Protein Alignment GLS and glsb

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_693171.3
• Gene: glsb / 564746
• ZFINID: ZDB-GENE-030616-550
• Length: 635
• Species: Danio rerio
• Alignment Length: 644
• Identity: 305/644 - (47%)
• Similarity: 419/644 - (65%)
• Gaps: 31/644 - (4%)

  Fly    15 LLTTQAQVLVHQRAKASAAEPVEDFDQETDLLKRA---KFGHTGKQLQQKIINEKNLRAPPLMNL 76
            :|..:|.:::.:..:.|....:.|..:....|..|   ...:.|:..:..|::.......||
Zfish     1 MLQFRASIVLKELIQTSPKRLLSDIIRHKKTLPNAYCFSAANNGRISKLNIVHYGRCFIQPL--- 62

  Fly    77 VFANRKLSFYDTSS----TPKTKEDNAKLHREQEQR-------NAEDVLFDMFASEETGLISMGK 130
              |.|:.....|..    |...|:|........::|       :.||:||...| |....|...|
Zfish    63 --AGRRFLCTKTEGAIEPTETAKKDETVQEAAADKRRKAGILPSLEDLLFYSIA-EGQERIPAHK 124

  Fly   131 FLAGLKTTGIRRNDPRVRELMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFR 195
            |:..||.||:|..|||::|.||.||...|       |:::...|:|..||..|..||||:.:|||
Zfish   125 FITALKATGLRTGDPRLKECMDMLKVTLK-------STSDGVMLDRHLFKKCVQSNIVLLTQAFR 182

  Fly   196 QQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVP 260
            ::||||||.||...|:.:|.:.:..:.|.:||||||||:::||.|.:|:||:||||.::||..||
Zfish   183 KKFVIPDFQSFASHIDTLYEKGRNLSGGLVADYIPQLAKFSPDLWAVSLCTVDGQRHTVGDTKVP 247

  Fly   261 FTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMN 325
            |.||||.|||.|||::...|.:.||.::|:||||..||:|.||::.||||||:|||||:..||:.
Zfish   248 FCLQSCVKPLKYAISVHDHGTEYVHRFIGKEPSGLRFNKLFLDEDDKPHNPMVNAGAIVCTSLIK 312

  Fly   326 ALVKPDMTSAEIFDYTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRTNL 390
            .|.    .:||.|||.|::.|:::|.||:||:||.|.||||:.|||:|:|:|::|.||||..|::
Zfish   313 QLA----GNAEKFDYVMNFLKKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPDGTDM 373

  Fly   391 KEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSGQF 455
            ..|:|.|||.||:|..||:.||:||:|||||.||.|.|:|..||.:||.||:|||||.||:||||
Zfish   374 TAVLDLYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRDTLSLMHSCGMYDFSGQF 438

  Fly   456 AFKVGLPAKSGVSGGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKHLS 520
            ||.||||||||||||::||:||||||..||||||.|||:|||:|||.:|||:||||.||||:|.:
Zfish   439 AFHVGLPAKSGVSGGILLVVPNVMGIMCWSPPLDKLGNSVRGIQFCTDLVSLFNFHNYDNLRHFA 503

  Fly   521 NKKDPRKHRYETKGLSIVNLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLECV 585
            .|.|||:...:.:..|::||||:|.:|||:||||..||.:|:...|||.|||||:||:|||:|.|
Zfish   504 KKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSSVDMEQRDYDSRTALHVAAAEGHIEVV 568

  Fly   586 KFLLEQCHVPHNPKDRWGNLPVDEAENFGHCHVVEFLRSWAEKADQSSEECKPEAVTSK 644
            :||||.|.|...|||||||.|:|||::|||..|...|:.:..|.:.:......:..|.|
Zfish   569 RFLLEACKVNPAPKDRWGNTPMDEAKHFGHQEVQALLQEFNSKYNPTINPVADKETTEK 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	38/90 (42%)
		Glutaminase	223..511	CDD:461499	175/287 (61%)
		Ank_2	540..622	CDD:463710	50/81 (62%)
		ANK repeat	540..566	CDD:293786	14/25 (56%)
		ANK repeat	568..600	CDD:293786	20/31 (65%)
glsb	XP_693171.3	EF-hand_14	105..188	CDD:465587	38/90 (42%)
		Glutaminase	210..494	CDD:461499	175/287 (61%)
		ANKYR	<523..617	CDD:440430	52/93 (56%)
		ANK repeat	523..549	CDD:293786	14/25 (56%)
		ANK repeat	551..583	CDD:293786	20/31 (65%)