DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment shot and SYNE2

DIOPT Version :10

Sequence 1:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster
Sequence 2:XP_011534876.1 Gene:SYNE2 / 23224 HGNCID:17084 Length:6936 Species:Homo sapiens


Alignment Length:8886 Identity:1622/8886 - (18%)
Similarity:2997/8886 - (33%) Gaps:2924/8886 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 HIVRKVTTLSRAEENAQPAEDLLPPAKMIRSSELEYRRALPPAIESSSTQRREISDIVVGKEDNV 222
            ||.:...||| ...| ||:   |....::.||.    .:.|||.:.|..|.|.          .:
Human   136 HIEKLAQTLS-CNYN-QPS---LDDVSVVDSSP----ASSPPAKKCSKVQARW----------QM 181

  Fly   223 SAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAF 287
            |||:|||.||:...|.|..|.|.||.||||:|:||.|::|..||||:|.:..::...::.|..||
Human   182 SARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246

  Fly   288 HIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFPEPPSIHPLFDMESQRRVHEYRDLAQ 352
            .|.|:|..:.|||:|||||..:|||||::||::.......:.|..    ..|:|.:|.:    |.
Human   247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGT----GEEAQGKVKD----AM 303

  Fly   353 QFIYWCREKTAYLQERSFPPTLI-EMKRLLSDLQRFRSDEVSARKREKSKLIQIYKELERYFETV 416
            .::...:||...|.:.|...|.. :...|||.::.|..:     |:....::.|.::|:      
Human   304 GWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEE-----KKSFLDVLSIKRDLD------ 357

  Fly   417 GEVDVE-AELRP--DAIE---KAW-----YRMNTALQDREVILQQEIERL--ERLQRLADKVQRE 468
             |:|.: .:||.  |.::   .||     |.:...|...|..| ||:|.|  |.|....|..| .
Human   358 -ELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL-QEVEELMDEDLSASQDHSQ-A 419

  Fly   469 IKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLEEPIQDMNQDCHVLNEGRYPH 533
            :..:.:|:|..                   ||:::..|   .|....:...|:|     |...|.
Human   420 VTLIQEKMTLF-------------------KSLMDRFE---HHSNILLTFENKD-----ENHLPL 457

  Fly   534 V-----SELHKKVNKLHQRWAQLRTNFH------TNLVQKLS------GLKYPVHETTVTRQTRM 581
            |     .|:.:::|.:.::...|...||      ..||.::.      .:||...|:.       
Human   458 VPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV------- 515

  Fly   582 VVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFHTKILN 646
                                        :||..|:                 ||.|::  .:.| 
Human   516 ----------------------------ELLLEDW-----------------HKFIEE--KEFL- 532

  Fly   647 DERQQTKFS--GDELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQWLNEKEQ 709
             .|..|.|.  |:   :|:....:.|.:..:.:...    ||:...:..:....:.||       
Human   533 -ARLDTSFQKCGE---IYKNLAGECQNINKQYMMVK----SDVCMYRKNIYNVKSTLQ------- 582

  Fly   710 VEITRDWADKQLDLPSVHRYYENLMSELEKREMHFATILDRGEALLNQQHPASKCIEAHLTALQQ 774
             ::...||....:|..:...:|....| |.:|:.|.|:                          .
Human   583 -KVLACWATYVENLRLLRACFEETKKE-EIKEVPFETL--------------------------A 619

  Fly   775 QWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAK-RDEILNSKFSQSDFGLDQGETLLRGM 838
            ||            :|:|||        :.:|..:|.: .::::.|..|                
Human   620 QW------------NLEHAT--------LNEAGNFLVEVSNDVVGSSIS---------------- 648

  Fly   839 QDLREELNAFGETVATLQRRAQTVVPLNKRRQPVNRQGPVQAICAYKQQGQLQIEKGETVTLLDN 903
            ::||.....:.:.|:..|......:.:.|:.||.                            .||
Human   649 KELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPT----------------------------FDN 685

  Fly   904 SGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKHLRLRQNMIF-A 967
            ||.:     .:|.::..:           :.:.|.:..|...:::::...:|..   ::|..| .
Human   686 SGNI-----LSKEEKATV-----------EFSTDMSVELPENYNQNIKAGEKHE---KENEEFTG 731

  Fly   968 TIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQLRRLRREMDEVNRLFDEFEK 1032
            .::|.|                        |.:||:.:.:..:.:.:.: .:.|:|:...:|..|
Human   732 QLKVAK------------------------DVEKLIGQVEIWEAEAKSV-LDQDDVDTSMEESLK 771

  Fly  1033 RARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPLPRDLDSLEHVLEIHSDYERRLHLL 1097
            ...|:      ..:|.|    :.::.|||           |..|:.::       |..|...|:|
Human   772 HLIAK------GSMFDE----LMARSEDM-----------LQMDIQNI-------SSQESFQHVL 808

  Fly  1098 EPELK-HLQETFRTIALKTPVLKKSLDNLMELWKELNTQSGLHKDRLKLLEASLAGLEDNEHVIS 1161
            ...|: .:||....:.:....|..:|.||.::..:|:.       |||:.|:.           .
Human   809 TTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDI-------RLKMEESQ-----------K 855

  Fly  1162 ELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLK- 1225
            |||:.:.|.|.|....|...::..:  |.:.:|......:.|...|.::|     ...|..|:| 
Human   856 ELESYMMRAQQLLGQRESPGELISK--HKEALIISNTKSLAKYLKAVEEL-----KNNVTEDIKM 913

  Fly  1226 RLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAMPTATSAY 1290
            .|......:..:|.::.::|                   |:.|::..:|....:||         
Human   914 SLEEKSRDVCAKWESLHHEL-------------------SLYVQQLKIDIEKGKLS--------- 950

