Protein Alignment ClC-b and clcn1a

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_009292335.1
• Gene: clcn1a / 795133
• ZFINID: ZDB-GENE-060503-333
• Length: 1011
• Species: Danio rerio
• Alignment Length: 855
• Identity: 207/855 - (24%)
• Similarity: 351/855 - (41%)
• Gaps: 210/855 - (24%)

  Fly   101 HLRSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIR------------------ 147
            |.|||:...|.|:   ||.|: .:...:.|:.:..|..|..|:...:
Zfish    64 HSRSRSRHHSRPH---LDLEI-GSIHDRPEEEQGHTSSFKKRRSYSKCRDCVARVQKFLVSKLGE 124

  Fly   148 -WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIV 211
             ||..:.:||..||::.::|....: |::.|.:.|..::.|:||.          ||.|:.:.:|
Zfish   125 DWIFLVLLGITMALVSWSMDYASAK-SLQAYKWFYGELRGNIPLQ----------YLVWVSYPMV 178

  Fly   212 PVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPM 276
            .:.|.:.....:.|...|||||::|:.|.||.:...:.:|....|.:|:...:..|:..|||||.
Zfish   179 LILFASLFCHLVAPQAIGSGIPEMKTILRGVVLKEYLTLKAFVAKVVGLTAGLGSGMPVGKEGPF 243

  Fly   277 IHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            :|..::.||.:|:     |:..|.  ..::..:...|.:..|.|.||...||.|:||:|||:|..
Zfish   244 VHIASICAAVLSK-----FMSFFS--GVYQSPYGYTDILTVGCAVGVGCCFGTPLGGVLFSIEVT 301

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFDYFELPIFMIL 405
            ::::.....||...|:..|.|... |||.:: .:..|.|.||... :.|.|  ||..|||.|.|:
Zfish   302 STYFAVRNYWRGYFAATFSAFIFR-VLSVFN-KDAVTITALFRTNFRMDFP--FDLQELPAFAII 362

  Fly   406 GVTGGLLGAAWNSLNTKINKFRK------RFIPWKIGKVLEAVVVAMMGVTLACLMIYFINDCRP 464
            |::.|.|||.:..||.::..|.:      ||:. |...|..||      |||....:.|     |
Zfish   363 GISCGFLGAFFVYLNRQVVLFMRRPNILTRFLT-KHRLVFPAV------VTLVVTTLTF-----P 415

  Fly   465 LGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHD-----------PPGSHK-------- 510
            .|             ..::.|...:    |...:.|||.:           |||..:
Zfish   416 PG-------------FGQFMAGELM----PRECINSLFDNFTWTKIWGSPLPPGLGRSAVWFHPD 463

  Fly   511 ---ILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEF------- 565
               .:.|.||.::.:.:|..:..:.:..|.|:|..::|||:|||:..:...:||....
Zfish   464 VSIFVILILFLIMKFWMSAVSTTMPIPSGAFMPVFVLGAAFGRLVGEIMATLFPHGILFDGILYR 528

  Fly   566 LHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQ 630
            :.||.||:||||| |.|.:..|:|.:||..|.|| :.|...|:::|:|.|..|.......:||:.
Zfish   529 IIPGGYAVIGAAA-LTGAVTHTVSTAVICFELTG-QISHILPMMVAVILANMVAQGLQPSLYDSI 591

  Fly   631 IQ---VNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCG 692
            ||   :.::|.|.:..:.|| .:...:|:.:.|..:..:.:...:..:|.......||:||.
Zfish   592 IQFKKLPYLPELGFGHISQY-NIFVEDIMVRKVKFLCSQSTYREVLHLLDSTSLKTFPLVDS--- 652

  Fly   693 DRRSEGRVCGIILRSQLIV-----------ILL-------------------------------- 714
              :....:.|.|.||:|:.           ||:
Zfish   653 --KDSMILLGSIERSELLALCDWWLSAERRILIQGQSPQGQVPCAKISWESFAFVDEDEEDEEEN 715

  Fly   715 ---KSLYVENKRFW--------LPETS--------IQTFRDLYPRFPSIKSVRKLD--------- 751
               |::.|:.:|..        .|.|:        .|:||.|.....|..|.|..:
Zfish   716 VDEKTIPVQEERNGPVPPPKPSEPSTNHTSPDKGPSQSFRRLLRNLFSSSSERHTEGQPQEPYPP 780

  Fly   752 --------EKINYTVDLSM---------FMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHEN 799
                    |:|....:..|         .::|||.::....|:.:...:|..|||.|..|.| ..
Zfish   781 PLTDTMTPEQIKAWEESEMDKPLEINQIRIDPSPFQLVERTSLHKTHTLFSLLGLSHAYVTN-TG 844

  Fly   800 RIAGIITRRD 809
            ::.|::..::
Zfish   845 KLVGVVALKE 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	157/581 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	41/246 (17%)
		CBS repeat	657..763	CDD:341367	28/193 (15%)
		CBS repeat	769..812	CDD:341367	9/41 (22%)
clcn1a	XP_009292335.1	ClC_1_like	125..602	CDD:239655	149/529 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	615..858	CDD:341367	41/246 (17%)
		CBS repeat	620..778	CDD:341367	25/162 (15%)
		CBS repeat	815..857	CDD:341367	9/41 (22%)