Protein Alignment Sin3A and Sin3b

DIOPT Version :10

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: NP_001401963.1
• Gene: Sin3b / 683381
• RGDID: 1587989
• Length: 1095
• Species: Rattus norvegicus
• Alignment Length: 1732
• Identity: 524/1732 - (30%)
• Similarity: 707/1732 - (40%)
• Gaps: 690/1732 - (39%)

  Fly   261 GQSGNATPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHT 325
            |..|:....:.|||||:||||||.::...|..||.||:|||||||..|||||||.|||.||..|.
  Rat    23 GSGGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHP 87

  Fly   326 ELIYGFNMFLPPGYKIEIHSDALGCSVPVVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTT 390
            :||.|||.|||.||:|:|
  Rat    88 DLIVGFNAFLPLGYRIDI----------------------------------------------- 105

  Fly   391 NAATLTPAAGAGAAAAAAAVAQIQSAGAVNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHV 455
                                                                     |..|.:::
  Rat   106 ---------------------------------------------------------PKNGKLNI 113

  Fly   456 SVTNSTAANAVVPGQPGISVSAHNVPQNYSRDRERATITPTGQVAGAAANVNASASIVVGGPPTP 520
            ....|...|:...|..|....    ..:|..||
  Rat   114 QSPLSNQDNSHSHGDCGEDFK----QMSYKEDR-------------------------------- 142

  Fly   521 NSLSELSPHGGAGGGPGAGAAQHNLHHIQQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQN 585
                                                 |:...::..||||:||:||||||.||.:
  Rat   143 -------------------------------------GQVPLESDSVEFNNAISYVNKIKTRFLD 170

  Fly   586 QPAKYKKFLEILHDYQREQKVMKEGSLNQGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATN 650
            .|..|:.||||||.||:|| :..:|...:|  ::|:||:|:||.||...||||.|||||||:|
  Rat   171 HPEIYRSFLEILHTYQKEQ-LHTKGRPFRG--MSEEEVFTEVANLFRGQEDLLSEFGQFLPEA-- 230

  Fly   651 HQSGQYMSKSASVHNDHGKRPTATLSGGAHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIG 715
                              ||...|.:|...:
  Rat   231 ------------------KRSLFTGNGSCEM---------------------------------- 243

  Fly   716 NLSAVNTSVSIKTYNNNQQQQNHVIGSGLNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAG 780
                            |..|:|.               ||..
  Rat   244 ----------------NSAQKNE---------------EKSL----------------------- 254

  Fly   781 TAAGANIGRPGVGASVMVSYDKEHRNNHHVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPH 845
                                  ||:.
  Rat   255 ----------------------EHKK--------------------------------------- 258

  Fly   846 ISDNSLDRSSPGISYATPPLPSGPHGQHNSGSATRRPGDDSLVGHYASGAPPAKRPK-PYCRDVS 909
                   ||.|.:                     .||          ..||..|:.| ...:|:|
  Rat   259 -------RSRPSL---------------------LRP----------VSAPAKKKMKLRGTKDLS 285

  Fly   910 FSEASSKCTISDAAFFDKVRKALRSPEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLR 974
            .:......|:.:.:||||||:.|:|.|||:|||||:.|||||:||.:|||.||||||.|||:|..
  Rat   286 IAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA 350

  Fly   975 WFTDFLG-------PPSGQPAGGLIDGMPLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSS 1032
            .|..|||       ||               .:.|.|.|.|                 :::|.:|
  Rat   351 QFKSFLGVKELSFAPP---------------MSDRSGDGIS-----------------REIDYAS 383

  Fly  1033 CKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIH 1097
            |||:|:||.|||::....|||||||:|:|||||.|||||:| |||||||:|:||.:||    .:|
  Rat   384 CKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSW-SEDSTFVSSKKTPYEE----QLH 443

  Fly  1098 RTEDERFELDLVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGD 1162
            |.||||||||:|:|.|.|||||||::|||:|||:.|:..|..|||.|||||:.|.:|||||||||
  Rat   444 RCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYGD 508

