Protein Alignment Sin3A and Sin3b

DIOPT Version :10

• Sequence 1: NP_001246282.1
• Gene: Sin3A / 36382
• FlyBaseID: FBgn0022764
• Length: 2066
• Species: Drosophila melanogaster
• Sequence 2: XP_006530852.1
• Gene: Sin3b / 20467
• MGIID: 107158
• Length: 1119
• Species: Mus musculus
• Alignment Length: 1771
• Identity: 537/1771 - (30%)
• Similarity: 724/1771 - (40%)
• Gaps: 710/1771 - (40%)

  Fly   242 PPSSVVANSIPVGGTTP-----------PQGQSGNATPRL-------KVEDALSYLDQVKYQYAD 288
            ||...:..:.| |..||           |:....|:.|.|       :|||||:||||||.::..
Mouse     8 PPWPPLCAAGP-GDPTPLPRNPSVFAAAPRFPPNNSFPPLLGLLRDTEVEDALTYLDQVKIRFGS 71

  Fly   289 QPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVP 353
            .|..||.||:|||||||..|||||||.|||.||..|.:||.|||.|||.||:|:|..:
Mouse    72 DPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKN------- 129

  Fly   354 VVSMPSPPGAPTSTGTVHMLTGNSSMSGAGHIAIKTTNAATLTPAAGAGAAAAAAAVAQIQSAGA 418
                                                                           |.
Mouse   130 ---------------------------------------------------------------GK 131

  Fly   419 VNLMTHGGASLTQTTIHALQQATPPQSQSPGGGHVHVSVTNSTAANAVVPGQPGISVSAHNVPQN 483
            :|:.                  :|..||.  ..|.|              |..|....    ..:
Mouse   132 LNIQ------------------SPLSSQD--NSHSH--------------GDCGEDFK----QMS 158

  Fly   484 YSRDRERATITPTGQVAGAAANVNASASIVVGGPPTPNSLSELSPHGGAGGGPGAGAAQHNLHHI 548
            |..||
Mouse   159 YKEDR------------------------------------------------------------ 163

  Fly   549 QQAHQSILLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMKEGSLN 613
                     |:...::..||||:||:||||||.||.:.|..|:.||||||.||:|| :..:|...
Mouse   164 ---------GQVPLESDSVEFNNAISYVNKIKTRFLDHPEIYRSFLEILHTYQKEQ-LHTKGRPF 218

  Fly   614 QGKMLTEQEVYTQVAKLFGQDEDLLREFGQFLPDATNHQSGQYMSKSASVHNDHGKRPTATLSGG 678
            :|  ::|:||:|:||.||...||||.|||||||:|                    ||...|.:|.
Mouse   219 RG--MSEEEVFTEVANLFRGQEDLLSEFGQFLPEA--------------------KRSLFTGNGS 261

  Fly   679 AHITMSSASPAPSGSPLHLGATTLPQIDKSAHAAAIGNLSAVNTSVSIKTYNNNQQQQNHVIGSG 743
            ..:                                                  |..|:|.
Mouse   262 CEM--------------------------------------------------NSGQKNE----- 271

  Fly   744 LNATRNDILFEKDYHAGLQQQAHQRGAGVGGHHHLAGTAAGANIGRPGVGASVMVSYDKEHRNNH 808
                      ||...
Mouse   272 ----------EKSLE-------------------------------------------------- 276

  Fly   809 HVQKYVGHAPNQNLTHGHNAKKSPSYGIPSVIGSMPHISDNSLDRSSPGISYATPPLPSGPHGQH 873
                             ||.|:|.    ||::
Mouse   277 -----------------HNKKRSR----PSLL--------------------------------- 287

  Fly   874 NSGSATRRPGDDSLVGHYASGAPPAKRPK-PYCRDVSFSEASSKCTISDAAFFDKVRKALRSPEV 937
                   ||          ..||..|:.| ...:|:|.:......|:.:.:||||||:.|:|.||
Mouse   288 -------RP----------VSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEV 335

  Fly   938 YDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLG-------PPSGQPAGGLIDGM 995
            |:|||||:.|||||:||.:|||.||||||.|||:|...|..|||       ||
Mouse   336 YENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFAQFKSFLGVKELSFAPP------------ 388

  Fly   996 PLAATQRQGGGSSNSSHDRGTSHQSAAEYVQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCR 1060
               .:.|.|.|.|                 :::|.:||||:|:||.|||::....|||||||:|:
Mouse   389 ---MSDRSGDGIS-----------------REIDYASCKRIGSSYRALPKTYQQPKCSGRTAICK 433

  Fly  1061 EVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRNIHRTEDERFELDLVIEVNSATIRVLENLQK 1125
            |||||.|||||:| |||||||:|:||.:||    .:||.||||||||:|:|.|.|||||||::||
Mouse   434 EVLNDTWVSFPSW-SEDSTFVSSKKTPYEE----QLHRCEDERFELDVVLETNLATIRVLESVQK 493