  Fly  1291 ELDKLLGAAIERKPKIENVNVAGGR---LIR--EAKIYDSKCL-------RFVDWLVEARPSFSP 1343
              |.:|  .:|::...|...:..||   ||:  ||...:..||       ..:..|.|..|| ..
Human   951 --DNIL--KLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS-QK 1010

  Fly  1344 PRRDLRPADSDPGATQYYSQRLDNLNTKNDRLLEQLSQRLKTAIEVNGSDGLQYAESLQKPLKTF 1408
            .:::::....|      |.|:::.|              ||.|.|::        .:||      
Human  1011 SQQEVKRLLKD------YEQKIERL--------------LKCASEIH--------MTLQ------ 1041

  Fly  1409 RVDFSAGSVPTGDGYAARQEDLYTTTYSTTQISSTKTTKSSTKSVYSSDGLDAASQEVSTAGLPQ 1473
                     ||..|              |::...|.||..                  :..|.|.
Human  1042 ---------PTAGG--------------TSKNEGTITTSE------------------NRGGDPH 1065

  Fly  1474 SQIQFNEIRTLKRSQQLGGHSVLDIAGIRDPRTGRVLTIGEAIQLRILDVRTGEMLVGDRRITLE 1538
            |:..|.:                                                  .|.:.:.|
Human  1066 SEAPFAK--------------------------------------------------SDNQPSTE 1080

  Fly  1539 QAADQGLIDLQLAKQLLEPGAGRDASGRELSLLEVIQ--REISEAESGYETAEKRIKVNNTVTVE 1601
            :|              :||       ..:.||..|::  :|.|..|..|..:     :|      
Human  1081 KA--------------MEP-------TMKFSLASVLRPLQEESIMEKDYSAS-----IN------ 1113

  Fly  1602 QTSGELGSPENPRNIADAITAGSVDTKTGLYRVKSGQTISLAEAYERGYLIRHESVTIKSNALCL 1666
                                                   ||.|.|:                 ..
Human  1114 ---------------------------------------SLLERYD-----------------TY 1122

  Fly  1667 SDAIAHGLVDGAGWIADRNSGDKFRLDSAIANQLIDASVREVVDAKRDTKITLQEALQSGVLNAK 1731
            .|.:.|.|.:....|....|.::.|..|.:..:|.|..|     .|.:|....:|   ..:::.|
Human  1123 RDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQV-----IKNETDARWKE---FEIISLK 1179

  Fly  1732 TGRYVNEVTKEKLTFAEARNRQLIVKPYTLKDICDLNLLDKQAQITSPMRREKLSIMQAIEAGVL 1796
            ...:||:                |.||:.:|:...|...:::.|:|...|.|.|.....:...|.
Human  1180 LENHVND----------------IKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVE 1228

  Fly  1797 DGNLLKCITKRKGELVTLQEAIADGI-VLPAECKYRDFMT-----GELISIPEAVERGLISSVAQ 1855
            ..:||.|     |..:.|.:....|. ::.|:..|:....     .:.|.|...:|......:.:
Human  1229 KASLLLC-----GSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288

  Fly  1856 RSIFDIDGFKDL-----RSNDYVSFNVALSRDLLRRKSTGFA-LETGRDSLVPL-EVAVSEGLVR 1913
            ...||:...:::     ...:.::..|..|.|.|:......| |.|.:.|..|: :::.|:..|.
Human  1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVA 1353

  Fly  1914 QEVYEMFSRGIGVQNASGKELSVFDLVYH-----NLIDPKTGYLLDPKTGETVPLDTAIERKFIT 1973
            ||      ..:.|:|..|:...:.|...|     .::|..   ..|.:.|:    ||:.|.    
Human  1354 QE------NTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMS---FKDAERGD----DTSCEN---- 1401

  Fly  1974 PEGALLLSSLLNITLTTETVTRTINRYVTIRAGSQEPVDSVLLTFTE--AVRQGFIDEERQLFKD 2036
                  |....:|.|:.           |...|.||       .|||  .:.:..|.:..:|.| 
Human  1402 ------LLDAFSIKLSE-----------THGYGVQE-------EFTEENKLLEACIFKNNELLK- 1441

  Fly  2037 PKTGNIYSVQ-QALNYGLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVE 2100
                ||..|| |....||..|    |||...:|||:                             
Human  1442 ----NIQDVQSQISKIGLKDP----TVPAVKHRKKS----------------------------- 1469

  Fly  2101 KSVEIPISQELVKPHRVVSEFINLEKSSYIEQNVTERQIMELPPGGWRLKDAIEQRLFNPDTGVF 2165
                      |::..:|:.|        |.|:   :|.:.|:.......||              
Human  1470 ----------LIRLDKVLDE--------YEEE---KRHLQEMANSLPHFKD-------------- 1499

  Fly  2166 HVQGTDRLVNFEECINKQIINNLSLSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGMRS 2230
               |.::.|| ::|.|        ..|:..||       .|...:.|:..|......||.|..:|
Human  1500 ---GREKTVN-QQCQN--------TVVLWENT-------KALVTECLEQCGRVLELLKQYQNFKS 1545

  Fly  2231 AI------DESKIILETVPATRGANQKTILRITKV-NNIPDVLEVSTPLKDAPPKFVEVLTCQRE 2288
            .:      :||.|.|:.....:...:|.|..|..| ....:.|||...:..........|...:.
Human  1546 ILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKT 1610

  Fly  2289 LASPEPLQIAPGAIYDP---------------STALVIFTQTGETENIFD----AARQGLVDEQL 2334
            ...| |.:.....|.|.               ..||.::.:....:|:.|    .|.|.:...||
Human  1611 FEEP-PFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL 1674

  Fly  2335 IKIVDPTTKQPISVTEAIARSIYDPKTATILDSEGQPVDLITATKLGLLSVVGAPLVAAEGALRT 2399
            .:......|:.:.|        ::.||:..                             ...:..
Human  1675 TEEDRERLKEELQV--------HEQKTSEF-----------------------------SRRVAE 1702

