Protein Alignment ClC-b and Clcn3

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_038950796.1
• Gene: Clcn3 / 84360
• RGDID: 621219
• Length: 866
• Species: Rattus norvegicus
• Alignment Length: 869
• Identity: 242/869 - (27%)
• Similarity: 389/869 - (44%)
• Gaps: 191/869 - (21%)

  Fly    47 TSALARRATLSGNNHLLD----DSQPLLMGNNSVPPDIPI-NGSAGSPNRNINSS--------EP 98
            |||.:....|.|...::|    :...||.|:.:......: ||.      :||||        ||
  Rat    20 TSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGG------SINSSTHLLDLLDEP 78

  Fly    99 IFHLRSRTAAASTPNYESLDY--EVCENTLFQDEQRKRLTER-----FSLRKDII----RWIIFI 152
            |      ....:..::.::|:  |.|::.    |:.:|:..:     :.:.|.:.    .|::..
  Rat    79 I------PGVGTYDDFHTIDWVREKCKDR----ERHRRINSKKKESAWEMTKSLYDAWSGWLVVT 133

  Fly   153 QIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLS----------------DASDRDL--- 198
            ..|:.:..:|..|||..:.::         .:||.:.||                ...:||.
  Rat   134 LTGLASGALAGLIDIAADWMT---------DLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQ 189

  Fly   199 ---------------------LIPYLYWLL-FSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNG 241
                                 .|.|::|.| |:.:.|    ::|....|...|||||::|:.|:|
  Rat   190 WKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAV----SLVKVFAPYACGSGIPEIKTILSG 250

  Fly   242 VKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFR 306
            ..|...:...||.:|.|.::.:|..||:.|||||::|.....      |...::|    ..|...
  Rat   251 FIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCC------GNIFSYL----FPKYST 305

  Fly   307 DDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAY 371
            ::.:||:.:....|||||.||||||||:||||||.:.::....:||:..|::::.|.|
  Rat   306 NEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVL------- 363

  Fly   372 HGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWK 434
            ..:|.|  :...||.: ::.||  :..|||..|::|||.|||.||.:...|....:.||   ..|
  Rat   364 RSINPFGNSRLVLFYV-EYHTP--WYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRK---STK 422

  Fly   435 IGK--VLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCE-DNEYNA 485
            .||  |||.::||.:...:|.           |:.....||.||.:..       .|: .|:.||
  Rat   423 FGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSS-------LCDYRNDMNA 480

  Fly   486 VAALWFQTPEATVRSLFHDPPG---SHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAA 547
                     ...|..:...|.|   ...|..|.|..:...:::..|||:.|..|:|||:..:||.
  Rat   481 ---------SKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAI 536

  Fly   548 WGRLLAM----LTYY-----VFPQ-----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETT 598
            .||::.:    |.||     :|.:     |:.:.||.||::||||.||||.|||:||.||:.|.|
  Rat   537 AGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELT 601

  Fly   599 GVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKA---REILSKP 659
            | ...:..||:.|::::|||||.| .||||:..|::|..|.|..:....:..|.|   |...|.|
  Rat   602 G-GLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDP 665

  Fly   660 VICIKIRD--SANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENK 722
            .:.:..:|  :.:.|..|:.:..:|||||:..     :...|:.|..||..|.:.:..:   ..|
  Rat   666 PLAVLTQDNMTVDDIENMINETSYNGFPVIMS-----KESQRLVGFALRRDLTIAIESA---RKK 722

  Fly   723 RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRAL 787
            :..:..:|...|....|..|: :|.|.|  |:...:|:      ||..|..|..:..:..|||.|
  Rat   723 QEGVVGSSRVCFAQHTPSLPA-ESPRPL--KLRSILDM------SPFTVTDHTPMEIVVDIFRKL 778

  Fly   788 GLRHLLVINHENRIAGIITRRDFI 811
            |||..|| .|...:.||||:::.:
  Rat   779 GLRQCLV-THNGIVLGIITKKNIL 801

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	177/609 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	45/165 (27%)
		CBS repeat	657..763	CDD:341367	25/107 (23%)
		CBS repeat	769..812	CDD:341367	16/43 (37%)
Clcn3	XP_038950796.1	ClC_3_like	136..642	CDD:239656	170/558 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	653..803	CDD:341367	46/167 (28%)
		CBS repeat	659..754	CDD:341367	25/105 (24%)
		CBS repeat	760..802	CDD:341367	16/43 (37%)