  Fly  1126 KMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSGEIITGMKKNPFVAVPIVLKRLKVKE 1190
            |:|||:.|:..|..|||.|||||:.|.:||||||||||:.|:|..:|:||..|||:||||||.||
Mouse   494 KLSRMAPEDQEKLRLDDCLGGTSEVIQRRAIHRIYGDKAPEVIESLKRNPATAVPVVLKRLKAKE 558

  Fly  1191 EEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAM 1255
            |||||||:.|||.||||.||.|||||||||:|||.||.||||||||.||||::|||..:|..:..
Mouse   559 EEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGR 623

  Fly  1256 E-PFG-PHLVLPYKDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLFFAPRQP-LS 1317
            . |.. |||:..|:|:.||:|||.|:.::||||..|||:::..|:|::.:|:|.|||:.:.| .|
Mouse   624 SAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIRQLLHRFLPSLFFSQQCPGTS 688

  Fly  1318 DDERDDAFPFLVDDNTKMDVDSPLGRTESSTRNAKSTPSESASPARSNASTSSVTPAGIKKETDD 1382
            ||..|:                            :....:||.|.|             ::.||:
Mouse   689 DDSADE----------------------------RDRDRDSAEPER-------------RRPTDE 712

  Fly  1383 SKATTGSFAPASSATASSATPVDDATPSTSSAAAAASAASSSTVSGTEGKPKDDPLSSHKEEGAG 1447
            .                   |..||:|                          :|
Mouse   713 K-------------------PPADASP--------------------------EP---------- 722

  Fly  1448 STSSGVATSPRQAQDTAGAGVDVEIKLEHPADFSNPKLLPPHAHGQREDESYTLFFANNNWYLFL 1512
                                               ||:|         |:.|:|||||||||.||
Mouse   723 -----------------------------------PKVL---------DDVYSLFFANNNWYFFL 743

  Fly  1513 RLHAILCDRLHVMYERARLLAIEEER--------CRVNRREST---ATALRLKPKPEIQVEDYYP 1566
            |||..||.||..:|.:|:...:|..|        |. .|||..   |..||||...|:::|:|||
Mouse   744 RLHQTLCARLLKIYRQAQKQLLEHRREQEREQLLCE-GRREKAADPAMELRLKQPSEVELEEYYP 807

  Fly  1567 TFLDMLKNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFA 1631
            .||||::::|:|::|...:|||:||||.|:|||.||:||:|.|..|||.:.|::...|..|||:.
Mouse   808 AFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYIGFTMDKLVQNIARQLHHLVSDDVCLKVVELYL 872

  Fly  1632 TEQRRGCTGGFCRDAHKTFDREMSYQRKAESILNEENCFKVYIYKIDCRV--TIELLDSEPEEVD 1694
            .||:||..||..........||.|||.|||..:.:||||||...:...:|  ||||||:|..:.:
Mouse   873 NEQQRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRRGQVIMTIELLDTEEAQTE 937

  Fly  1695 KPAALKAQKFSKYVERLANPALGGGGNTGRSDSALGNDSVVDGSDIKTEADEDTAELRYREGGIG 1759
            .|  ::.|..::|||:..       |:.|.|.|:             ||               |
Mouse   938 DP--VEVQHLARYVEQYV-------GSEGASSSS-------------TE---------------G 965

  Fly  1760 GAGKARFLVRNKRRSKLLE-EQVRQLFEHRRNRIEQHGTAASLEPISVDSAISSNSTTGGGGSGT 1823
            ...|..||.||.::.:..: ||||.:          .|.|.|
Mouse   966 FLLKPVFLQRNLKKFRRWQCEQVRAM----------RGEAKS----------------------- 997

  Fly  1824 NNNNNNNNNNNSWGGKRLERLGAPQVGLAEQYAFNDRDEISTNISNGRCFVTSKNLKLLKYDAVR 1888
                       ||  |||       :|:......:.|..:.|   :...|:.:....:.:...:.
Mouse   998 -----------SW--KRL-------MGVESACDVDCRFRLGT---HKMVFIVNSEDYMYRRGTLC 1039

  Fly  1889 RAKKSHCRVTQAKYAHFQTYVNKWLQQHVSEQQQQNCVDWLLGKTADQINASGWGSASKT--KTV 1951
            |||:....|....:.||:.:..:||:.:|:........|||:|:..:.:      ...||  :|.
Mouse  1040 RAKQVQPLVLLRHHRHFEEWHGRWLEDNVTVAAAGLVQDWLMGEEEEDM------VPCKTLCETA 1098

  Fly  1952 QQKDTSKTPYRI-YNR 1966
            .......|.||: |:|
Mouse  1099 HVHGLPVTRYRVQYSR 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sin3A	NP_001246282.1	Sin3	238..1719	CDD:227889	488/1518 (32%)
Sin3b	XP_006530852.1	Sin3	40..1030	CDD:227889	509/1646 (31%)