  Fly  2400 VRFVTDPRTGEQIPVEVAYERGIVSRDQLHRGRSFDSEPATVEDKVVVLQRMRKVILKPKDALRK 2464
            ::|:..   ..:||:|                                ||.|...||...:.::|
Human  1703 IQFLLQ---SSEIPLE--------------------------------LQVMESSILNKMEHVQK 1732

  Fly  2465 GIIDEETCEILENTS-----NFTNPKGEVVNITEALNTGLIDGRRGQVIDPQNN-RVLNLRQAVE 2523
            .:..|..|..|..::     :....|.: :.:||:|.         :.:.|.:: .:....:.::
Human  1733 CLTGESNCHALSGSTAELREDLDQAKTQ-IGMTESLL---------KALSPSDSLEIFTKLEEIQ 1787

  Fly  2524 QKIIDSEQTNHILMPLAKSLSVPRLADQGLIDPQTQTIVHPESGYPLSIHEAIVCEVLDPHSKLH 2588
            |:|:   |..|.::.|...:        |.:.|:...:...        :|::        |.|.
Human  1788 QQIL---QQKHSMILLENQI--------GCLTPELSELKKQ--------YESV--------SDLF 1825

  Fly  2589 KPEKCTLEEAITKGIINADDSTFN--YKNKTLNITEAIEAKLFDPSYDQQKSKVEIPPVGMIFPV 2651
            ..:|..|::..:| ::|.....||  :.|..:|:.|..|:.....|.:|:..|     :.....:
Human  1826 NTKKSVLQDHFSK-LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK-----LSDFLTL 1884

  Fly  2652 AVEKSLVEPSKRVVLHPSTKKALPIKQAIEENFIMSIPYSPKPDAIE-VVTAMEQDLIDVAAQTL 2715
            ....|.::....|:.|  .||.|| |..::|.....:....:.:.:| :..|..::|.|...|.|
Human  1885 EGRNSKIKQVDSVLKH--VKKHLP-KAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLL 1946

  Fly  2716 T---------------------VPSTGERIPL--------RQAMENGVLVVKNLSDFVITQ---- 2747
            .                     :...||:..|        |:..|:...:..:|.::..|:    
Human  1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011

  Fly  2748 -------------------------KPIPKTEIMETVRAVHTVTTKTIELMQGYVLISNNEVQNV 2787
                                     |.:| ||........|.|.....|:.:..::::::|    
Human  2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLP-TEDQSFNDLAHDVIHWIKEIKESLMVLNSSE---- 2071

  Fly  2788 NTGEVCSLEE----AKELGILREESTTR-ET---KAAAGESP---ESVGDVGTSGDQTVIVEERT 2841
              |:: .|||    .||:.:|:.|...| ||   :|.:.|:|   :::.|:....|.|:.:..  
Human  2072 --GKM-PLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS-- 2131

  Fly  2842 QTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQN---------------VK 2891
               ...|...|..::.....||.:|.   .:..||.|..:|....||:               :|
Human  2132 ---TYLSHQEKLLLEGEKYLQSKEDL---RLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLK 2190

  Fly  2892 DAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTED-AKSTEKPKEPQTSFIEQERRKELQPQ 2955
            .|..|                    .||:|.:||.... .:.|:.|...:..::|.:...|...|
Human  2191 KAQDL--------------------TSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQ 2235

  Fly  2956 QVPSEVDNL---LSETENF------ISSTTANFIANEKQ----QDKP-DTLPQESNLP--LEVES 3004
            |:...|.||   :.|.:::      :::|..||   .|:    .||| |.:..|..|.  .|:|:
Human  2236 QLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNF---SKEFVSFSDKPVDQIAVEEKLQKLQELEN 2297

  Fly  3005 TSTLTTTTVTTI-----TTSSTTTETGNLEPVVVEDVSTTVKEDKVVVKPSTVPEDKTEVSKITE 3064
            ..:|...|:..|     :....|:..|  :.::.:|:.:...:.|.:  .:.:...|.|:.....
Human  2298 RLSLQDGTLKKILALAKSVKQNTSSVG--QKIIKDDIKSLQCKQKDL--ENRLASAKQEMECCLN 2358

  Fly  3065 TITTVTSNETDTVPEKISQKSASEESAKKDPVVTKDTSSRPAETETSPKPVQKEPTPDPAQNTEF 3129
            :|              :..|.::|:..|         .:.|..        :|:.|.|..::|:.
Human  2359 SI--------------LKSKRSTEKKGK---------FTLPGR--------EKQATSDVQESTQE 2392

  Fly  3130 PESIKKDPTPEPDY---KETATEAAQITPKEASPAPTNKNEQSA----EPTSKPEPMPRTAKKEE 3187
            ..:::|   .|.|:   |::|.|.|.......:...:.||.:..    |..::|..:....:.|:
Human  2393 SAAVEK---LEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQ 2454

  Fly  3188 ISEIEPPFT------APLAPFVDQLAETKITEIKTEFKEPVTSSQTITTITTTVKTVDEHPIVEE 3246
            :.|||..:|      |.:.|    |.:|:... |||     |.:..:..|..:.:.:|.  :::.
Human  2455 LEEIEKLYTQLEAKKAAIKP----LEQTECLN-KTE-----TGALVLHNIGYSAQHLDN--LLQA 2507

  Fly  3247 VDEVSKSEK-----IVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEERV------VTVEEP 3300
            :..:.|:::     :.|.:|.....:..:|...|..:|.:..|.:.:.:.:::      :..|:.
Human  2508 LITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKD 2572

  Fly  3301 TITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEI----EQTTNDDQKK 3361
            ::....:....::...|...::.|                    .::.|::    ||.....|||
Human  2573 SLGNLKIKWENLSNHVTDMDKKLL--------------------ESQIKQLEHGWEQVEQQIQKK 2617

