Protein Alignment ClC-b and CLC-A

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_198905.1
• Gene: CLC-A / 834090
• AraportID: AT5G40890
• Length: 775
• Species: Arabidopsis thaliana
• Alignment Length: 799
• Identity: 247/799 - (30%)
• Similarity: 405/799 - (50%)
• Gaps: 98/799 - (12%)

  Fly    63 LDDSQPLLMGNNSVPPDIPING-SAGSPNRNINSSEPIFHLRSRTAAASTP---------NYESL 117
            :|:...|.:.|::      .|| ..|....|...::|:  |:.....:|||         :.|||
plant     1 MDEDGNLQISNSN------YNGEEEGEDPENNTLNQPL--LKRHRTLSSTPLALVGAKVSHIESL 57

  Fly   118 DYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYN 182
            |||:.||.||:.:.|.| ::....:...::|.:...:|:.|.|||..|::.:|  :|..|..|
plant    58 DYEINENDLFKHDWRSR-SKAQVFQYIFLKWTLACLVGLFTGLIATLINLAVE--NIAGYKLL-- 117

  Fly   183 SVKENVPLSDASDRDLLIPYLYW---LLFS-----IVPVAFGAAMVTYIEPITAGSGIPQVKSYL 239
                .|....|.||       :|   ::|:     :..||  ..:|.|..|..||.|||::|:||
plant   118 ----AVGYYIAQDR-------FWTGLMVFTGANLGLTLVA--TVLVVYFAPTAAGPGIPEIKAYL 169

  Fly   240 NGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKA 304
            ||:..|.:....|:.||.:|.|.:|..||..|||||::|.|:.:|:.:.||........:|..:.
plant   170 NGIDTPNMFGFTTMMVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRY 234

  Fly   305 FRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLS 369
            |.:|.::||.:..|.|:||.|||.:|:||:||:|||.|::|...|:|||..::.:.|    :||.
plant   235 FNNDRDRRDLITCGSASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVV----VVLR 295

  Fly   370 AYHGLNDFTFTGLFNLG---KFD---TPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKI----N 424
            |:..:.:....|||..|   .||   ..:::...::....::||.||:||:.:|.|..|:    |
plant   296 AFIEICNSGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLLHKVLRLYN 360

  Fly   425 KFRKRFIPWKIGKVLEAVVVAMMGVTLACLM-IYFINDCRPLGND-----PTN----NPVQLFCE 479
            ...::   .||.|||.::.|::.  |..||. :.|:.:|:|....     |||    |..|..|.
plant   361 LINQK---GKIHKVLLSLGVSLF--TSVCLFGLPFLAECKPCDPSIDEICPTNGRSGNFKQFNCP 420

  Fly   480 DNEYNAVAALWFQTPEATVRSLF-HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTAL 543
            :..||.::.|...|.:..||::| .:.|....:::|.:|..:|.:|...|||:....|:|:|..|
plant   421 NGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFGMVSLWIFFGLYCILGLITFGIATPSGLFLPIIL 485

  Fly   544 VGAAWGRLL--AMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFF 606
            :|:|:||:|  ||.:|....|      |.||::|||:.:.|.:|||:||.||.:|.|  ......
plant   486 MGSAYGRMLGTAMGSYTNIDQ------GLYAVLGAASLMAGSMRMTVSLCVIFLELT--NNLLLL 542

  Fly   607 PL-IIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREI--LSKPVICIKIRDS 668
            |: :..|:.||.|||.||..||:..:.:..:|.|...|.|..:.|...|:  ...||:.:...:.
plant   543 PITMFVLLIAKTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTLNGVEK 607

  Fly   669 ANYIYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQ- 732
            ...|.::|:...||.|||:|.  .|:.:...:.|:|||:.|:.:|.|..::..|| ...|..::
plant   608 VANIVDVLRNTTHNAFPVLDG--ADQNTGTELHGLILRAHLVKVLKKRWFLNEKR-RTEEWEVRE 669

  Fly   733 --TFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVI 795
              |..:|..|..:...|.....::...|||....|.:|..|....||.:...:||::|||||||:
plant   670 KFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYTVVQSMSVAKALVLFRSVGLRHLLVV 734

  Fly   796 -----NHENRIAGIITRRD 809
                 :..:.:.||:||:|
plant   735 PKIQASGMSPVIGILTRQD 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	183/555 (33%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	48/168 (29%)
		CBS repeat	657..763	CDD:341367	28/108 (26%)
		CBS repeat	769..812	CDD:341367	17/46 (37%)
CLC-A	NP_198905.1	ClC_6_like	55..576	CDD:239657	183/555 (33%)
		CBS_pair_voltage-gated_CLC_euk_bac	596..757	CDD:341367	47/161 (29%)
		CBS repeat	596..702	CDD:341367	28/108 (26%)
		CBS repeat	708..756	CDD:341367	17/46 (37%)