Protein Alignment ClC-b and clcn5

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001039210.1
• Gene: clcn5 / 734069
• XenbaseID: XB-GENE-5957241
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 892
• Identity: 235/892 - (26%)
• Similarity: 376/892 - (42%)
• Gaps: 239/892 - (26%)

  Fly    52 RRATLSGNNHLLDDSQPLLMG--------NNSVPP-DIPINGSAGSPNRN-INSSEPIFHLRSRT 106
            ||::|:..:....|...:.:.        .:.||| |..:.|...|.|.| ::....:.......
 Frog     7 RRSSLTSFHSSTSDEDMVEINEATLDFTMTDDVPPIDRDMAGGFVSYNGNGLHGPSKVMDFLDVP 71

  Fly   107 AAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIR--------WIIFIQIGIITALIAC 163
            ...:..::.::|: |.|.:..:|..|:.|::.......::|        |::.:.||:....:|.
 Frog    72 GVGTYEDFNTIDW-VREKSRDRDRHREILSKSKESTWALLRSISDAFSGWMLMLLIGLTAGSLAG 135

  Fly   164 TIDI-------IIEELSIRKYTFLYNSV---KENVPLSDASD-------RDLLI-------PY-- 202
            .|||       :.|.:.:..:.|.:...   ..||...|.::       ..|::       ||
 Frog   136 LIDISSHWMTDLKEGICLPWFWFNHEQCCWQSNNVTFEDRNNCPEWRSWSQLVLGRSEGAFPYIL 200

  Fly   203 ------LYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVI 261
                  |:.||||::.|    .:|....|...|||||::|:.|:|..|...:...||.:|.:.::
 Frog   201 NYFMYVLWALLFSLLAV----LLVRNFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKTMTLV 261

  Fly   262 TSVVGGLAGGKEGPMIH----AGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAA 321
            .:|..||:.|||||:||    .|.::.               .:|..:|.:..||..|| ...||
 Frog   262 LAVSSGLSLGKEGPLIHVACCCGNILC---------------HLFTKYRKNEAKRREVLSAAAAA 311

  Fly   322 GVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFN 384
            |||.||||||||:||||||.:.::....:||:..|::::.|||       ..:|.|  :...||.
 Frog   312 GVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFY 369

  Fly   385 LGKFDTPLKFDYFELPIFMILGVTGGLLGA-------AW--NSLNTKINKFRKRFIPWKIGKVLE 440
            : :|..|  :...||..|::||:.|||.||       ||  ....||:.::          .|.|
 Frog   370 V-EFHAP--WHLLELIPFILLGIFGGLWGAFFIRGNIAWCQRRKTTKLGRY----------PVAE 421

  Fly   441 AVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYN---------- 484
            .:||..:...||.           ::....|||..|.:....:.|      |:||
 Frog   422 VLVVTAITAVLAFPNDYTRMSSSEMISELFNDCGLLDSSKLCDYV------NDYNNTKGGNLPDR 480

  Fly   485 -----AVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALV 544
                 ...|:|                      .|:|..:...|::..|||:.|..|:|||:..|
 Frog   481 AAGNGVYTAMW----------------------QLSLALIFKAVITIFTFGMKVPSGLFIPSMAV 523

  Fly   545 GAAWGRLLAM----LTYY-----VF-----PQAEFLHPGKYALIGAAANLGGVLRMTISLSVILM 595
            ||..||||.:    |::|     :|     ..|:.:.||.||::||||.|||..|||:||.||:.
 Frog   524 GAIMGRLLGVAMEQLSFYHHDWLIFRGWCNQGADCITPGLYAMVGAAACLGGATRMTVSLVVIMF 588

  Fly   596 ETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL--- 656
            |.|| ...:..||:.|.:::|||.|.. .|.|||..|.:|..|.|..:....:|.| |.:::
 Frog   589 ELTG-GLEYIVPLMAAAMTSKWVADALGRESIYDAHIHLNGYPFLEAKEEFSHKTL-AMDVMRPR 651

  Fly   657 -SKPVICIKIRDSANY--IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLY 718
             :.|::.:..:||...  |..::.:..::|||:|..     |...|:.|.:||..||:
 Frog   652 RNDPILTVITQDSMTVEDIEAIINETTYSGFPIVIS-----RESQRLVGFVLRRDLII------- 704

  Fly   719 VENKRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYT-------------------VDLSMFM 764
                                    |::|.||..|.|..|                   :.|...|
 Frog   705 ------------------------SVESARKKQEGIVSTSQIYFTEHTPPQPPTAPPSLKLRAIM 745

  Fly   765 NPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            :.||..:.....:..:..|||.||||..|| .|..|:.||||::|.:
 Frog   746 DLSPFTITDQTPMEIVVDIFRKLGLRQCLV-THNGRLLGIITKKDVL 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	177/620 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	43/185 (23%)
		CBS repeat	657..763	CDD:341367	23/126 (18%)
		CBS repeat	769..812	CDD:341367	16/43 (37%)
clcn5	NP_001039210.1	ClC_3_like	127..632	CDD:239656	168/572 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	643..793	CDD:341367	44/187 (24%)
		CBS repeat	649..744	CDD:341367	23/130 (18%)
		CBS repeat	750..792	CDD:341367	16/43 (37%)