  Fly  3362 -PEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQPHSTSD 3425
             .:::|:.::.||....|           :.|.::|..:               :|.:|....|.
Human  2618 YSQQVVEYDEFTTLMNKV-----------QDTEISLQQQ---------------QQHLQLRLKSP 2656

  Fly  3426 K----HQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVDALTTEK--- 3483
            :    :||::.....   .|..:.|.::|   |..|:|....|.|..  ..|.|.|.:...|   
Human  2657 EERAGNQSMIALTTD---LQATKHGFSVL---KGQAELQMKRIWGEK--EKKNLEDGINNLKKQW 2713

  Fly  3484 -TLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEGTPDDEALDVVKLPAE 3547
             ||:|.|.          |...:|   ....:..|:..|.........|..|     .:..||.:
Human  2714 ETLEPLHL----------EAENQI---KKCDIRNKMKETILWAKNLLGELNP-----SIPLLPDD 2760

  Fly  3548 LVESSVKREVPRTLAIGDAISQKLISPDECQVIVDG-EQQSQTVSTLLKEEQLSPLDEVQIIDDK 3611
            :: |.:::                     |:|..|| ..:.|:|.:|.:|           :.||
Human  2761 IL-SQIRK---------------------CKVTHDGILARQQSVESLAEE-----------VKDK 2792

  Fly  3612 LIVLQQVSYLVDADTELTPQNLYELN--IYDPENQY--FIDPST----------GQKISFHTLV- 3661
            :             ..||.....:||  :.|..|||  .:..||          .::.:|..:: 
Human  2793 V-------------PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIR 2844

  Fly  3662 -FDMNVFNPETILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRAN 3725
             |.:.|...||:::....       |||.|..|...|                            
Human  2845 KFQLMVQESETLIIPRVE-------TAATEAELKHHH---------------------------- 2874

  Fly  3726 PEEQKPSGIENVTIDTQTGQV-VLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIEL 3789
                       ||::....:: .:|.|....:.|..|.    .:.::|.:         |:.:|.
Human  2875 -----------VTLEASQKELQEIDSGISTHLQELTNI----YEELNVFE---------RLFLED 2915

  Fly  3790 GVVDMQAGTVIDIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQV 3854
            .:.:::..|....:.::....|:..::.|......|..:|:...             ||..:|::
Human  2916 QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEA-------------DSIQRNEL 2967

  Fly  3855 DVQKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLVPFD-VGVQQCL 3918
            .:.:.:..| |..:|..:.|.:|    .:.|.|...|.|...             || :|     
Human  2968 LLNQEVNKG-VKEEIYNLKDRLT----AIKCCILQVLKLKKV-------------FDYIG----- 3009

  Fly  3919 LKTDNVTWSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGK 3983
                 :.|...:|.|.:          ..|..:|..|::.|:    :|:|...:...:..:|...
Human  3010 -----LNWDFSQLDQLQ----------TQVFEKEKELEEKIK----QLDTFEEEHGKYQALLSKM 3055

  Fly  3984 EAAKVGLLDTVRGTLSSPNISLDEAFVKGYLISTK--KPLSLVDCLLRGLYDPSTAKFTIDDKQL 4046
            .|..:.:.......|.:|:.|.:...:...::|.:  |...|.|.:::.|.:..|...:..:|: 
Human  3056 RAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE- 3119

  Fly  4047 DLKAAIAQKLINPEELVLLDPKTESIISITEAIAKGYLDPIEGYVINPYASTKLSLHEALENRIL 4111
                 |.|..:|.||                                     ...|::.|:|.:|
Human  3120 -----ILQIKLNAEE-------------------------------------NDKLYKVLQNMVL 3142

  Fly  4112 -IPPKRKRSLPDAVYRGLYDPKTGQFSNTVTREKLTTE----RAIRRGILDPDSTVVNVGSGQII 4171
             :.||.            .|.|..|       :||.|.    ..|:..:..|  .::|       
Human  3143 ELSPKE------------LDEKNCQ-------DKLETSLHVLNQIKSQLQQP--LLIN------- 3179

  Fly  4172 PFGVATETGIVDSKHGTVRDADDHPIDFKEAFDRGILVEAKKPLRLIEAVVKNVYDEVDGHFVDP 4236
                      ::.||  :::..|:    .|||...:..|... ::.:.|:.|.            
Human  3180 ----------LEIKH--IQNEKDN----CEAFQEQVWAEMCS-IKAVTAIEKQ------------ 3215

  Fly  4237 KSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDTGIIDAQNSKL--LYNNQTMTLK 4299
               .:.|.:||      .:...::|:|: .|..|||.:       ||.:.:.|  .|.|.| ..|
Human  3216 ---REENSSEA------SDVETKLREFE-DLQMQLNTS-------IDLRTNVLNDAYENLT-RYK 3262

  Fly  4300 HAFDIGILMDVNAPISIQRAIHQGLFDDKTGKLSDPRTGRQITLLESM----RSFVVNPHLPCYF 4360
            .|              :.||:                  ..||.||::    |..|.||      
Human  3263 EA--------------VTRAV------------------ESITSLEAIIIPYRVDVGNP------ 3289

  Fly  4361 DEQTEQMYTLSETCRNGIINRREGVFREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMGFY 4425
            :|..|......|...:.:.:.::             |.|  .||:|...|               
Human  3290 EESLEMPLRKQEELESTVAHIQD-------------LTE--KLGMISSPE--------------- 3324

  Fly  4426 ETSTRKVLHPVTNRKLNLNEACVEDVVSLSSSL-----VKHHETGKYLRLANAIKEQLVDDSRGC 4485
                         .||.| :..::::||.:|::     .:..|..:||            ::..|
Human  3325 -------------AKLQL-QYTLQELVSKNSAMKEAFKAQETEAERYL------------ENYKC 3363

