Protein Alignment ClC-b and clcn2c

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001306200.1
• Gene: clcn2c / 563453
• ZFINID: ZDB-GENE-050506-73
• Length: 810
• Species: Danio rerio
• Alignment Length: 762
• Identity: 178/762 - (23%)
• Similarity: 329/762 - (43%)
• Gaps: 163/762 - (21%)

  Fly   148 WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVP 212
            ||..:.:|.|...|:..:||.: :|....:.::|.||         :|..:::.||.|:.:|::.
Zfish    59 WIFLMILGFILGTISFLMDIFV-DLFTDAHRWIYYSV---------ADYHVVVQYLVWVSYSMIL 113

  Fly   213 VAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG-LAGGKEGPM 276
            :.|.|.....:.|...|||||::|:.|.||.:...:..:||..|.:. :|.|:|. |..|||||.
Zfish   114 MCFAAGFANIVSPQAVGSGIPEMKTALRGVVMQEYLTFRTLVSKVVS-LTCVLGSELPVGKEGPF 177

  Fly   277 IHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            :|.|::.|:.:.:     |:..|.  ..::::...::.:..|.|.|:...|.:||||.|||:|..
Zfish   178 VHIGSLCASLLCK-----FMALFS--NIYKNEARNKELLTVGCAVGIGCCFASPIGGALFSIEVT 235

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILG 406
            |.::.....||..:::........: |..:| ..:.|...|: ..|:.....||..|||:|:.:|
Zfish   236 AMYYLPRNYWRAFLSATFGAIIFRL-LPVWH-REEETLMALY-ATKYRLDFPFDLQELPVFVAMG 297

  Fly   407 VTGGLLGAAWNSLNTKINKF------------RKRFIPWKIGKVLEAVVVAMMG--------VTL 451
            :..||.||.:..|..||..|            |..|....:..||.:.:....|        :|.
Zfish   298 IVCGLGGAFFVFLYGKITLFVKEKKASNSLLMRNCFYYSALTSVLISTLTFPPGFGQFMAGKLTQ 362

  Fly   452 ACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLAL 516
            ...:|.|.:|     ...:|:.:....:||::   .|.| :.|.|.|            .:.|.:
Zfish   363 RYSLISFFDD-----RTWSNHSIVKDFDDNDH---LAAW-KHPYANV------------FVVLFV 406

  Fly   517 FTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL--AMLTYY---------VFPQAEFLHPGK 570
            |.::.:.:|..:..|.:..|.|:|..::||.:|||:  .|.|.:         ::|    :.||.
Zfish   407 FVIMKFWMSALSITLPIPCGSFVPIFVIGAGFGRLIGEGMATLFPEGFNTDGHIYP----IVPGA 467

  Fly   571 YALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVN- 634
            ||::||||...||.. |:|.:||:||.|| ..|:..|::|::|.:..|.......||||.|::.
Zfish   468 YAVVGAAALTAGVTH-TMSTAVIMMELTG-HLSYSLPILISVILSNMVSQSLQPSIYDTVIRIKR 530

  Fly   635 --HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSE 697
              ::|:|.|......| :...:.:::.|..|.:..:...::::|...:....|:|      :.:|
Zfish   531 LPYLPLLRWGQRENSK-IHVEDFMNRDVRFITLNSTYRDVFKILCSGNLKTVPMV------KSTE 588

  Fly   698 GR-VCGIILRSQLIVILL-KSLYVENKRFWLP-----------ETSIQTFRDLYPRFPSIKSVRK 749
            .. :.|.|.|:||:.:|: ::.|:....:.:|           |.|......:.|..| :||..|
Zfish   589 SMLLLGSIERAQLLALLIERTQYLRGGAYSIPARSKVHFQTATEDSSSASAQVSPSTP-LKSALK 652

  Fly   750 -------------------------------------------------------LDEKINYTVD 759
                                                                   |||::|:.
Zfish   653 RPTADEEQLNNNVYDSGLSFKTFFCSRPDTDAMKNDPDAHDDMILQEIEKWEEQQLDEQVNFN-- 715

  Fly   760 LSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIIT 806
             |..::|:|.::....::.:...:|..|.|.:..|.: ..|:.|:::
Zfish   716 -SCQIDPAPFQLVDRTTLHKTHSMFSVLNLDYAFVTS-VGRLVGVVS 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	141/525 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	34/223 (15%)
		CBS repeat	657..763	CDD:341367	26/173 (15%)
		CBS repeat	769..812	CDD:341367	6/38 (16%)
clcn2c	NP_001306200.1	ClC_1_like	58..535	CDD:239655	140/523 (27%)
		CBS_pair_SF	548..767	CDD:449531	34/224 (15%)
		CBS repeat	554..718	CDD:341358	26/173 (15%)
		CBS repeat	724..766	CDD:341358	6/38 (16%)