Protein Alignment Uba3 and UBA7

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_003326.2
• Gene: UBA7 / 7318
• HGNCID: 12471
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 650
• Identity: 136/650 - (20%)
• Similarity: 200/650 - (30%)
• Gaps: 266/650 - (40%)

  Fly     6 PNPGLILQSKRFNGLRNILEREGPFCKDGFAASSENLEFLQTKCQVLIIGAGGLGCELLKDLALM 70
            |..|.:|.|.....||. ...:|.....| |...|.|.    :...|::|||.:||||||..||:
Human   396 PEDGELLPSPEDCALRG-SRYDGQIAVFG-AGFQEKLR----RQHYLLVGAGAIGCELLKVFALV 454

  Fly    71 GF-----GNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECAARFINARVPTCRVTP-------- 122
            |.     |.|.|:|||.||.|||:||||||..|:|..|||.||.......|..:|.|
Human   455 GLGAGNSGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAARGLNPDLQVIPLTYPLDPT 519

  Fly   123 --HFKKIQDFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLRYEEDGTIDTSSIVPMIDGGTEG 185
              |.     :.::|:.:...|...|||..|||::.......|:             |:::.||.|
Human   520 TEHI-----YGDNFFSRVDGVAAALDSFQARRYVAARCTHYLK-------------PLLEAGTSG 566

  Fly   186 FKGNARVILPGFTACIECTLDLFPPQ-VNYPLCTIANTPRLPEHCIEYVK--------------- 234
            ..|:|.|.:|..|............: ..||:||:...|...||.:::.:
Human   567 TWGSATVFMPHVTEAYRAPASAAASEDAPYPVCTVRYFPSTAEHTLQWARHEFEELFRLSAETIN 631

  Fly   235 -------------------------------------IIQW------------------------ 238
                                                 .:.|
Human   632 HHQQAHTSLADMDEPQTLTLLKPVLGVLRVRPQNWQDCVAWALGHWKLCFHYGIKQLLRHFPPNK 696

  Fly   239 --EKQNPF-----------------------------------GVP--------------LDGDD 252
              |...||                                   |:|              |...|
Human   697 VLEDGTPFWSGPKQCPQPLEFDTNQDTHLLYVLAAANLYAQMHGLPGSQDWTALRELLKLLPQPD 761

  Fly   253 PQ-----------------------------------------------------HIGWIYERAL 264
            ||                                                     |:.::...|.
Human   762 PQQMAPIFASNLELASASAEFGPEQQKELNKALEVWSVGPPLKPLMFEKDDDSNFHVDFVVAAAS 826

  Fly   265 ERSNEFNITGVTYRLVQGVVKHIIPAVASTNAAIAAACALEVFKLATS--------------CYD 315
            .|...:.|..|.....:.:|..||||:|:|.||:|....||::|:.:.              ..:
Human   827 LRCQNYGIPPVNRAQSKRIVGQIIPAIATTTAAVAGLLGLELYKVVSGPRPRSAFRHSYLHLAEN 891

  Fly   316 SMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPNTTTLEDVIKLLCDS----PRFQ 376
            .:..|:.|  ...|.|:.:....|.:.|       .:|...|. .|||.::..|.:.    .|..
Human   892 YLIRYMPF--APAIQTFHHLKWTSWDRL-------KVPAGQPE-RTLESLLAHLQEQHGLRVRIL 946

  Fly   377 LKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQQLTVTDATSPSAMTLQLK 441
            |...||           ||.:|....::|  ::|...:.||    .|||| ..|.:|....|.|:
Human   947 LHGSAL-----------LYAAGWSPEKQA--QHLPLRVTEL----VQQLT-GQAPAPGQRVLVLE 993

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	100/505 (20%)
		E2_bind	357..442	CDD:462611	24/88 (27%)
UBA7	NP_003326.2	Ube1	10..1010	CDD:273603	136/649 (21%)
		2 approximate repeats	23..575		68/202 (34%)