  Fly  4486 YNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFID 4550
            |....|  |:....::...|..:.:.||.|..|:.|.|.|..|                      
Human  3364 YRKMEE--DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK---------------------- 3404

  Fly  4551 PATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRND 4615
               .:..|.::.||                              ::...|.||..:....|: ||
Human  3405 ---ALVSNLISTKE------------------------------ELMKLRQILRLLRLRCTE-ND 3435

  Fly  4616 VVRRQDSVELLNQTPVSVV-ISKPREMSLEEAIRYNIIDPKTALVRDFDSFKFLPYSVAVERGLV 4679
            .:.....|..|.:..:|:: .:|..||..||..:               .:||:...:..|..::
Human  3436 GICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQ---------------EWKFVSEEIEREAIIL 3485

  Fly  4680 DTTKRTLVDPKALYFAFDPTLIVYVREPVTFDQAAE-SKCL-------DLQTGLLTYVPASVPGS 4736
            |..:..|.:            |...:|..|.::.:| ..||       :.|..|||.:...:   
Human  3486 DNLQEELPE------------ISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRI--- 3535

  Fly  4737 ATAAPASDDSANDSLTVIETPKVYTLKEAASAGVVDPDSALVKDLAKAKLVRLPEAFRKGLMDAN 4801
                 .|..:..:|...:||...:                       .::..:.|...|.|....
Human  3536 -----RSIQNVPESSGAVETVPAF-----------------------QEITSMKERCNKLLQKVQ 3572

  Fly  4802 KANVLNTQTSKLCTLQEAYESGLICTPKRSFGLLEAITF-NLYNPTNGCLVD-PFQMHPDIIRRR 4864
            |...| .||.    :||          :.|| ..|.|.. |.:..|.....: .||.||:  :..
Human  3573 KNKEL-VQTE----IQE----------RHSF-TKEIIALKNFFQQTTTSFQNMAFQDHPE--KSE 3619

  Fly  4865 KFTLAEAIGSGLVDPSSTVVRDPSTGVIVPLTAAISSGLIDATEGRLTDANEPKNNIDLVKAAEK 4929
            :|...::|                                 ..:|:||..|..:..  .:|.:|.
Human  3620 QFEELQSI---------------------------------LKKGKLTFENIMEKL--RIKYSEM 3649

  Fly  4930 GLLLPAEQRQAVFEKFNMCEENVNDLLKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIE 4994
            ..::|||....|.|    |.:.:.|:.:.::....|.|.....|.||:|:.|.::       .:|
Human  3650 YTIVPAEIESQVEE----CRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLH-------NVE 3703

  Fly  4995 SQQRPVATCLEQIRQIVLTGGDVLSAPEVTTLENSGRELRSRVDRVNDRT--------------- 5044
            ...:..:..:|:.::|.....|     |:....:...||.|.|..:.::.               
Human  3704 KMLQQKSKNIEKAQEIQKKMWD-----ELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF 3763

  Fly  5045 ---VRLLRRLEAGRDELTKLRSELDVFSDWLQVARRTLEDKERSLSDLTRLPSQADSVREFVSDV 5106
               .::.:|.|....:|.|...:::.:||.|:.....:|:....|::    |:..||:|     .
Human  3764 QQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLAN----PADYDSLR-----T 3819

  Fly  5107 IGHQADLRFITMAAQKFVDESKEFLAILNDFRTSLPERLPHVEPLSSAESPIRQEVSLVSAQYKD 5171
            :.|.|.      ..|..:::|::...:|:.....|       |.||     |..|...::...::
Human  3820 LSHHAS------TVQMALEDSEQKHNLLHSIFMDL-------EDLS-----IIFETDELTQSIQE 3866

  Fly  5172 LLNRVNALQDRV-SGLGGRQREYQDALDKANEWLRSVHPRVSRI--------------------- 5214
            |.|:|.|||.:: ..|...||...|.:...:| ::|:..|||:|                     
Human  3867 LSNQVTALQQKIMESLPQIQRMADDVVAIESE-VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHG 3930

  Fly  5215 --ISEPIAGDPKGVQDQMNEAKALH---------------NELLSSGRLVDNAQQALDNLLRSLG 5262
              |.|.|....|.:.:.::....|.               |:||...:|::|..|..:.||:.:.
Human  3931 EVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVI 3995

  Fly  5263 GQLSPMEINQLELPIADLKNNYQQLLDNLG-----EHCK--TLDKTLVQSQGVQDALDSLVGWVN 5320
            .|     .|:.:..|.:||    |:|:|..     ||..  ..|| |.|.||..:.::..:..:|
Human  3996 KQ-----TNEWDEEIENLK----QILNNYSAQFSLEHMSPDQADK-LPQLQGEIERMEKQILSLN 4050

  Fly  5321 QAEDKFKMNLRPASL-IKERL-QEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKK 5383
            |.::...::|:...| :.:.| |||....:..|..:.|.:..:.....|.:.|....|.:.:| .
Human  4051 QRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLA-A 4114

  Fly  5384 VESNLNDVTVKFEKLYEKA-----------------------NKRGEFLDDVYNRLSRYLDEIST 5425
            ||..:.:.:||.:...|||                       :..|..:.:.|.:       |||
Human  4115 VEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGK-------IST 4172

  Fly  5426 VEQRMASLQEALDSRETSLLSTE---ELARRMNELSRDKDQLAPQFEDCVRSGKDL-------IS 5480
            .:..||.:... ||     |:||   |.:.|.|:   .::...|..|.......|.       :.
Human  4173 SDNSMAQILTP-DS-----LNTEQGPECSLRPNQ---TEEGTTPPIEADTLDSSDAQGGLEPRVE 4228

