Protein Alignment ClC-b and clcn3

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_001923503.1
• Gene: clcn3 / 559340
• ZFINID: ZDB-GENE-030131-1699
• Length: 874
• Species: Danio rerio
• Alignment Length: 881
• Identity: 246/881 - (27%)
• Similarity: 391/881 - (44%)
• Gaps: 209/881 - (23%)

  Fly    47 TSALARRATLSGNNHLLD----DSQPLLMGNNSVPPDIPI-NGSAGSPNRNINS------SEPIF 100
            |||.:....|.|...::|    :...||.|:.|...:..: ||..|....:.::      .|||
Zfish    20 TSASSDEELLDGAGVIMDFHTTEDDNLLDGDASPGSNYAMSNGGGGGGGASSSTHLLDLLEEPI- 83

  Fly   101 HLRSRTAAASTPNYESLDY--EVCENTLFQDEQR------KRLTERFSLRKDII----RWIIFIQ 153
                 ....:..::.::|:  |.|     :|.:|      |:....:...|.:.    .|::...
Zfish    84 -----PGVGTYDDFHTIDWVREKC-----KDRERHRKINSKKKESAWEFTKSLYDAWSGWLVVTL 138

  Fly   154 IGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLS----------------DASDRDLLIPY 202
            .|:.:..:|..|||..:.:         |.:||.|.||                ..::||....:
Zfish   139 TGLASGALAGGIDIAADWM---------NDLKEGVCLSAMWFNHEQCCWGSNKTTFAERDKCPQW 194

  Fly   203 LYW------------------LLFSIVPVAF---GAAMVTYIEPITAGSGIPQVKSYLNGVKIPR 246
            ..|                  .:|:...::|   ..::|....|...|||||::|:.|:|..|..
Zfish   195 KTWAELILGQEQGPGSYIMNYFMFTFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRG 259

  Fly   247 IVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEK 311
            .:...||.:|.|.::.:|..||:.|||||::|.....      |...::|    ..|..:::.:|
Zfish   260 YLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCC------GNIFSYL----FPKYSKNEAKK 314

  Fly   312 RDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLND 376
            |:.:....|||||.||||||||:||||||.:.::....:||:..|::::.|.|       ..:|.
Zfish   315 REVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVL-------RSINP 372

  Fly   377 F--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRK--RFIPWKIGK 437
            |  :...||.: ::.||  :..|||..|::|||.|||.||.:...|....:.||  ||     ||
Zfish   373 FGNSRLVLFYV-EYHTP--WYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTRF-----GK 429

  Fly   438 --VLEAVVVAMMGVTLAC-----------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAAL 489
              |||.:.||.:...:|.           |:.....||.||.:.      || |:
Zfish   430 YPVLEVITVAAITAIVAFPNPYTRQNTSELIKELFTDCGPLESS------QL-CQ---------- 477

  Fly   490 WFQTPEATVRSLFH----DP----------PGSHKIL-TLALFTVVYYVLSCATFGLNVSLGVFI 539
                    .|||.:    ||          ||.:..: .|:|..|...:::..||||.|..|:||
Zfish   478 --------YRSLMNGSQADPTGPDTASAATPGVYSAMWQLSLALVFKIIMTIFTFGLKVPSGLFI 534

  Fly   540 PTALVGAAWGRLLAM----LTYY-----VFPQ-----AEFLHPGKYALIGAAANLGGVLRMTISL 590
            |:..:||..||::.:    |.||     ||.:     |:.:.||.||::||||.||||.|||:||
Zfish   535 PSMAIGAIAGRIVGIAVEQLAYYHHDWFVFREWCEVGADCITPGLYAMVGAAACLGGVTRMTVSL 599

  Fly   591 SVILMETTGVETSFFFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKARE 654
            .||:.|.|| ...:..||:.|::::|||||.| .||||:..|::|..|.|..:....:..| |||
Zfish   600 VVIVFELTG-GLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTL-ARE 662

  Fly   655 IL----SKPVICIKIRDSANY--IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVIL 713
            ::    |.|.:.:..:|....  :..::.:..:|||||:..     :...|:.|..||..:
Zfish   663 VMRPRRSDPPLAVLTQDDMTLAELQGIISETSYNGFPVIVS-----KESQRLVGFALRRDI---- 718

  Fly   714 LKSLYVEN---KRFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHD 775
              ::.:||   |:..:...|...|....|..|: .|.|.|  |:...:|:      ||..|..|.
Zfish   719 --TIAIENARRKQEGIVLNSRVYFTQHAPTLPA-DSPRPL--KLRSILDM------SPFTVTDHT 772

  Fly   776 SVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .:..:..|||.||||..|| .|...:.||||:::.:
Zfish   773 PMEIVVDIFRKLGLRQCLV-THNGIVLGIITKKNIL 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	183/619 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	45/169 (27%)
		CBS repeat	657..763	CDD:341367	24/110 (22%)
		CBS repeat	769..812	CDD:341367	16/43 (37%)
clcn3	XP_001923503.1	ClC_3_like	140..648	CDD:239656	175/567 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	659..809	CDD:341367	46/171 (27%)
		CBS repeat	665..760	CDD:341367	23/108 (21%)
		CBS repeat	766..808	CDD:341367	16/43 (37%)