Protein Alignment ClC-b and CLC-B

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_189353.1
• Gene: CLC-B / 822336
• AraportID: AT3G27170
• Length: 780
• Species: Arabidopsis thaliana
• Alignment Length: 802
• Identity: 257/802 - (32%)
• Similarity: 400/802 - (49%)
• Gaps: 115/802 - (14%)

  Fly    71 MGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTP---------NYESLDYEVCENTL 126
            :|.||     ..||..|.|..| ..::|:  :::....:|||         :.||||||:.||.|
plant     9 IGGNS-----NYNGEGGDPESN-TLNQPL--VKANRTLSSTPLALVGAKVSHIESLDYEINENDL 65

  Fly   127 FQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELS-------------IRKYT 178
            |:.:.||| ::...|:...::|.:...:|:.|.|||..|::.:|.::             .|..|
plant    66 FKHDWRKR-SKAQVLQYVFLKWTLACLVGLFTGLIATLINLAVENIAGYKLLAVGHFLTQERYVT 129

  Fly   179 FLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVK 243
            .|...|..|:.|:              |:.|::.|.|.        |..||.|||::|:|||||.
plant   130 GLMVLVGANLGLT--------------LVASVLCVCFA--------PTAAGPGIPEIKAYLNGVD 172

  Fly   244 IPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDD 308
            .|.:....|:.||.:|.|.:|..||..|||||::|.|:.:|:.:.||.:......:|..:.|.:|
plant   173 TPNMFGATTMIVKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGTDNHRIKWRWLRYFNND 237

  Fly   309 HEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHG 373
            .::||.:..|.||||.|||.:|:||:||:|||.|::|...|:|||..::.:.|    :||..:..
plant   238 RDRRDLITCGSAAGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVV----VVLREFIE 298

  Fly   374 LNDFTFTGLFNLG---KFD-TPLKFDYFELPIF--MILGVTGGLLGAAWNSLNTKI----NKFRK 428
            :.:....|||..|   .|| :.:.:.|....|.  |::||.||:||:.:|.|..|:    |...:
plant   299 ICNSGKCGLFGKGGLIMFDVSHVTYTYHVTDIIPVMLIGVIGGILGSLYNHLLHKVLRLYNLINE 363

  Fly   429 RFIPWKIGKVLEAVVVAMMGVTLACLM-IYFINDCRPLGND-----PTN----NPVQLFCEDNEY 483
            :   .||.|||.::.|::.  |..||. :.|:..|:|....     |||    |..|..|....|
plant   364 K---GKIHKVLLSLTVSLF--TSVCLYGLPFLAKCKPCDPSIDEICPTNGRSGNFKQFHCPKGYY 423

  Fly   484 NAVAALWFQTPEATVRSLF-HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAA 547
            |.:|.|...|.:..||:|| .:.|....:.:|.:|.|:|.:|...|||:....|:|:|..|:|||
plant   424 NDLATLLLTTNDDAVRNLFSSNTPNEFGMGSLWIFFVLYCILGLFTFGIATPSGLFLPIILMGAA 488

  Fly   548 WGRLL--AMLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPL-I 609
            :||:|  ||.:|....|      |.||::||||.:.|.:|||:||.||.:|.|  ......|: :
plant   489 YGRMLGAAMGSYTSIDQ------GLYAVLGAAALMAGSMRMTVSLCVIFLELT--NNLLLLPITM 545

  Fly   610 IALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREI--LSKPVICIKIRDSANYI 672
            |.|:.||.|||.||..|||..:.:..:|.|...|.|..:.|...|:  ...||:.::..:..:.|
plant   546 IVLLIAKTVGDSFNPSIYDIILHLKGLPFLEANPEPWMRNLTVGELGDAKPPVVTLQGVEKVSNI 610

  Fly   673 YEMLKKCDHNGFPVVDDV----CGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQT 733
            .::||...||.|||:|:.    .|.......:.|:|||:.|:.:|.|..::..||    .|....
plant   611 VDVLKNTTHNAFPVLDEAEVPQVGLATGATELHGLILRAHLVKVLKKRWFLTEKR----RTEEWE 671

  Fly   734 FRDLYP------RFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHL 792
            .|:.:|      |..:...|.....::...|||....|.:|..|..:.||.:...:||.:|||||
plant   672 VREKFPWDELAEREDNFDDVAITSAEMEMYVDLHPLTNTTPYTVMENMSVAKALVLFRQVGLRHL 736

  Fly   793 LVINHENR-----IAGIITRRD 809
            |::.....     :.||:||:|
plant   737 LIVPKIQASGMCPVVGILTRQD 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	193/560 (34%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	48/175 (27%)
		CBS repeat	657..763	CDD:341367	29/115 (25%)
		CBS repeat	769..812	CDD:341367	16/46 (35%)
CLC-B	NP_189353.1	ClC_6_like	54..575	CDD:239657	193/560 (34%)
		CBS_pair_voltage-gated_CLC_euk_bac	595..762	CDD:341367	47/168 (28%)
		CBS repeat	595..707	CDD:341367	29/115 (25%)
		CBS repeat	713..761	CDD:341367	16/46 (35%)