Protein Alignment ClC-b and CLC-F

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_564698.1
• Gene: CLC-F / 842011
• AraportID: AT1G55620
• Length: 781
• Species: Arabidopsis thaliana
• Alignment Length: 807
• Identity: 165/807 - (20%)
• Similarity: 269/807 - (33%)
• Gaps: 282/807 - (34%)

  Fly     2 DDRKALITLDGES----------SAEDDPIILQKEAGPTSKAVQDFGLH---------------- 40
            :||..|.:.||:.          ..|.....::..||    .|:|...|
plant    11 EDRHLLRSTDGDEVGIGGGEGDLDVESQSPAIRSGAG----GVRDLFKHIDRRFSLSGRRLSFKR 71

  Fly    41 --------QREEP-STSALARRATLSG----NNHLLDD-------SQPLLMGNNSVPPD------ 79
                    :|..| |:||.:......|    |.|.:||       .:.:|  .:|.||:
plant    72 MENIRVDRERHNPSSSSAFSAAGEEDGGGISNLHSVDDRNDEYGFDEEVL--GDSAPPEWALLLI 134

  Fly    80 -IPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRK 143
             ..|..:||......|....:.|   ..|.|.|||         |...:...||...|
plant   135 GCLIGVAAGICVAGFNKGVHVIH---EWAWAGTPN---------EGAAWLRLQRLADT------- 180

  Fly   144 DIIRW--IIFIQI--GIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLY 204
                |  |:.|.:  |:|..::...::|:                 :.:..|::|.|.
plant   181 ----WHRILLIPVTGGVIVGMMHGLLEIL-----------------DQIRQSNSSQRQ------- 217

  Fly   205 WLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLA 269
                       |...:..|.|:                            :|||....::..|.:
plant   218 -----------GLDFLAGIYPV----------------------------IKAIQAAVTLGTGCS 243

  Fly   270 GGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL--GGGAAGVSAAFGAPIG 332
            .|.|||.:..|...|.|               |....:::.:|...|  .|.|:|:::.|.|.:.
plant   244 LGPEGPSVDIGKSCANG---------------FALMMENNRERRIALTAAGAASGIASGFNAAVA 293

  Fly   333 GMLFSLE--------EAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFD 389
            |..|::|        |.:..:...:|   ::||:||....|.:|..         ...|.:..:|
plant   294 GCFFAIETVLRPLRAENSPPFTTAMI---ILASVISSTVSNALLGT---------QSAFTVPSYD 346

  Fly   390 TPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVAMMGVTLACL 454
              || ...|||:::|||:..|.:...::.|.|...| ...||..|.|  |.|:|...:|...|.:
plant   347 --LK-SAAELPLYLILGMLCGAVSVVFSRLVTWFTK-SFDFIKDKFG--LPAIVCPALGGLGAGI 405

  Fly   455 MIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFH-----DPPGSHKILTL 514
            :..                        :|..:....|    ..|..:.|     ..||...:..|
plant   406 IAL------------------------KYPGILYWGF----TNVEEILHTGKSASAPGIWLLAQL 442

  Fly   515 ALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL----AMLTYYVFP-QAEFLHPGKYALI 574
            |...||...| |...|| |. |::.|:.::|||.|.:.    |.:.....| .|....|..|||:
plant   443 AAAKVVATAL-CKGSGL-VG-GLYAPSLMIGAAVGAVFGGSAAEIINRAIPGNAAVAQPQAYALV 504

  Fly   575 GAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFN---------------- 623
            |.||.|..:..:.::..::|.|.| .:.....||:.|:..|.||....|
plant   505 GMAATLASMCSVPLTSVLLLFELT-KDYRILLPLMGAVGLAIWVPSVANQGKESDSSEGRSTGRG 568

  Fly   624 -----------EGIY-------DTQIQV----NHVPMLTWEPLPQYKGLKAREILSKPVICIK-- 664
                       ||::       ..::.|    :|...|..|.:  .:.||...::||..:.:.
plant   569 YSSLSPSERKTEGVWRHTDNADSLELTVIENPDHNSFLDEETI--LEDLKVMRVMSKNYVKVSSG 631

  Fly   665 --IRDSANYIYEMLKKCDHNGFPVVDD 689
              :|::.|    :||:...|...||||
plant   632 TTLREARN----ILKESHQNCIMVVDD 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	115/585 (20%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	11/42 (26%)
		CBS repeat	657..763	CDD:341367	11/37 (30%)
		CBS repeat	769..812	CDD:341367
CLC-F	NP_564698.1	Voltage_gated_ClC	139..544	CDD:238233	116/555 (21%)
		PLN02274	<567..>673	CDD:215154	19/94 (20%)
		CBS_pair_voltage-gated_CLC_euk_bac	621..754	CDD:341368	11/38 (29%)
		CBS repeat	622..690	CDD:341368	11/37 (30%)
		CBS repeat	704..754	CDD:341368