Protein Alignment Uba3 and uba-2

DIOPT Version :10

• Sequence 1: NP_610913.1
• Gene: Uba3 / 36539
• FlyBaseID: FBgn0263697
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001293154.1
• Gene: uba-2 / 24104970
• WormBaseID: WBGene00006700
• Length: 582
• Species: Caenorhabditis elegans
• Alignment Length: 538
• Identity: 130/538 - (24%)
• Similarity: 200/538 - (37%)
• Gaps: 165/538 - (30%)

  Fly    43 EFLQTKCQVLIIGAGGLGCELLKDLALMGFGNLHVIDMDTIELSNLNRQFLFRRTDIGASKAECA 107
            :.:|:|  :|:|||||:||||||:||:.||..:||||:|||::||||||||||:..:.:|||..|
 Worm    10 KIVQSK--ILVIGAGGIGCELLKNLAVTGFRKVHVIDLDTIDISNLNRQFLFRKEHVSSSKAATA 72

  Fly   108 ARFINARVPTCRVTPHFKKI--QDFDESFYQQFHLVVCGLDSIVARRWINGMLLSMLRYEEDGTI 170
            .:.:....|...:|.....|  :.::..|:|.:.:|:..||:..||.::|.|..:..|
 Worm    73 TQVVKQFCPQIELTFDHDSIFEKKYNMEFFQAYDIVLNALDNRAARNYVNRMCHAANR------- 130

  Fly   171 DTSSIVPMIDGGTEGFKGNARVILPGFTACIECTLDLFPPQVNYPLCTIANTPRLPEHCIEYVKI 235
                  |:||.|:.|:.|...||:.|.|.|.|| :|....|..||.|||.|||....||..:.|.
 Worm   131 ------PLIDSGSGGYFGQVSVIMRGKTECYEC-VDKPVQQTTYPGCTIRNTPSEHIHCTVWAKH 188

  Fly   236 I------------------------------------------------QWE------------- 239
            :                                                ||.
 Worm   189 VFNQLFGEVDIDDDVSPDMDAVDPDNTEAVTTEKEKEAMKEEPAPVGTRQWAESVDYDAAKVFDK 253

  Fly   240 ----------------KQNPFGVPLD-------GDDPQHIG---------W-------IYERALE 265
                            ||.....||:       |.:||.:.         |       ::...::
 Worm   254 LFLHDIEYLCKMEHLWKQRKRPSPLEFHTASSTGGEPQSLCDAQRDDTSIWTLSTCAKVFSTCIQ 318

  Fly   266 ---------------------------------RSNEFNITGVTYRLVQGVVKHIIPAVASTNAA 297
                                             |:..|.|...:...::.:..:||||:|||||.
 Worm   319 ELLEQIRAEPDVKLAFDKDHAIIMSFVAACANIRAKIFGIPMKSQFDIKAMAGNIIPAIASTNAI 383

  Fly   298 IAAACALEVFKL----ATSCYDSMANYLNFNDLDGIYTYTYEAEKSENCLACSNTPQPLPIEDPN 358
            :|.....|..::    ...|..|:|. ...|....|:........:..|..||...:.....:|:
 Worm   384 VAGIIVTEAVRVIEGSTVICNSSIAT-TQSNPRGRIFGGDATNPPNPRCFVCSEKREVFIYVNPD 447

  Fly   359 TTTLEDVIKLLCDSPRFQLKSPALTTVMKDGKRRTLYMSGVKSIEEATRKNLTQSLGELGLHDGQ 423
            |.|:..    ||:....|..:.....||.....|.:..|     :..|...|.:.|.|:.:.||.
 Worm   448 TMTVGG----LCEKVLKQKLNMLAPDVMDSATSRIIVSS-----DGDTDDLLPKKLAEVSIEDGA 503

  Fly   424 QLTVTDATSPSAMTLQLK 441
            .|:..|......:.|.:|
 Worm   504 ILSCDDFQQEMEIKLFIK 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba3	NP_610913.1	Uba3_RUB	50..346	CDD:238765	106/434 (24%)
		E2_bind	357..442	CDD:462611	20/85 (24%)
uba-2	NP_001293154.1	E1_enzyme_family	15..434	CDD:451392	107/435 (25%)
		UAE_UbL	442..526	CDD:464286	20/89 (22%)