Protein Alignment ClC-b and CLC-C

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_199800.1
• Gene: CLC-C / 835052
• AraportID: AT5G49890
• Length: 779
• Species: Arabidopsis thaliana
• Alignment Length: 865
• Identity: 271/865 - (31%)
• Similarity: 409/865 - (47%)
• Gaps: 155/865 - (17%)

  Fly     1 MDDRKALITLDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLLDD 65
            ||||.           |.|...::.|.|         .||..|.          .:||   :|||
plant     1 MDDRH-----------EGDHHDIEVEGG---------ALHGFER----------KISG---ILDD 32

  Fly    66 S-----QPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENT 125
            .     ||||..|                .:|..|...|       ..|:|...||||||:.||.
plant    33 GSVGFRQPLLARN----------------RKNTTSQIAI-------VGANTCPIESLDYEIFEND 74

  Fly   126 LFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPL 190
            .|:.:.|.|..... |:...::|.:...||:.|.|:....::.:|.::..|...:.|
plant    75 FFKQDWRSRKKIEI-LQYTFLKWALAFLIGLATGLVGFLNNLGVENIAGFKLLLIGN-------- 130

  Fly   191 SDASDRDLLIPYLYWLLF------SIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVR 249
                   |::...|:..|      :::.....|::..:|.|..||||||:||:||||:....|:.
plant   131 -------LMLKEKYFQAFFAFAGCNLILATAAASLCAFIAPAAAGSGIPEVKAYLNGIDAYSILA 188

  Fly   250 IKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDF 314
            ..||.||..|.|..|..|...||||||:|.||.:|..:.||.|..:...::..:.|::|.::||.
plant   189 PSTLFVKIFGSIFGVAAGFVVGKEGPMVHTGACIANLLGQGGSKKYRLTWKWLRFFKNDRDRRDL 253

  Fly   315 VLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTF 379
            :..|.||||:|||.||:||:||:||||||:|...|:|||.       ||..:|......|.:|..
plant   254 ITCGAAAGVAAAFRAPVGGVLFALEEAASWWRNALLWRTF-------FTTAVVAVVLRSLIEFCR 311

  Fly   380 T---GLFNLG---KFDT---PLKFDYFELPIFMILGVTGGLLGAAWNSLNTK-------INKFRK 428
            :   |||..|   .||.   |:.:...:|...:.|||.||:||:.:|.|..|       ||:...
plant   312 SGRCGLFGKGGLIMFDVNSGPVLYSTPDLLAIVFLGVIGGVLGSLYNYLVDKVLRTYSIINEKGP 376

  Fly   429 RFIPWKIGKVLEAVVVAMMGVTLACLM-IYFINDCRPL------GNDPTNNPVQLF----CEDNE 482
            ||      |::  :|:|:..::..|.. :.:::.|.|.      |..|:.....::    |..|.
plant   377 RF------KIM--LVMAVSILSSCCAFGLPWLSQCTPCPIGIEEGKCPSVGRSSIYKSFQCPPNH 433

  Fly   483 YNAVAALWFQTPEATVRSLFHD-PPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGA 546
            ||.:::|...|.:..:|:||.. ......|.|||:|.|..|.|...|:|:.:..|:|||..|.||
plant   434 YNDLSSLLLNTNDDAIRNLFTSRSENEFHISTLAIFFVAVYCLGIITYGIAIPSGLFIPVILAGA 498

  Fly   547 AWGRLLAMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLI-I 610
            ::|||:..|   :.|.:: |..|.::|:|||:.|||.:|||:||.|||:|.|  ......||: :
plant   499 SYGRLVGRL---LGPVSQ-LDVGLFSLLGAASFLGGTMRMTVSLCVILLELT--NNLLMLPLVML 557

  Fly   611 ALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEM 675
            .|:.:|.|.|.||.|:||..:.:..:|.:.....|..:.|.|::::|..:|.....:....|::.
plant   558 VLLISKTVADCFNRGVYDQIVTMKGLPYMEDHAEPYMRNLVAKDVVSGALISFSRVEKVGVIWQA 622

  Fly   676 LKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSI--QTFRDLY 738
            ||...||||||:|:......||  :|||.|||.|:|:|      :.|:|....|:.  |..|...
plant   623 LKMTRHNGFPVIDEPPFTEASE--LCGIALRSHLLVLL------QGKKFSKQRTTFGSQILRSCK 679

  Fly   739 PR-FP--------SIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLV 794
            .| |.        .|:.:...:|::...|||....|.||..|....|:.:...:||.||||||.|
plant   680 ARDFGKAGLGKGLKIEDLDLSEEEMEMYVDLHPITNTSPYTVLETLSLAKAAILFRQLGLRHLCV 744

  Fly   795 INH---ENRIAGIITRRDFI 811
            :..   ...|.||:||.||:
plant   745 VPKTPGRPPIVGILTRHDFM 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	186/558 (33%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	57/174 (33%)
		CBS repeat	657..763	CDD:341367	35/116 (30%)
		CBS repeat	769..812	CDD:341367	18/46 (39%)
CLC-C	NP_199800.1	ClC_6_like	64..586	CDD:239657	186/558 (33%)
		CBS_pair_voltage-gated_CLC_euk_bac	599..766	CDD:341367	57/174 (33%)
		CBS repeat	604..713	CDD:341367	35/116 (30%)
		CBS repeat	719..765	CDD:341367	18/46 (39%)