Protein Alignment GLS and gls2

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_002934555.2
• Gene: gls2 / 100492220
• XenbaseID: XB-GENE-985276
• Length: 592
• Species: Xenopus tropicalis
• Alignment Length: 557
• Identity: 276/557 - (49%)
• Similarity: 365/557 - (65%)
• Gaps: 28/557 - (5%)

  Fly    96 EDNAKLHREQEQRNAEDV-----------LFDMFASEETGLISMGKFLAGLKTTGIRRNDPRVRE 149
            :.|..:..|....|.|.:           |.....||....:.:.||:..||..||..:|||:::
 Frog    36 DHNIGMPGEAAPHNTEQITCNSVLQRLSNLLFYTVSEGQEQLPVYKFVNSLKANGILTSDPRLKD 100

  Fly   150 LMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFRQQFVIPDFTSFVKDIEDIY 214
            .||.|::.  :....||:.     ::||.|:..|..|||.:.:...::..||||..|...:..:|
 Frog   101 CMDMLQQT--VQELATGAV-----MDREMFQKCVQSNIVFLTQIVCKKLAIPDFEQFTLHVNRLY 158

  Fly   215 NRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVPFTLQSCSKPLTYAIALEKL 279
            ........|::|:||||||:.:|:.||:|:||:||||.||||..|||.||||.|||.|:||:..|
 Frog   159 ENASALDKGEVANYIPQLAKSSPERWGVSLCTVDGQRHSIGDTGVPFCLQSCVKPLKYSIAVNDL 223

  Fly   280 GPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMNALVKPDMTSAEIFDYTMSW 344
            |...||.::|:||||..||:|.|:...||||||:|||||:.||    |:||....||.|||.|..
 Frog   224 GTDFVHQHMGKEPSGNRFNKLSLNHEGKPHNPMVNAGAIVVCS----LIKPSTNKAEKFDYIMQS 284

  Fly   345 FKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRTNLKEVMDFYFQCCSMETNCEA 409
            .|.::|.|::||:||.|.||:|..|||||:|:||:|.||||...::...:|.|||.||:|..||:
 Frog   285 LKNMAGNEFVGFSNATFQSEKETGDRNYAIGYYMKEKKCFPSGIDMISALDLYFQLCSIEVTCES 349

  Fly   410 MSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLV 474
            .|||||:||||||||.|.::|...|.:|:.||:|||||.||:||||||.|||||||||||.::||
 Frog   350 GSVIAATLANGGICPITGQRVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVSGAILLV 414

  Fly   475 IPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKHLSNKKDPRKHRYETKGLSIVN 539
            :|||||:|.||||||.:||:|||:.||:||||:||||.||||:|...|.||||.|.|.:..::||
 Frog   415 VPNVMGVFCWSPPLDRIGNSVRGIHFCQELVSLFNFHNYDNLRHCVRKLDPRKERSEAQQKTVVN 479

  Fly   540 LLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLECVKFLLEQCHVPHNPKDRWGN 604
            |||:|.||||:||||..||.||:...|||.|||||:||:||||:.||||:|.|.|....:|||||
 Frog   480 LLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHLDVVKFLIEGCRVNPFAEDRWGN 544

  Fly   605 LPVDEAENFGHCHVVEFLRSWAE------KADQSSEE 635
            .|:.:|..|....||..|..:.|      :..:||||
 Frog   545 TPLQDAIRFERHDVVTLLSEYQEAYQKYLRGPESSEE 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	25/101 (25%)
		Glutaminase	223..511	CDD:461499	173/287 (60%)
		Ank_2	540..622	CDD:463710	47/81 (58%)
		ANK repeat	540..566	CDD:293786	16/25 (64%)
		ANK repeat	568..600	CDD:293786	19/31 (61%)
gls2	XP_002934555.2	EF-hand_14	62..145	CDD:465587	24/89 (27%)
		Glutaminase	167..451	CDD:461499	173/287 (60%)
		Ank_2	480..565	CDD:463710	48/84 (57%)
		ANK repeat	480..506	CDD:293786	16/25 (64%)
		ANK repeat	508..540	CDD:293786	19/31 (61%)