  Fly  5481 LRDVTDTGVL---RDRIKALESQWRNINISIDERAKLS--KQKAEQQLA---------------- 5524
            ......|.||   :.::..||...:..|::::.....:  :|..||||.                
Human  4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFL 4293

  Fly  5525 YEGLKDQVLSWLAST----EARVNGLPPVAIDLDRIKQQHDELKPICKDYRDYAPTIDKINDIGA 5585
            .|..|||.|....:|    ||....|..|..:|::::....|     |...|..|||.|.:....
Human  4294 LETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQE-----KHSEDQHPTILKKSSEPE 4353

  Fly  5586 QYDAL-------------IRPESPARKRSTYSPIKRTSPLRR----------------------- 5614
            ..:||             .||:...:|......:....|:.:                       
Human  4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDN 4418

  Fly  5615 -------MSGDARSP-SPTKGGILSPLSTGSSGFGSRRSSQDGFQL--SELS-----PVQQQLS- 5663
                   .|..|.|| :.....||||  .|.:|        |.:|.  .|||     |:.|.:. 
Human  4419 DTTQESSASNQASSPENDVPDSILSP--QGQNG--------DKWQYLHHELSSKIKLPLPQLVEP 4473

  Fly  5664 EINNRYGLIG--VRLNDRQHELDNLN------EELRKQYENLKGLAQFLERIQRQLPKESVSNKD 5720
            :::...|::.  ...|.|....:.|.      |:||::..||        :.|..:.:|:..|.|
Human  4474 QVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL--------QTQENMTEEAYINLD 4530

  Fly  5721 E--------AERCIKQARKIL-------EDMYEKQSLLDTTKAQVKDILRRKSDVPGAEQLR--- 5767
            :        ..:|:....::|       ||...:|...:|...::|.:....||..| :.|:   
Human  4531 KKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKG-DLLKAMT 4594

  Fly  5768 ---QENDSIQEKWKNLNDICKNR-----IAFSEKLRDFLDTHGNLKS--------WLDSKERMLT 5816
               :..:.:.|.:.|| .:|...     :..|:.|:..||.:.:.::        .:.||..:..
Human  4595 WPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ 4658

  Fly  5817 VLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVVDHLAGTPDAQAVEI-KLKDIL 5880
            .|..||.  :.|..|:|:......|....:.::...::.|..:  ||   |.|...|: ||:|:|
Human  4659 SLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERL--HL---PYALLQEVYKLEDVL 4716

  Fly  5881 GKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISDNLDTLPTDGDHQENLRKIENLE 5945
               |.:.|.|..|...|.....:..:.||.:..:.|.::...:.|    ..|..::...|:. |:
Human  4717 ---DSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKL----AHGHLKQTKSKVA-LQ 4773

  Fly  5946 RQLEGQR----PLLADV----EQSAATLCNILGDPAS-RADVNSRVAALEKQYLALQKKLDTKKA 6001
            .|:|..:    .|:||:    ..||..|.::|.:..: .|:..:.|..||::......||     
Human  4774 AQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKL----- 4833

  Fly  6002 ETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYREVMAREHEVI 6066
              ::.|:....|.||.:.....|...:|.|....||...:..|..:|..::.|.|.:..:...:.
Human  4834 --QSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLY 4896

  Fly  6067 MLINKGKDLTDRQQDRGVKRDLDRIQQQWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFLAWLR 6131
            ..:|:||.|........::..:.::::||..|.::......|||..::|...|::.|:....||.
Human  4897 QTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLE 4961

  Fly  6132 TAEDKLADLTPGVLSKAKLETRLRDLQTFRSEVWKHSGEFENTKGLGETFLSSCDIDKEPIKAEL 6196
            :::..|                         ..||.                             
Human  4962 SSQHTL-------------------------NYWKE----------------------------- 4972

  Fly  6197 QDIRDRWERLNNDLIARAHEIENCSRRLDDFNDELRNLDHSLGRCEDRLAAHDALGGAAKDPKLL 6261
            |.:                   |.|:.||.....:.|                          ..
Human  4973 QSL-------------------NVSQDLDTIRSNINN--------------------------FF 4992

  Fly  6262 ERVKAIREELTNLSKPLQSLKALAKDISAEARAAGGDADHLTSEVDGLADRMSELQGRLDDRCGE 6326
            |..|.:.|:        .|||.....|       |....|| .|.|....|.|            
Human  4993 EFSKEVDEK--------SSLKTAVISI-------GNQLLHL-KETDTATLRAS------------ 5029

  Fly  6327 LQSAATAVSQFNEQMKSLGIDLNDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRLED 6391
                   ::||.::...|...|.|::   |||.                   |.::::|      
Human  5030 -------LAQFEQKWTMLITQLPDIQ---EKLH-------------------QLQMEKL------ 5059

  Fly  6392 AERAADVLVDAGFAADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTLKALREFYDHQSQTLDD 6456
                              .:|:.|:.:...:..::::..| ||::||...|              
Human  5060 ------------------PSRKAITEMISWMNNVEHQTSD-EDSVHSPSSA-------------- 5091

  Fly  6457 IQDVSDEFKRMKPVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVST-- 6519
                           |::..:.::.::||...:.|    ...||.||   :.|::.:...|.:  
Human  5092 ---------------SQVKHLLQKHKEFRMEMDYK----QWIVDFVN---QSLLQLSTCDVESKR 5134

  Fly  6520 ---TAIEKDLEKLNDRWNDLKERMNERDRRLDVALLQSGKFQEALAGLSKWLSDTEEMVAN-QKP 6580
               |...:.|.::|.:|:.:...:|.:.:.|:..|....:.:..:..|:.||...||.:.. |||
Human  5135 YERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKP 5199

  Fly  6581 PSSDYKVVKAQLQEQKFLKKMLLDRQNSMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDAL 6645
            .|    |:..|        |:|||.|:                       ||.||....|..|.|
Human  5200 ES----VISVQ--------KLLLDCQD-----------------------IENQLAIKSKALDEL 5229

