Protein Alignment GLS and gls2a

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_021327726.1
• Gene: gls2a / 100006303
• ZFINID: ZDB-GENE-081105-57
• Length: 614
• Species: Danio rerio
• Alignment Length: 588
• Identity: 286/588 - (48%)
• Similarity: 401/588 - (68%)
• Gaps: 34/588 - (5%)

  Fly    88 TSSTP---------KTKEDNAKLHREQEQRNAEDVLFDMFASEETGLISMGKFLAGLKTTGIRRN 143
            ||::|         ..:.|.|...||:.....||:||......|. .||:.:||..||:||::.:
Zfish    42 TSASPGQHPRQQHAVNETDAATYSREKVVSGLEDLLFYTITQGEE-KISVARFLTALKSTGLQTS 105

  Fly   144 DPRVRELMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFRQQFVIPDFTSFVK 208
            |||:|:.|   :::|    :....|..|..:::|.|:..|..||||:.:||:::|:||||.:|..
Zfish   106 DPRLRDCM---RQIH----HAVQDSVGTAMMDQELFRKCVGSNIVLLTQAFQRKFIIPDFEAFTS 163

  Fly   209 DIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVPFTLQSCSKPLTYA 273
            .|..:|...:|...||:|:||||||:::||.||:|:||:||||.::||.:|||.||||.|||.||
Zfish   164 LINHLYCDAQTQQGGKVANYIPQLAKFSPDLWGVSLCTVDGQRHAVGDTNVPFCLQSCVKPLEYA 228

  Fly   274 IALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMNALVKPDMTSAEIF 338
            :|:.:.|.:.||.|||:||||..||:|.||:.:||||||:|||||    ::::|:||....||.|
Zfish   229 LAVHETGSEHVHRYVGKEPSGLKFNKLSLDEEEKPHNPMVNAGAI----VISSLLKPGYNKAEKF 289

  Fly   339 DYTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRTNLKEVMDFYFQCCSM 403
            ||.:.:.||::|.||:||:||.|.||:|...||||:|:|::|.||||...::...:|||||.||:
Zfish   290 DYMVDYLKRMAGREYVGFSNATFQSEKETGYRNYAIGYYLKEKKCFPNGADMTAALDFYFQLCSI 354

  Fly   404 ETNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVS 468
            |..||:.||:||:||||||||.|.|:|...|.:|:.||:|||||.||:||||||.||||||||||
Zfish   355 EVTCESGSVMAATLANGGICPITGERVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVS 419

  Fly   469 GGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKHLSNKKDPRKHRYETK 533
            |.::||:||:||:..|||.||.:||::||:.||:||||:||||.||||:|.:.|.|||:.....:
Zfish   420 GAVLLVVPNIMGVMCWSPALDRVGNSIRGIHFCQELVSLFNFHNYDNLRHFAKKLDPRRQTGHER 484

  Fly   534 GLSIVNLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLECVKFLLEQCHVPHNP 598
            ..|:|:|:|:|.||||:||||..||.:::.|.|||.|||||:|::|||||.||||.:.|.|....
Zfish   485 NKSVVDLMFAAYSGDVSALRRIALSAVNMELTDYDSRTALHVASAEGHLEAVKFLTDTCKVNPYV 549

  Fly   599 KDRWGNLPVDEAENFGHCHVVEFLRSWAEKADQS--SEECKPEAVTSKT------QADEVSSSSN 655
            ||||||.|:|:|..|||..|.:.|:.:     ||  :....||.:::.|      .|||:.|...
Zfish   550 KDRWGNTPLDDAMQFGHNTVAKVLQEY-----QSIYTHTLLPEVLSADTCPDSSIDADELKSMET 609

  Fly   656 SSS 658
            ..|
Zfish   610 LES 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	31/90 (34%)
		Glutaminase	223..511	CDD:461499	169/287 (59%)
		Ank_2	540..622	CDD:463710	47/81 (58%)
		ANK repeat	540..566	CDD:293786	14/25 (56%)
		ANK repeat	568..600	CDD:293786	18/31 (58%)
gls2a	XP_021327726.1	EF-hand_14	73..156	CDD:465587	31/90 (34%)
		Glutaminase	178..462	CDD:461499	169/287 (59%)
		Ank_2	491..576	CDD:463710	48/84 (57%)
		ANK repeat	491..517	CDD:293786	14/25 (56%)
		ANK repeat	519..551	CDD:293786	18/31 (58%)