Protein Alignment Sin3A and sin3b

DIOPT Version :10

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_001072289.1
• Gene: sin3b / 779742
• XenbaseID: XB-GENE-480338
• Length: 1126
• Species: Xenopus tropicalis
• Alignment Length: 1735
• Identity: 524/1735 - (30%)
• Similarity: 728/1735 - (41%)
• Gaps: 654/1735 - (37%)

  Fly   261 GQSGNATPR-----------LKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVI 314
            |..||..|.           :.||||||||||||.::...|..|:.||:|||||||..|||||||
 Frog     5 GGGGNCKPNSNWSKPQEKLPVHVEDALSYLDQVKIRFGSDPATYSGFLEIMKEFKSQSIDTPGVI 69

  Fly   315 ERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSM 379
            .|||.||..|.:|:.|||.|||.|||||:..:  |..|...|:.||..:..:|         ||:
 Frog    70 RRVSQLFHEHPDLMLGFNAFLPLGYKIELPKN--GKVVVQTSLASPVSSDATT---------SSL 123

  Fly   380 SGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQ 444
            |
 Frog   124 S---------------------------------------------------------------- 124

  Fly   445 SQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNAS 509
                             ::..:||..|...:|  .||:. ||.:|:....|
 Frog   125 -----------------SSRVIVPPVPENVLS--EVPEE-SRQQEKEKPQP-------------- 155

  Fly   510 ASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAIT 574
                   ||..:||                                            ||::||:
 Frog   156 -------PPESDSL--------------------------------------------EFHNAIS 169

  Fly   575 YVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLR 639
            ||||||.||.::|..|:.||||||.||::| :..:|...:|  ::|:||:|:||.||...||||.
 Frog   170 YVNKIKTRFLDRPEIYRSFLEILHTYQKDQ-LNPKGRPFRG--MSEEEVFTEVASLFRGQEDLLS 231

  Fly   640 EFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQ 704
            |||||||:|                    ||...|.:|...::
 Frog   232 EFGQFLPEA--------------------KRSLFTGNGACDLS---------------------- 254

  Fly   705 IDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRG 769
                                                                             
 Frog   255 ----------------------------------------------------------------- 254

  Fly   770 AGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSY 834
                                                             ::.|.:..|.::|...
 Frog   255 -------------------------------------------------SRKLEYQRNLEQSRKR 270

  Fly   835 GIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAK 899
            ..|.::.|||........|.|...|.|:                         ||.|.
 Frog   271 SRPLLLRSMPSSKKKMKMRKSKDQSMAS-------------------------VGKYG------- 303

  Fly   900 RPKPYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSP 964
                              |:.:.:||:|||:.|:|.|||:|||||:.|||||:||.:|||.||:|
 Frog   304 ------------------TLQEFSFFNKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVTP 350

  Fly   965 FLMKFPDLLRWFTDFLGPPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVD 1029
            ||.|||:|...|..|||                   .::...:|..::||  |::...   :::|
 Frog   351 FLGKFPELFAQFKSFLG-------------------VKELSFASPVTNDR--SNEGIG---REID 391

  Fly  1030 LSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYR 1094
            .:||||:|:||.|||:|....|||||||||:|||||.|||||:| |||||||:|:||.:||
 Frog   392 YASCKRIGSSYRALPKSFPHPKCSGRTALCKEVLNDTWVSFPSW-SEDSTFVSSKKTPYEE---- 451

  Fly  1095 NIHRTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRI 1159
            .:||.||||||||:|:|.|.|||||||::|||:||||.|:..||.|||.|||||:.|.:|||:||
 Frog   452 QLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMSPEDQEKFRLDDRLGGTSEVIQRRAIYRI 516

  Fly  1160 YGDKSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFK 1224
            ||||:.:|:..:||||..|||:||||||.|||||||||:.|||.||||.|:.|||||||||:|||
 Frog   517 YGDKAPDIVESLKKNPVTAVPVVLKRLKAKEEEWREAQRGFNKIWREQYERAYLKSLDHQAVNFK 581

