Protein Alignment Nacalpha and NACA

DIOPT Version :10

• Sequence 1: NP_477216.1
• Gene: Nacalpha / 36409
• FlyBaseID: FBgn0086904
• Length: 217
• Species: Drosophila melanogaster
• Sequence 2: NP_001352825.1
• Gene: NACA / 4666
• HGNCID: 7629
• Length: 2078
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 132/215 - (61%)
• Similarity: 155/215 - (72%)
• Gaps: 8/215 - (3%)

  Fly     8 KSEAAPSTSAEAK-PEDVRVEDDGSDSDSDGGMPGLEE--AVAATTQLGGGATGLPID--LVSKA 67
            ||...|..:..|| |.....:..|::||||..:|.|||  :..||||....|....||  .||||
Human  1866 KSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKA 1930

  Fly    68 KQSRGEKKARKIMLKLGLKQIQGVNRVTIRKSKNILFVINNPDVYKNPHSDTYIVFGEAKIEDLS 132
            ||||.||||||.|.||||:|:.||.||||||||||||||..|||||:|.||||||||||||||||
Human  1931 KQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLS 1995

  Fly   133 QQAQVAAAEKFKAPEAAGAADSVGATTSVAPIAEE-DEEDVDDTGVDEKDIELVITQANTTRAKA 196
            ||||:|||||||.  ...|..::...|....:.|| :||:||:|||:.||||||::|||.:||||
Human  1996 QQAQLAAAEKFKV--QGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKA 2058

  Fly   197 IKALKNNNNDIVNAIMELTM 216
            ::|||||:||||||||||||
Human  2059 VRALKNNSNDIVNAIMELTM 2078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nacalpha	NP_477216.1	NAC_NACA	84..131	CDD:409233	38/46 (83%)
		UBA_NAC_euk	179..215	CDD:270541	27/35 (77%)
NACA	NP_001352825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PHA03247	<2..395	CDD:223021
		PRK12323	<8..>184	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..96
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..614
		PHA03247	<720..1121	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..1944		36/77 (47%)
		PHA03247	<1273..1839	CDD:223021
		PXLXP. /evidence=ECO:0000250|UniProtKB:P70670	1841..1845
		Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:P70670	1932..1943		9/10 (90%)
		NAC_NACA	1947..1994	CDD:409233	38/46 (83%)
		UBA_NACA_NACP1	2032..2077	CDD:270598	33/44 (75%)