  Fly  6646 TDGAEQRELDLEEAMEVAKRFHDKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHDE 6710
                :|..|.||..  ......|..|.::.........:..:..:.|..:.:.|..:.:|:|:||
Human  5230 ----KQSYLTLESG--AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDE 5288

  Fly  6711 ILGKKPDFSDLADVTAQLMHLVSDEEAVNLG-EKVRGVTERYTGLVDASDNIGALLAESRQGLRH 6774
            :          ..:|.:..:.:...:.|.|. |.:|...|....|.|.        |||.:|   
Human  5289 V----------NMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE--------AESSEG--- 5332

  Fly  6775 LVLSYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGHASNVESTVESGAELMK 6839
                     :|                  |||.|.:..|..|..::              ||:  
Human  5333 ---------SW------------------EKLQEVIGKLKGLCPSV--------------AEI-- 5354

  Fly  6840 HISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAP 6904
                     :::|..:..:|:..:.....|.|:.||:.|.|.:.:..||         .|||   
Human  5355 ---------IEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH---------GEAA--- 5398

  Fly  6905 SEPRQADVLRLEGELADMRPILDSINQVGPQLCQLSPG--EGAATIESIVTRDNRRF---DSIVE 6964
                    .||:.:.|..:. |.:|:..|..|.::.|.  :....::..|.:....|   .|:::
Human  5399 --------ARLKQQEAKFQQ-LANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD 5454

  Fly  6965 QIQRKAER---------LHLSNQRAKEV-------TGDIDELLEWFREMDTTLREADLPAM--EP 7011
            ::.:.||.         || |.|||..:       ..:.:.:|..|::....|.......|  |.
Human  5455 RLPQPAESSTHMLLPGPLH-SLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE 5518

  Fly  7012 KLVRAQLQEHRSINDDISSQKGRVRDVTAASKKVLRESPQSE--NTATLREKLDDLK-------- 7066
            .|.|...||..  |.|  |....|..:||       :||..|  |..:|:..|.|:.        
Human  5519 NLDRLHQQEKE--NPD--SFLNHVLALTA-------QSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572

  Fly  7067 ----EIVDTVAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQIS---RLSMPALRPDQI 7124
                ....|..:.|||..||     .|:|.|....:.....|:.:|:.:.   ..|:|.|     
Human  5573 RQWIRATATALERCSELQGI-----GLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPEL----- 5627

  Fly  7125 TLQQDKNERLLQSIAEHKPLLDKLNKTGEALGALVADDDGAKINEILDTDNA------------- 7176
             |:|.|..::|::..       .:|:|       :||....:..::|||...             
Human  5628 -LEQQKTYKMLEAEV-------SINQT-------IADSYVTQSLQLLDTTEIENRPEFITEFSKL 5677

  Fly  7177 --RYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVNQLDPLSALPQKIREQIED 7239
              |:......:|:|:..::..:::...|:..:|.:.|.|.:|    :.|  |||:..:.|..:..
Human  5678 TDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT----SHL--LSAVKGQERFSLYQ 5736

  Fly  7240 NDALMDDLDKRQDAFSAVQRAANDVIAKAGNKADPAVRDIKAK------LEKLNNLWNDVQNATK 7298
            ..:|:.:|..::..|.. :|....:..:||.|. ....|:|.|      :.:|.:.|.|::   .
Human  5737 TRSLIHELKNKEIHFQR-RRTTCALTLEAGEKL-LLTTDLKTKESVGRRISQLQDSWKDME---P 5796

  Fly  7299 KRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQ--EPPAAQPQDIKKQQVALQEIRHEIDQ 7361
            :....:....|..|. |.|....:|.||...:.|..|  :|.....:|:..::..::|:...:..
Human  5797 QLAEMIKQFQSTVET-WDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLAS 5860

  Fly  7362 TKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREENLIDAMEKAMEFHET 7426
            ....:::::...::|.......|...:|:.||.|...|:::....|.|::.:.|.:...:.|:|.
Human  5861 WTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925

  Fly  7427 LQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQL-KSFKDEVDPHMVEVEALNRQAVELTERTS 7490
            .:.|..:|.:.|:|....    :|| :::..||:| |...:|::........|.:...:|.:.::
Human  5926 NKELCAWLVQMENKVLQT----ADI-SIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985

  Fly  7491 PEQAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLVWINKTDSTLDQLKP 7555
            ..:||.|.:.|:.:|.||:.|...:..|.|:|:.....:.|....::.|..|:.:.:|.|.  ||
Human  5986 KSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KP 6048

  Fly  7556 I---PGDPQLLEVELAKLKVLANDIQAHQNSVDT--------LNDAGRQLIETEKGSVEASTTQE 7609
            :   ..|.|.::..||:.:.|..||:.|...|::        |:|:.....|||..|::.:|   
Human  6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTT--- 6110

  Fly  7610 KLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGGLPETAT 7674
              |.|:..|:.:...:.:|:.::||..|....::.:......||...:...........|..:|.
Human  6111 --RSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAK 6173

  Fly  7675 EQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRASDK 7739
            |:|:||.....::.|...::|.|..|.:. :.|:|:.. ::|.|:..:....||||.:..|.:..
Human  6174 EELKRFEAFQRQIHERLTQLELINKQYRR-LARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAV 6236

  Fly  7740 KIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHREA 7804
            ..:|.....:..||..|.::.:.|||:.:..|:|.|..|.  .....:|.:....|::::.:...
Human  6237 LRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE--SDADDKMRQLNGFQQEITLNTNK 6299

  Fly  7805 MLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERV---VSKAAERTRALDHGYKEAREFN--- 7863
            :..|...|..|...|:..|.:||::.|..:....:.|   ||:...|..:...|.::.:|.:   
Human  6300 IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENE 6364

