Protein Alignment Dp and TFDP2

DIOPT Version :10

• Sequence 1: NP_477039.1
• Gene: Dp / 36461
• FlyBaseID: FBgn0011763
• Length: 445
• Species: Drosophila melanogaster
• Sequence 2: NP_001362702.1
• Gene: TFDP2 / 7029
• HGNCID: 11751
• Length: 447
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 174/407 - (42%)
• Similarity: 234/407 - (57%)
• Gaps: 63/407 - (15%)

  Fly    91 IPKT------EAGTTYTTVSAQKTSGAGSGHYDLPLKGDRYVKFTPNPIKMKSKLHAIQS----- 144
            :|||      ..|......:.|:.:.:||     .|.|..|   ||.| .|.::.|..::
Human    47 LPKTLGPINVNVGPQMIISTPQRLTSSGS-----VLIGSPY---TPAP-AMVTQTHIAEATGWVP 102

  Fly   145 ----NSLHSMSASSSSVQRKRKPDKAGKGLRHFSMKVCEKVEEKGKTTYNEVADDLVSEEMKNN- 204
                .:...:.:..|..:|.:|.||.|||||||||||||||:.||.|:||||||:||||...:|
Human   103 GDRKRARKFIDSDFSESKRSKKGDKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVSEFTNSNN 167

  Fly   205 --AYDNNC-DQKNIRRRVYDALNVLMAINVISKDKKEIRWIGLPANSTETFLALEEENCQRRERI 266
              |.|:.. ||||||||||||||||||:|:|||:||||:|||||.||.:....||.|..:|.|||
Human   168 HLAADSQAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEIEKQRRIERI 232

  Fly   267 KQKNEMLREMIMQHVAFKGLVERNKRNESQGV-VPSPNASIQLPFIIVNTHKSTKINCSVTNDKS 330
            |||...|:|:::|.:|||.||:||::||.|.. .|:.|::|||||||:||.:.|.|:||:::||.
Human   233 KQKRAQLQELLLQQIAFKNLVQRNRQNEQQNQGPPALNSTIQLPFIIINTSRKTVIDCSISSDKF 297

  Fly   331 EYIFKFDKTFEMHDDIEVLKRMGFLLGLDKGECTPENIERVKSWVPPNLAKYVEAYGTG------ 389
            ||:|.||.|||:|||||||||||...||:.|:|:.|:::..||.||..|..|:....||
Human   298 EYLFNFDNTFEIHDDIEVLKRMGMSFGLESGKCSLEDLKLAKSLVPKALEGYITDISTGPSWLNQ 362

  Fly   390 ---------------KTGENMYES--------DDEDNEFNGYLESANESQGFAQHSAQHTTD--G 429
                           .||..:.:|        |.|.....|...:.|..|  :..:|.|.::  |
Human   363 GLLLNSTQSVSNLDLTTGATLPQSSVNQGLCLDAEVALATGQFLAPNSHQ--SSSAASHCSESRG 425

  Fly   430 EFKLEM-DDDELDDDID 445
            |..... |:||.||:.|
Human   426 ETPCSFNDEDEEDDEED 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dp	NP_477039.1	E2F_TDP	167..243	CDD:460530	58/79 (73%)
		coiled coil	248..294	CDD:271217	21/45 (47%)
		DP	255..386	CDD:462601	70/131 (53%)
TFDP2	NP_001362702.1	Interaction with CEBPA. /evidence=ECO:0000269|PubMed:20176812	60..82		5/26 (19%)
		Nuclear localization signal. /evidence=ECO:0000250	103..118		0/14 (0%)
		E2F_TDP	128..209	CDD:460530	58/80 (73%)
		DEF box	177..211		29/33 (88%)
		coiled coil	214..260	CDD:271217	21/45 (47%)
		DP	216..354	CDD:462601	70/137 (51%)
		Dimerization. /evidence=ECO:0000255	220..293		38/72 (53%)
		DCB1	230..262		18/31 (58%)
		DCB2	275..331		35/55 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..447		11/35 (31%)