Protein Alignment Uba3 and NAE1

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001273429.1
• Gene: NAE1 / 8883
• HGNCID: 621
• Length: 537
• Species: Homo sapiens
• Alignment Length: 425
• Identity: 94/425 - (22%)
• Similarity: 151/425 - (35%)
• Gaps: 125/425 - (29%)

  Fly    40 ENLEFLQTKCQVLIIGAGGLGCELLKDLAL---MGFGNLHVIDMDTIELSNLNRQFLFRRTDIGA 101
            |.||    ...|.:|.|...|.|:||:|.|   :|.|:..:||.:.:...:....|..:|:.||.
Human    26 EALE----SAHVCLINATATGTEILKNLVLPGNVGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGK 86

  Fly   102 SKAECAARF---INARVPTCRVTPHFKKIQDFDESFYQQFHLVVC-GLDSIVARRWINGMLLSML 162
            ::||.|..|   :|:.|....|....:.:.|.|.||:.:|.:||. .|....:.|     |..:|
Human    87 NRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLR-----LADVL 146

  Fly   163 RYEEDGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPE 227
                     .:|.:|::...|.|..|..|:|:....     .::..|......|......|.|.|
Human   147 ---------WNSQIPLLICRTYGLVGYMRIIIKEHP-----VIESHPDNALEDLRLDKPFPELRE 197

  Fly   228 HCIEYVKIIQWEKQNPFGVPLDGDDPQHIGWIYERALERSNEFNITGVTYRLVQGVVKHIIPAVA 292
            |...| .:...||:          |..|..||..                     :.|::....:
Human   198 HFQSY-DLDHMEKK----------DHSHTPWIVI---------------------IAKYLAQWYS 230

  Fly   293 STNAAIAAACALEVFKLATSCYDSMANYLNFNDL--DGIYTYTYEAEKSE--------NCLACSN 347
            .||..|.     :.:|          ...:|.||  .||......|.:.|        |.....|
Human   231 ETNGRIP-----KTYK----------EKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALN 280

  Fly   348 TPQPLPIEDPNTTTLEDV------IKLLCDSPRFQLKSPALTT-VMKDGK-----RRTL------ 394
            |.| :|      :::||:      |.:...:|.|.:.:.||.. |.|:|:     |.|:
Human   281 TTQ-IP------SSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIAD 338

  Fly   395 ---YMSGVKSIEEATRKN----------LTQSLGE 416
               |:.......|..:|:          |.||:|:
Human   339 SGKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQ 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	68/312 (22%)
		E2_bind	357..442	CDD:462611	19/91 (21%)
NAE1	NP_001273429.1	APPBP1_RUB	11..535	CDD:238770	94/425 (22%)
		Interaction with UBA3	334..347		1/12 (8%)