  Fly  1163 KSGEIITGMKKNPFVAVPIVLKRLKVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPND 1227
            |:.|:|..:|:||..|||:||||||.|||||||||:.|||.||||.||.|||||||||:|||.||
  Rat   509 KAPEVIESLKRNPATAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQND 573

  Fly  1228 MKALRSKSLFNEIETLYDERHDQEDDAME-PFG-PHLVLPYKDKTILDDAANLLIHHVKRQTGIQ 1290
            .||||||||.||||::|||..:|..:... |.. |||:..|:|:.||:|||.|:.::||||..||
  Rat   574 TKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQ 638

  Fly  1291 KQEKQKIKQIIRQFVPDLFFAPRQPLSDDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTP 1355
            |:::..|:|::.:|:|.|||:.::|.:.|:                             :|....
  Rat   639 KEDQGTIRQLLHRFLPSLFFSQQRPATSDD-----------------------------SADERD 674

  Fly  1356 SESASPARSNASTSSVTPAGIKKETDDSKATTGSFAPASSATASSATPVDDATPSTSSAAAAASA 1420
            .:||.|.|             ::.||:.                   |..||||
  Rat   675 RDSAEPER-------------RRPTDEK-------------------PPTDATP----------- 696

  Fly  1421 ASSSTVSGTEGKPKDDPLSSHKEEGAGSTSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKL 1485
                           :|                                             ||.
  Rat   697 ---------------EP---------------------------------------------PKA 701

  Fly  1486 LPPHAHGQREDESYTLFFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEER--------CRVN 1542
            |         |:.|:|||||||||.|||||..||.||..:|.:|:...:|..|        |...
  Rat   702 L---------DDVYSLFFANNNWYFFLRLHQTLCARLLKIYRQAQKQLLEHRREQEREQLLCEGR 757

  Fly  1543 RREST--ATALRLKPKPEIQVEDYYPTFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDK 1605
            |.::|  |..||||...|:::|:|||.||||::::|:|::|...:|||:||||.|:|||.||:||
  Rat   758 REKATDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYIGFTMDK 822

  Fly  1606 VVSNAVRQLQYCVTERAALDCVELFATEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCF 1670
            :|.|..|||.:.|::...|..|||:..||:||..||..........||.|||.|||..:.:||||
  Rat   823 LVQNIARQLHHLVSDDVCLKVVELYLNEQQRGAAGGNLSSRCVRAARETSYQWKAERCMADENCF 887

  Fly  1671 KVYIYKIDCRV--TIELLDSEPEEVDKPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDS 1733
            ||...:...:|  ||||||:|..:.:.|  ::.|..::|||:..       |..|.|:|
  Rat   888 KVMFLQRRGQVIMTIELLDTEEAQAEDP--VEVQHLARYVEQYV-------GTEGASNS------ 937

  Fly  1734 VVDGSDIKTEADEDTAELRYREGGIGGAGKARFLVRNKRRSKLLE-EQVRQLFEHRRNRIEQHGT 1797
                   .||               |...|..||.||.::.:..: ||||.:          .|.
  Rat   938 -------PTE---------------GFLLKPVFLQRNLKKFQRWQCEQVRAM----------RGE 970

  Fly  1798 AASLEPISVDSAISSNSTTGGGGSGTNNNNNNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDE 1862
            |.|                                  ||  |||       :|:......:.|..
  Rat   971 AKS----------------------------------SW--KRL-------MGVESACDVDCRFR 992

  Fly  1863 ISTNISNGRCFVTSKNLKLLKYDAVRRAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQNCVD 1927
            :.|   :...|:.:....:.:...:.|||:....|....:.||:.:..:||:.:||........|
  Rat   993 LGT---HKMVFIVNSEDYMYRRGTLCRAKQVQPLVLLRHHRHFEEWHGRWLEDNVSVAAAGLVQD 1054

  Fly  1928 WLLGKTADQINASGWGSASKT--KTVQQKDTSKTPYRI-YNR 1966
            ||:|:..:.:      ...||  :|........|.||: |:|
  Rat  1055 WLMGEEEEDM------VPCKTLCETAHVHGLPVTRYRVQYSR 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	474/1479 (32%)
Sin3b	NP_001401963.1	Sin3	31..1006	CDD:227889	500/1632 (31%)