DRSC/TRiP Functional Genomics Resources

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Protein Alignment Uba3 and UBA5

DIOPT Version :10

Sequence 1:NP_610913.1 Gene:Uba3 / 36539 FlyBaseID:FBgn0263697 Length:450 Species:Drosophila melanogaster
Sequence 2:NP_079094.1 Gene:UBA5 / 79876 HGNCID:23230 Length:404 Species:Homo sapiens


Alignment Length:415 Identity:84/415 - (20%)
Similarity:145/415 - (34%) Gaps:121/415 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 VLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFI---- 111
            |.|:|.||:|....:.|...|.|.|.:.|.|.:||:|:||.| |:....|.||.:.|...:    
Human    76 VAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHTLRNIN 139

  Fly   112 --------NARVPTCRVTPHF-KKIQDFDESFYQQFHLVVCGLDSIVARRWINGMLLSM-LRYEE 166
                    |..:.|.....|| .:|.:......:...||:..:|:..||..||.....: ..:.|
Human   140 PDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWME 204

  Fly   167 DGTIDTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEHCIE 231
            .|..:.:            ..|:.::|:||.:||..|.     |    ||...||          
Human   205 SGVSENA------------VSGHIQLIIPGESACFACA-----P----PLVVAAN---------- 238

  Fly   232 YVKIIQWEKQNPFGVPLDGDDPQHIGWIYERALERSNEFNITGVTYRLVQGVVKHIIPAVASTNA 296
                                       |.|:.|:|              :||....:|   :|..
Human   239 ---------------------------IDEKTLKR--------------EGVCAASLP---TTMG 259

  Fly   297 AIAAACALEVFKLATSCYDSMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPN-TT 360
            .:|......|.|...: :.:::.||.:|.:...:.            ..|..|.| ..:|.| ..
Human   260 VVAGILVQNVLKFLLN-FGTVSFYLGYNAMQDFFP------------TMSMKPNP-QCDDRNCRK 310

  Fly   361 TLEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGEL-GLHDGQQ 424
            ..|:..|.:...|:.::.......:.:|.:      .|::.:.|.:.:.|....|.: .|.:|  
Human   311 QQEEYKKKVAALPKQEVIQEEEEIIHEDNE------WGIELVSEVSEEELKNFSGPVPDLPEG-- 367

  Fly   425 LTVTDATSPSAMTLQLKYQSNEVEM 449
            :||       |.|:..|.:.:..|:
Human   368 ITV-------AYTIPKKQEDSVTEL 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Uba3NP_610913.1 Uba3_RUB 50..346 CDD:238765 63/308 (20%)
E2_bind 357..442 CDD:462611 15/86 (17%)
UBA5NP_079094.1 ThiF_MoeB_HesA_family 52..297 CDD:238386 63/309 (20%)
UFM1-interacting sequence (UIS). /evidence=ECO:0000269|PubMed:26929408, ECO:0000269|PubMed:27653677 334..346 2/17 (12%)
Linker. /evidence=ECO:0000269|PubMed:34588452 347..377 9/38 (24%)
UFC1-binding sequence (UFC). /evidence=ECO:0000269|PubMed:34588452 389..404
Blue background indicates that the domain is not in the aligned region.

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