  Fly  1225 PNDMKALRSKSLFNEIETLYDERHDQEDD--AMEPFGPHLVLPYKDKTILDDAANLLIHHVKRQT 1287
            .||.||||||||.||||::||||.:|:.|  .....||||:..|:|..||:|||.|:..:|.||.
 Frog   582 QNDTKALRSKSLLNEIESVYDERQEQQPDGRTTTSSGPHLIYTYEDWQILEDAAALITFYVNRQP 646

  Fly  1288 GIQKQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAK 1352
            .|||::|..|.|::.||:|:|||:
 Frog   647 TIQKEDKDTIWQVLHQFLPELFFS----------------------------------------- 670

  Fly  1353 STPSESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAA 1417
               |.|:||:                                               ..|..||:
 Frog   671 ---SSSSSPS-----------------------------------------------CQSLFAAS 685

  Fly  1418 ASAASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSN 1482
            |....:.||                      |.|.|...|.:.:.|    |..|:..|.|.....
 Frog   686 ADEGPTETV----------------------TESSVTELPERRRKT----VTTEVAQEPPPPVET 724

  Fly  1483 PKLLPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIE-------EERC- 1539
            |...||    :..||.|:||:.|||||.|||||..||.||..:|.:|:...:|       |:|.
 Frog   725 PHEPPP----KTIDEVYSLFYTNNNWYFFLRLHHTLCSRLLKIYRQAQQQLMEYRTEKEREKRLF 785

  Fly  1540 --RVNRRESTATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFT 1602
              |.:|....|..||||...|:::|:|||.||||::|:..||:|...:|||:||||.|:|||.||
 Frog   786 DGRRDRSNGPAMELRLKQPSEVELEEYYPAFLDMVRNLFIGNLDPTHYEDTLREMFTIHAYIVFT 850

  Fly  1603 LDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEE 1667
            :||:|.|..|||.:.|::...|..|||:.:|::||..||..........:|.|||.|||..:.:|
 Frog   851 IDKLVQNITRQLHHLVSDEICLKVVELYLSEKKRGAAGGSLASQCVRAAKEASYQWKAEHCMTDE 915

  Fly  1668 NCFKVYIYKIDCRV--TIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALG 1730
            ||||:...:...:|  ||||||:|..:.:.|.  :.|..:.|:|:..|
 Frog   916 NCFKMMFLQRQGQVTMTIELLDTEDVQTEDPT--EVQHLANYMEQFIN----------------- 961

  Fly  1731 NDSVVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLEEQVRQL--FEHRRNRIE 1793
                |||           |.....||         |::    :..||:..:|..  :::|..|:.
 Frog   962 ----VDG-----------AHSSQSEG---------FVL----KPVLLQRNIRSFHSWQYRTMRVM 998

  Fly  1794 QHGTAASLEPI-SVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLGAPQVGLAEQYAF 1857
            :....:|.:.: .|:||.:.:.                                       ::..
 Frog   999 KDEVKSSWKKLMGVESASNMDC---------------------------------------RFRL 1024

  Fly  1858 NDRDEISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQ 1922
            |         |:...|:.:....:.::..:..|::...:|.|..:..|..:.|:||:::||.:..
 Frog  1025 N---------SHKMMFIINSEDYMYRWGTLSGAREVQPQVFQRHHEKFSEWHNRWLEENVSPRAA 1080

  Fly  1923 QNCVDWLLGKTADQINASGWGSASKTKTVQQKD----TSKTPYRI 1963
            |...|||.|:..:::        ...|||.:..    .|.|.||:
 Frog  1081 QVIQDWLTGEEDEEM--------VPCKTVCENSEVHGMSVTRYRV 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	484/1482 (33%)
sin3b	NP_001072289.1	Sin3	19..1072	CDD:227889	505/1666 (30%)