Protein Alignment Su(z)2 and PCGF3

DIOPT Version :10

• Sequence 1: NP_001260933.1
• Gene: Su(z)2 / 36432
• FlyBaseID: FBgn0265623
• Length: 1396
• Species: Drosophila melanogaster
• Sequence 2: NP_006306.2
• Gene: PCGF3 / 10336
• HGNCID: 10066
• Length: 242
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 63/232 - (27%)
• Similarity: 110/232 - (47%)
• Gaps: 46/232 - (19%)

  Fly    33 ITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINELNLKSDDTLRSLIY 97
            ||||||.||:||.|||..|.||:||||::|:|.....||.|:....:......:..|.|::.::|
Human    15 ITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVY 79

  Fly    98 KLVPGLYQRECKELADF------------------KEQH-----------------DLVDEQTTD 127
            ||||||.:.|.::..:|                  .:||                 :..:|:..:
Human    80 KLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEE 144

  Fly   128 EPEFFTTTELISLSLEYHPAMLHQCGPGEVPPTIYLQCAAGLPVELLKRFLCSKYNIETDNGLVE 192
            :.::..:.|.:|:.||.:.:.|...      ...:::|:|...|..||:|:..|.|:.:.|   |
Human   145 DNDYHRSDEQVSICLECNSSKLRGL------KRKWIRCSAQATVLHLKKFIAKKLNLSSFN---E 200

  Fly   193 VEVTYKDEVLPTNFTLMDVAYCYNWS-RESPMAFCYR 228
            :::...:|:|..:.||..|... .|. :::|:...||
Human   201 LDILCNEEILGKDHTLKFVVVT-RWRFKKAPLLLHYR 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Su(z)2	NP_001260933.1	RING-HC_PCGF5	23..117	CDD:438395	36/101 (36%)
		RAWUL_PCGF2_like	137..228	CDD:340602	21/91 (23%)
PCGF3	NP_006306.2	RING-HC_PCGF3	4..69	CDD:438393	25/53 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..149		3/33 (9%)
		Interaction with BCORL1. /evidence=ECO:0000269|PubMed:27568929	132..242		25/115 (22%)
		RAWUL_PCGF3	154..236	CDD:340603	21/91 (23%)