Protein Alignment ClC-b and Clcn4

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_006256890.1
• Gene: Clcn4 / 60586
• RGDID: 708381
• Length: 774
• Species: Rattus norvegicus
• Alignment Length: 844
• Identity: 233/844 - (27%)
• Similarity: 381/844 - (45%)
• Gaps: 199/844 - (23%)

  Fly    74 NSVPPDIPINGSAGSPNRNIN----SSEPIFHLRSRTAAASTPNYESLDYEVCENTLFQDEQRKR 134
            ||: |.:....|||:.:.:.|    ..||.      ....:..::.::|: :.|.:...|..||
  Rat     7 NSL-PGVTSTVSAGAMSASGNLMDFLDEPF------PDVGTYEDFHTIDW-LREKSRDTDRHRK- 62

  Fly   135 LTER-----FSLRKDII----RWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPL 190
            :|.:     :...|.::    .|::.:.||::...:|..||:.::.::         .:||.|.|
  Rat    63 ITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMT---------DLKEGVCL 118

  Fly   191 S----------------DASDRD---------------------LLIPYLYWLLFSIVPVAFGAA 218
            |                ...|||                     .::.||.::|::::......:
  Rat   119 SAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWALLFAFLAVS 183

  Fly   219 MVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVV 283
            :|....|...|||||::|:.|:|..|...:...||.:|.:.::..|..||:.|||||::|    |
  Rat   184 LVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVH----V 244

  Fly   284 AAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQN 348
            |.......|:.|      .|..:::.::|:.:....|||||.||||||||:||||||.:.::...
  Rat   245 ACCCGNFFSSLF------SKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLK 303

  Fly   349 LIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGL 411
            .:||:..|::::.|||       ..:|.|  :...||.: ::.||  :...||..|::|||.|||
  Rat   304 TLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EYHTP--WYMAELFPFILLGVFGGL 358

  Fly   412 LGAAWNSLNTKINKFRKRFIPW-------KIGK--VLEAVVVAMMGVTLAC-----------LMI 456
                |.::.|:.|      |.|       ::||  |||.:||..:...:|.           |:.
  Rat   359 ----WGTVFTRCN------IAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQSTSELIS 413

  Fly   457 YFINDCRPLG--------NDPT-NNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKIL 512
            ...|||..|.        |||. ..||    :|                     ..|.|....:.
  Rat   414 ELFNDCGALESSQLCDYINDPNMTRPV----DD---------------------IPDRPAGVGVY 453

  Fly   513 T----LALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VF---- 560
            |    |||..:...|::..|||:.:..|:|||:..|||..||::.:    |.|:     :|
  Rat   454 TAMWQLALALIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWC 518

  Fly   561 -PQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF-N 623
             |.|:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|.| .
  Rat   519 RPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAVTSKWVADAFGK 582

  Fly   624 EGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKCDHN 682
            ||||:..|.:|..|.|..:....::.| |.:::    .:|.:.:..:||...  :..::|:.|:|
  Rat   583 EGIYEAHIHLNGYPFLDVKDEFTHRTL-ATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYN 646

  Fly   683 GFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSV 747
            |||||..     |...|:.|...|.:||:.:..:   ..::..:...||..|.:..|..|:
  Rat   647 GFPVVVS-----RDSERLIGFAQRRELILAIKNA---RQRQEGIVSNSIMYFTEEPPELPA---- 699

  Fly   748 RKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
                 ...:.:.|...:|.||..|..|..:..:..|||.||||..|| ....|:.||||::|.:
  Rat   700 -----NSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLV-TRSGRLLGIITKKDVL 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	178/619 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	44/166 (27%)
		CBS repeat	657..763	CDD:341367	23/107 (21%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
Clcn4	XP_006256890.1	ClC_3_like	92..598	CDD:239656	169/570 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	609..759	CDD:341367	45/168 (27%)
		CBS repeat	615..710	CDD:341367	23/111 (21%)
		CBS repeat	716..758	CDD:341367	17/43 (40%)