DRSC/TRiP Functional Genomics Resources

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Protein Alignment: Sans and USH1G

Sequence 1:NP_610829.1 Gene:Sans FlyBaseID:FBgn0033785 Length:516 Species:Drosophila melanogaster
Sequence 2:NP_775748.2 Gene:USH1G HGNCID:16356 Length:461 Species:Homo sapiens

Alignment Length:549 Identity:178/550 (32%)
Similarity:268/550 (49%) Gaps:124/550 (23%)


  Fly     3 SDRFHKAAKDGLLDVLAAATRKDTNAKDSDSMTPVMWAAFEGRLDALRLLCGRGGDPDKCDQFGN 67
            :|::|:||:||.|::|..||||:.||.|.|.|||.:|||:.|.|::|||:..|||||||||.:||
Human     2 NDQYHRAARDGYLELLKEATRKELNAPDEDGMTPTLWAAYHGNLESLRLIVSRGGDPDKCDIWGN 66

  Fly    68 TALHLASAKGHLHCVDFLVKFGVNIYALDIDKHSAKDLAAINGRDEILRYLDVAFTNFEATEKKK 132
            |.||||::.|||||:.|||.||.||:.||.|.|:..|:||:.|..|.:||||.......:...|.
Human    67 TPLHLAASNGHLHCLSFLVSFGANIWCLDNDYHTPLDMAAMKGHMECVRYLDSIAAKQSSLNPKL 131

  Fly   133 SKALKELAEKNCEKRVREYMKRQNQQQQRQDPEY-------SDLSAPSGSSKTGNMLS------T 184
            ...||:.|.:..|:|:||..|.|.:..:|.:..|       ||  ..|.||.|.:.||      .
Human   132 VGKLKDKAFREAERRIRECAKLQRRHHERMERRYRRELAERSD--TLSFSSLTSSTLSRRLQHLA 194

  Fly   185 LKQKIWSSQGNLNKTPRDTPPPTKFSDLVGNGSSSSGGSTIASRAGTVQKRPSQLQKQHSSTCPH 249
            |...:..||..|:.|                           :|..|..::..:.:||..     
Human   195 LGSHLPYSQATLHGT---------------------------ARGKTKMQKKLERRKQGG----- 227

  Fly   250 SKISSDTDGGFKVREVEPDGKRTITSLTGLQRDSEVLYV--GTFSSNEDSVGKRGKISDVFECME 312
                   :|.|||.|   ||:::..||:|||..|:|::|  ||:::.::  ..|..:.|:|    
Human   228 -------EGTFKVSE---DGRKSARSLSGLQLGSDVMFVRQGTYANPKE--WGRAPLRDMF---- 276

  Fly   313 ADELDHSDNRSGYSSTLARSFSQPDILGDGQLTQELSEEVTLQRPVGLFDRPTMLGSIAFRRSVT 377
                 .||..|...:|||...:..::..|....             .||.||. ||::.|||:..
Human   277 -----LSDEDSVSRATLAAEPAHSEVSTDSGHD-------------SLFTRPG-LGTMVFRRNYL 322

  Fly   378 AALSQLQLHTDTSSTSTMRNAGSNPPKTRNGGG-------KGRLYLNLSDDTDSEGGGHDI---- 431
                          :|.:...|      |..||       :|||..:.|.|.||.|..:.:    
Human   323 --------------SSGLHGLG------REDGGLDGVGAPRGRLQSSPSLDDDSLGSANSLQDRS 367

  Fly   432 ------YSDDD---DDDRDAGGSALQRFLAVWALEEYLPVFQKQEIDLETLMLLTESDLKSLGLP 487
                  :.:.|   |:|.:...|.|:.|||...:|::..:.::::||||.|||.::.||:|:.:|
Human   368 CGEELPWDELDLGLDEDLEPETSPLETFLASLHMEDFAALLRQEKIDLEALMLCSDLDLRSISVP 432

  Fly   488 LGPFRKLTFAIQERRNALANPGPLVDSRL 516
            |||.:|:..|::.||.|:..|..|.|:.|
Human   433 LGPRKKILGAVRRRRQAMERPPALEDTEL 461

Known Domains:


GeneSequenceDomainRegion External IDIdentity
SansNP_610829.1 ANK 6..118 CDD:238125 65/112 (58%)
Ank_2 6..96 CDD:289560 55/90 (61%)
ANK repeat 35..63 CDD:293786 18/28 (64%)
ANK repeat 65..96 CDD:293786 20/31 (65%)
Ank_2 70..149 CDD:289560 35/79 (44%)
SAM_USH1G_HARP 443..508 CDD:188916 25/65 (38%)
SAM 447..503 CDD:197735 23/56 (41%)
USH1GNP_775748.2 ANK 6..117 CDD:238125 65/111 (59%)
ANK repeat 31..62 CDD:293786 20/31 (65%)
ANK 1 31..60 18/29 (62%)
ANK repeat 64..95 CDD:293786 20/31 (65%)
ANK 2 64..93 19/29 (66%)
ANK 3 97..126 11/29 (38%)
SAM_USH1G 388..453 CDD:188985 25/65 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 C5747680
eggNOG 1 0.900 E33208_3BEMZ
Hieranoid 1 1.000
Homologene 1 1.000 H56113
Inparanoid 1 1.050 234 1.000 Inparanoid score I3356
Isobase 00.000 Not matched by this tool.
OMA 1 1.010
OrthoDB 1 1.010 D1344159at2759
OrthoFinder 1 1.000 FOG0005514
OrthoInspector 1 1.000 T609165
orthoMCL 1 0.900 OOG5_135035
Panther 1 1.100 O PTHR24161
Phylome 1 0.910 0.800 Consistency score
RoundUp 1 1.030 avgDist Average_Evolutionary_Distance R5090
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
1413.800

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