  Fly  7864 -----------DAW-------------------------SGMMQYLQETEQVLDQIIEE------ 7886
                       |:|                         ||.     ||...:|.|..|      
Human  6365 TDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGC-----ETPVSVDSIPLEWDHTGD 6424

  Fly  7887 --ATASKE----------------PQKIKKYIGKLKETHRQLGAK--QSVYDG------------ 7919
              .::|.|                |:..:.|   ||.|.:.|.|.  :|:.||            
Human  6425 VGGSSSHEEDEEGPYYSALSDVEIPENPEAY---LKMTTKTLKASSGKSISDGHSWHVPDSPSCP 6486

  Fly  7920 -----TMRTGKNLLERAPKGD---RPVLDKMLIE--------------------------LKEQ- 7949
                 .|...:|:....|...   :|...|:|:.                          :.|| 
Human  6487 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQ 6551

  Fly  7950 --------------------WTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNE 7994
                                |..:.::.:..:.|:::.|   .|.:..:..:..||||.::    
Human  6552 SGTACNWQSSREAEYGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA---- 6609

  Fly  7995 NGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLK---TGRDLERSGN-------------NP 8043
                  :||.:: :.:....| |:::.|..::|.:||   |.:.|..|.|             :.
Human  6610 ------ELEMLK-MAKPPSDI-QEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPEST 6666

  Fly  8044 EVGRQLDEMQSIWEEVKSAVA--KRGERLQVALVDAEKLNARVQALFD------------WLDHA 8094
            |:..:|.::..:||..:.||.  :.|.|..:......|...|...||.            ||..|
Human  6667 ELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASA 6731

  Fly  8095 EHKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLS 8159
            ::: |...:..|.:...|.:::...:.|:    .|:|..|         .:...|.:..|.|.| 
Human  6732 KNR-RQKAHVTDPKADPRALLECRRELMQ----LEKELVE---------RQPQVDMLQEISNSL- 6781

  Fly  8160 IIQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLP--DEI--- 8219
            :|:...|:    .|..|.|:....:.||.|.:.:.:.|..|.|.:...     ..||  ||:   
Human  6782 LIKGHGED----CIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA-----SPLPSFDEVDSG 6837

  Fly  8220 --PPVEKLIEDH-KEFMENTARRQNEVDRACKPRQLPPGARKPSRS 8262
              ||...:.... |:|   .|.|..|.:...:.|  .||:.:|.||
Human  6838 DQPPATSVPAPRAKQF---RAVRTTEGEEETESR--VPGSTRPQRS 6878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
shotNP_725339.1 SAC6 204..>420 CDD:227401 70/216 (32%)
CH_PLEC-like_rpt2 223..327 CDD:409038 49/103 (48%)
SPEC 471..689 CDD:238103 36/236 (15%)
SPEC 690..866 CDD:238103 25/176 (14%)
SH3_10 864..929 CDD:407754 8/64 (13%)
SPEC 1047..1250 CDD:238103 41/204 (20%)
SPEC 1153..1390 CDD:238103 47/249 (19%)
PLEC <1498..1526 CDD:197605 0/27 (0%)
Plectin 1949..1980 CDD:459901 5/30 (17%)
DUF5585 2860..>3198 CDD:465521 73/387 (19%)
SMC_prok_B <4936..>5564 CDD:274008 152/751 (20%)
SPEC 5304..5513 CDD:238103 48/246 (20%)
SPEC <5658..5787 CDD:413338 29/158 (18%)
SPEC 5793..6007 CDD:238103 49/231 (21%)
SPEC 6011..6220 CDD:238103 31/208 (15%)
SPEC 6118..6330 CDD:238103 27/211 (13%)
PRK09039 <6279..6441 CDD:181619 28/161 (17%)
SPEC 6443..6660 CDD:238103 44/222 (20%)
SPEC 6663..6878 CDD:238103 35/215 (16%)
SPEC 6880..7087 CDD:238103 53/243 (22%)
SPEC 6986..7196 CDD:238103 50/243 (21%)
SPEC 7196..7417 CDD:238103 45/228 (20%)
SPEC 7314..7526 CDD:238103 46/214 (21%)
SPEC 7528..7747 CDD:238103 52/229 (23%)
SPEC 7749..7968 CDD:238103 57/353 (16%)
SPEC 7973..8181 CDD:238103 48/237 (20%)
FRQ1 <8375..8444 CDD:444056
GAS2 8450..8522 CDD:128539
PHA03307 8550..>8795 CDD:223039
SYNE2XP_011534876.1 CH_SYNE2_rpt1 28..138 CDD:409091 1/1 (100%)
CH_SYNE2_rpt2 178..286 CDD:409093 50/117 (43%)
PRK03918 <1418..2014 CDD:235175 137/813 (17%)
PRK03918 <1868..>2369 CDD:235175 102/565 (18%)
SMC_N <2338..2712 CDD:481474 77/475 (16%)
CCDC158 2805..>3389 CDD:464943 147/911 (16%)
SMC_N <3656..>3950 CDD:481474 65/337 (19%)
SMC_N <3811..4113 CDD:481474 73/335 (22%)
SMC_prok_B <4496..5321 CDD:274008 202/1124 (18%)
SPEC 4945..5169 CDD:238103 62/440 (14%)
SPEC 5063..5276 CDD:238103 54/290 (19%)
SMC_prok_B 5123..>5875 CDD:274008 181/935 (19%)
SPEC 5178..5384 CDD:413338 62/319 (19%)
SPEC 5919..6133 CDD:238103 53/225 (24%)
SPEC 6137..6350 CDD:238103 46/216 (21%)
SPEC 6590..6813 CDD:238103 52/256 (20%)
KASH <6905..6936 CDD:463142
Blue background indicates that the domain is not in the aligned region.

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