Protein Alignment GLS and gls

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_031748805.1
• Gene: gls / 100379734
• XenbaseID: XB-GENE-975800
• Length: 656
• Species: Xenopus tropicalis
• Alignment Length: 585
• Identity: 299/585 - (51%)
• Similarity: 403/585 - (68%)
• Gaps: 31/585 - (5%)

  Fly    82 KLSFYDTSSTPKTKEDNAKLHREQEQRNAEDVLFDMFASEETGLISMGKFLAGLKTTGIRRNDPR 146
            ||:..|..|..|...|..| :::....:.||:||...| |....|.:.||:..||.||:|.:|||
 Frog    82 KLTPPDVESASKPSSDEKK-NKQGLLPSLEDLLFYTIA-EGQEKIPVHKFITALKATGLRTSDPR 144

  Fly   147 VRELMDNLKKVHKLNNYETGSSAETQH----LNRETFKAVVAPNIVLIAKAFRQQFVIPDFTSFV 207
            ::|.||.|:           .|.:|..    |::|.||..|..||||:.:|||::||||||.||.
 Frog   145 LKECMDMLR-----------LSLQTMSDGVMLDKELFKKCVQSNIVLLTQAFRRKFVIPDFMSFT 198

  Fly   208 KDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVPFTLQSCSKPLTY 272
            ..|:::|...:..:.||:||||||||:::||.||:||||:||||.|:||..|||.||||.|||.|
 Frog   199 SHIDELYENARKLSGGKVADYIPQLAKFSPDLWGVSICTVDGQRHSVGDTKVPFCLQSCVKPLKY 263

  Fly   273 AIALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAIL---------TCSLMNALV 328
            |||:..|..:.||.|||:||||..||:|.|::::||||||:|||||:         |.:|||..:
 Frog   264 AIAVNDLSTEYVHRYVGKEPSGLRFNKLFLNEDEKPHNPMVNAGAIVITSLIKAFGTFALMNKTI 328

  Fly   329 -----KPDMTSAEIFDYTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRT 388
                 |...::||.|||.|.:|.:::|.||:||:||.|.||||:.|||:|:|:|::|.||||:.|
 Frog   329 ERGHRKQGSSNAEKFDYVMQFFNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEHT 393

  Fly   389 NLKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSG 453
            ::...:|||||.||:|..||:.||:||:|||||.||.|.|::..||.:|:.||:|||||.||:||
 Frog   394 DMVGTLDFYFQLCSIEVTCESASVMAATLANGGFCPITGERILSPEAVRNTLSLMHSCGMYDFSG 458

  Fly   454 QFAFKVGLPAKSGVSGGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKH 518
            ||||.||||:|||||||::||:|||||:..||||||.|||:|||:|||::|||:.|||.||||:|
 Frog   459 QFAFHVGLPSKSGVSGGILLVVPNVMGMMCWSPPLDKLGNSVRGIQFCQDLVSLCNFHNYDNLRH 523

  Fly   519 LSNKKDPRKHRYETKGLSIVNLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLE 583
            .:.|.|||:...:.:..|::||||:|.:|||:||||..|||||:...|||.|||||:|::|||:|
 Frog   524 FAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSGMDMEQRDYDSRTALHVASAEGHVE 588

  Fly   584 CVKFLLEQCHVPHNPKDRWGNLPVDEAENFGHCHVVEFLRSWAEKADQSSEECKPEAVTSKTQAD 648
            .|:||||.|.|...|||||.|.|:|||.:|||..||:.|:.:........|.......|.:|..|
 Frog   589 VVRFLLEACKVNPFPKDRWNNTPMDEAMHFGHHDVVKILQEYQNNYKPLDEPNNGNDQTVQTNLD 653

  Fly   649  648
             Frog   654  653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	37/94 (39%)
		Glutaminase	223..511	CDD:461499	178/301 (59%)
		Ank_2	540..622	CDD:463710	51/81 (63%)
		ANK repeat	540..566	CDD:293786	16/25 (64%)
		ANK repeat	568..600	CDD:293786	19/31 (61%)
gls	XP_031748805.1	EF-hand_14	109..192	CDD:465587	37/94 (39%)
		Glutaminase	214..516	CDD:461499	178/301 (59%)
		ANKYR	<545..>630	CDD:440430	52/84 (62%)
		ANK repeat	545..571	CDD:293786	16/25 (64%)
		ANK repeat	573..605	CDD:293786	19/31 (61%)