Protein Alignment Mdr49 and Abcb1a

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_035206.2
• Gene: Abcb1a / 18671
• MGIID: 97570
• Length: 1276
• Species: Mus musculus
• Alignment Length: 1303
• Identity: 549/1303 - (42%)
• Similarity: 790/1303 - (60%)
• Gaps: 100/1303 - (7%)

  Fly    30 SYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFG 94
            |...:|||:...:|..::|..|.|......:|..|:|:|:.|    |....||
Mouse    34 SVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMT----DSFASVG------------ 82

  Fly    95 GGQQLTNASKEENNQAIIDDATAF---------------GIGSLVGSVAMFLLITLAIDLANRIA 144
                  |.||...|.:..|....|               |||:.|..|| ::.::.....|.|
Mouse    83 ------NVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVA-YIQVSFWCLAAGR-- 138

  Fly   145 LNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIV 209
              ||.:||:.|..|::.|:|.|:|........:::|:|:.|:.||||:||.:....:.||..|.:
Mouse   139 --QIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFI 201

  Fly   210 SAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQ 274
            ..|..|||||||:|:..|.:..:..:.|::..|..:|||.:|:.|..|.|||.:.||||.||.||
Mouse   202 IGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQ 266

  Fly   275 EKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPA 339
            :||.||:...|..|:..|.||.:.:.:....::|:||...|||.|||.:|::.:.      |:..
Mouse   267 KKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKE------YSIG 325

  Fly   340 VLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRF 404
            .::.|.|:|::||.::|.|||::||.|.|..|...:|.|||....:|...:.|::|:|..|::.|
Mouse   326 QVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEF 390

  Fly   405 EGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLR 469
            :.|.|.||:|.:|:|||||.:.|..|||||.||.|||||||.:|||||.|||..|.|.:||:|:|
Mouse   391 KNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIR 455

  Fly   470 TLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQV 534
            |:||.:||..||||.||||||||||.|||||||...|..:||||.:.||.:|||.:||..:||.|
Mouse   456 TINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLV 520

  Fly   535 GEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRL 599
            ||:|||:||||||||||||||||.|::|||||||||||..||..||:||:.|.:|.||:|:||||
Mouse   521 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRL 585

  Fly   600 STITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLS 664
            ||:.|||.|.....||:.|||.|:|||..:|:|.:|| :||           .||..::    |.
Mouse   586 STVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLV-MTQ-----------TAGNEIE----LG 634

  Fly   665 DEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRR---------KKKKDKEV----V 716
            :|.....:|.:..|.        ||:|||   |:..:|||.|:         :|...||.    |
Mouse   635 NEACKSKDEIDNLDM--------SSKDSG---SSLIRRRSTRKSICGPHDQDRKLSTKEALDEDV 688

  Fly   717 SKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSD-GDDDVVRAEVLKISM 780
            ...||.:::||||.||.:.|||...::::|...|.:.:.|....|:.:: |..:..|......|:
Mouse   689 PPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSL 753

  Fly   781 IFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDC 845
            :|:.:|:::.:...||.:.|..||..:|.|||...|.:::.||:::|||.:|:.|||.:|||:|.
Mouse   754 LFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDA 818

  Fly   846 SNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAK 910
            :.|:||||:|:..:.|.:|.|..|:::..::.||.|||.|..:|::.::..:|.:.:...|.|.|
Mouse   819 AQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDK 883

  Fly   911 ASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLA 975
            ..:|.:.::|.|||.|.|||..|..|::....|.|.:........:|....|:.|:..||..:.:
Mouse   884 KELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFS 948

  Fly   976 YGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTST 1040
            |.....:|..||.::.|.:|:::.|..|::||:..:||..::||:...|.:||..::.:.::|
Mouse   949 YAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKT-- 1011

  Fly  1041 QPNPPQSPYNT----VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKS 1101
               |....|:|    ....||::.:..|.|.||||...|:||||:|.:||..|:||||.||.|||
Mouse  1012 ---PEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKS 1073

  Fly  1102 TCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVS 1166
            |.||||.|:|||::|||.|.|....:..:..||::||:|||||:|||.:||||||||:|.| .||
Mouse  1074 TVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSR-VVS 1137

  Fly  1167 MQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSAL 1230
            .:||:.|||::|||.||.:||..|:||:| |.:||||||||||||||||||.|.||:||||||||
Mouse  1138 YEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSAL 1202

  Fly  1231 DLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLY 1295
            |.|||||||:|||:||.||||:.|||||:|::|||||.|::.|.|.|||||.:|:|...||.::.
Mouse  1203 DTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMV 1267

  Fly  1296 LMQ 1298
            .:|
Mouse  1268 SVQ 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	270/613 (44%)
		MdlB	720..1299	CDD:440747	254/585 (43%)
Abcb1a	NP_035206.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		PTZ00265	47..1263	CDD:240339	542/1281 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..681		12/45 (27%)