Protein Alignment ClC-b and Clcnkb

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_775126.1
• Gene: Clcnkb / 79430
• RGDID: 628639
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 724
• Identity: 170/724 - (23%)
• Similarity: 306/724 - (42%)
• Gaps: 145/724 - (20%)

  Fly   135 LTER-FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDL 198
            |.|| |.:.:|   |...:.:|::.|||:..::..|..: :|.:.:||..:.:.          .
  Rat    39 LKERLFRVGED---WYFLVALGVLMALISYAMNFAIGRV-VRAHKWLYREIGDG----------H 89

  Fly   199 LIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITS 263
            |:.||.|.::.:..::|.:.....|.|.:.|||||:||:.|.||.:...:.||....|.:|:..:
  Rat    90 LLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVVGLSCT 154

  Fly   264 VVGG--LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAA 326
            :..|  :..||.||.:|...::||.:.:.::.|..:.       .:..::.:.:..|.|.||:..
  Rat   155 LATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEP-------ENKTKEMELLAAGAAVGVATV 212

  Fly   327 FGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTP 391
            |.|||.|:|||:|..:|.::....||...|:....|..:: |:.::...: |.|.::.. .|...
  Rat   213 FAAPISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHL-LAVFNSEQE-TITSIYKT-SFPVD 274

  Fly   392 LKFDYFELPIFMILGVTGGLLGAAWNSLN------TKINKFRKRFIPWK--IGKVLEAVVVA--- 445
            :.||..|:..|:.||...|:|...:|...      .|.|.|..:.:...  :...|.|||:|
  Rat   275 IPFDLPEIFFFVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSKPLYSALAAVVLASIT 339

  Fly   446 -------MMGVTLAC---LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQ--TPEATV 498
                   .|...|:.   |...|.|:...|....::.|..  .|.:..|    ||.:  .|:.||
  Rat   340 YPPGVGRFMASRLSMSEYLETLFDNNSWALMTKNSSPPWS--AEPDPQN----LWLEWCHPQMTV 398

  Fly   499 RSLFHDPPGSHKILTLALFTVV-YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQ 562
            ..            ||..|.|: :::|..|| .:.:..|.|:|..:.|||.|||...:....||:
  Rat   399 FG------------TLVFFLVMKFWMLILAT-TIPIPAGYFLPIFVYGAAIGRLFGEVLSLAFPE 450

  Fly   563 -------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGD 620
                   ...:.||.|||.|||| ..|.:..|:|.:::..|.:| :.....|:::|:::|..:..
  Rat   451 GIVAGGKVSPIMPGAYALAGAAA-FSGAVTHTLSTALLAFEVSG-QIVHALPVLMAVLAANAICQ 513

  Fly   621 YFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPV---------ICIKIRDSANYIYEML 676
            .:....||..|.|..:|.|.|        ::.|:|.|..|         :....:|..  :.|::
  Rat   514 SYQPSFYDGTIIVKKLPYLPW--------IRGRKIGSHLVTVGHFMNCTLTTLAKDMP--LEEVI 568

  Fly   677 K---KCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDL 737
            |   ..|...:|:|:      .:|.:| .||:.|:.|:    :||:.::.. |.|...
  Rat   569 KVVISTDVTQYPLVE------TTESQVLVGIVKRTHLV----QSLHTDSAS-WAPGQQ------- 615

  Fly   738 YPRFPSIKSVRKLDEKINYTVDLSMFMN-----PSPIRVNPHDSVPRIFQIFRALGLRHLLVINH 797
                |.::.:               ..|     |..::::...|:.....:|..|.|: ||.:..
  Rat   616 ----PCLQDI---------------LANGCPTQPVTLQLSTETSLHETHNLFELLNLQ-LLFVTS 660

  Fly   798 ENRIAGIIT 806
            ..|..|.::
  Rat   661 RGRAVGSVS 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	137/537 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	31/173 (18%)
		CBS repeat	657..763	CDD:341367	19/118 (16%)
		CBS repeat	769..812	CDD:341367	8/38 (21%)
Clcnkb	NP_775126.1	ClC_1_like	49..533	CDD:239655	133/528 (25%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	27/164 (16%)
		CBS repeat	552..627	CDD:341367	18/113 (16%)
		CBS repeat	633..675	CDD:341367	8/38 (21%)