.....|            .||:....|.|: .
  Rat   739 FNDSLSPDDSIDEDQYLLRHSSPITDREPAFGQQAPCSM------------ATESKGELEKIL-A 790

  Fly  8146 AYPDAIPIIKNWLSIIQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNL 8210
            ...|...|::..|..::.:.||    |:...:..|...::..|..:  |||||     |..:|..
  Rat   791 HLEDENRILQGELRRLKWQHEE----AVEAPTLAEGSAEATPDHRN--EELLA-----EARILRQ 844

  Fly  8211 KHEQLPDEIPPVEKLIEDHKEFMENTARRQNEVDRACKPRQLPPGARKPSRSGKTPVFKGSRDQG 8275
            ...:|...:    :::|||.:.:|:..:|..|:     ..|.|..:.....:|.:......:.:|
  Rat   845 HKSRLETRM----QILEDHNKQLESQLQRLREL-----LLQPPTESDGNGSAGSSLASSPRQSEG 900

  Fly  8276 LNARKGSRITPTRDTPD 8292
            .:.|:..:.||..:..|
  Rat   901 SHPREKGQTTPDTEAAD 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shot	NP_725339.1	SAC6	204..>420	CDD:227401
		CH_PLEC-like_rpt2	223..327	CDD:409038
		SPEC	471..689	CDD:238103
		SPEC	690..866	CDD:238103
		SH3_10	864..929	CDD:407754
		SPEC	1047..1250	CDD:238103
		SPEC	1153..1390	CDD:238103
		PLEC	<1498..1526	CDD:197605
		Plectin	1949..1980	CDD:459901
		DUF5585	2860..>3198	CDD:465521
		SMC_prok_B	<4936..>5564	CDD:274008
		SPEC	5304..5513	CDD:238103
		SPEC	<5658..5787	CDD:413338
		SPEC	5793..6007	CDD:238103
		SPEC	6011..6220	CDD:238103
		SPEC	6118..6330	CDD:238103
		PRK09039	<6279..6441	CDD:181619
		SPEC	6443..6660	CDD:238103
		SPEC	6663..6878	CDD:238103
		SPEC	6880..7087	CDD:238103
		SPEC	6986..7196	CDD:238103
		SPEC	7196..7417	CDD:238103	11/71 (15%)
		SPEC	7314..7526	CDD:238103	39/206 (19%)
		SPEC	7528..7747	CDD:238103	49/234 (21%)
		SPEC	7749..7968	CDD:238103	46/273 (17%)
		SPEC	7973..8181	CDD:238103	35/219 (16%)
		FRQ1	<8375..8444	CDD:444056
		GAS2	8450..8522	CDD:128539
		PHA03307	8550..>8795	CDD:223039
Drp2	NP_076461.2	Spectrin 1	102..179		13/76 (17%)
		SPEC	111..339	CDD:238103	55/232 (24%)
		Spectrin 2	231..337		29/109 (27%)
		WW	357..385	CDD:238122	5/35 (14%)
		EFh_DRP-2	422..583	CDD:320006	38/222 (17%)
		EF-hand-like motif	422..460	CDD:320006	9/43 (21%)
		EF-hand-like motif	468..502	CDD:320006	11/82 (13%)
		EF-hand-like motif	508..544	CDD:320006	5/36 (14%)
		EF-hand-like motif	557..583	CDD:320006	5/30 (17%)
		ZZ_dystrophin	608..656	CDD:239074	10/49 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	877..923		7/41 (17%)