Protein Alignment ClC-b and clcn5b

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_685762.3
• Gene: clcn5b / 557584
• ZFINID: ZDB-GENE-110407-11
• Length: 811
• Species: Danio rerio
• Alignment Length: 860
• Identity: 243/860 - (28%)
• Similarity: 387/860 - (45%)
• Gaps: 185/860 - (21%)

  Fly    57 SGNNHLLDDSQPLLMGNNSVPPDIPINGSAG--SPNRNINSSEPIFHLRSRTAAASTPNYESLDY 119
            |.::.|:|.|...:..|..||| :..:.|.|  ..:...|||..:..|...:...:..::.::|:
Zfish    15 SSDDELVDISDVTVDYNEDVPP-LDRDYSTGHCKADWRPNSSPKLMDLLDVSGIGTYEDFNTIDW 78

  Fly   120 EVCENTLFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIR 175
             |.|.:..:|..|: :|.:         ||:......|::.:.||:::..:|..|||....::..
Zfish    79 -VREKSRDRDRHRE-ITNKSKHSTLALIFSISDAFSGWLLMLLIGLMSGALAGGIDIAAHWMTDL 141

  Fly   176 K----------------YTFLYNSVKEN-------------VPLSDASDRDLLIPYLY------- 204
            |                :|:...:.||.             |.:|:::     :.|.|
Zfish   142 KEGVCLDGFWFNHEDCCWTYNGTTFKERDKCPQWKSWAELMVGVSEST-----VWYAYMASYFMY 201

  Fly   205 --W-LLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVG 266
              | |.||.:.|    .:|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..
Zfish   202 VCWALFFSFLAV----ILVRAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKTITLVLAVSS 262

  Fly   267 GLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331
            ||:.|||||::|.....|..:..     |...:|     |::.::|:.:....|.|||.||||||
Zfish   263 GLSLGKEGPLVHVACCCANILCH-----FFTKYR-----RNEAKRREVLSAASAVGVSVAFGAPI 317

  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKF 394
            ||:||||||.:.::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :
Zfish   318 GGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--W 372

  Fly   395 DYFELPIFMILGVTGGLLGA-------AWNSL--NTKINKFRKRFIPWKIGKVLEAVVVAMMGVT 450
            .:.||..|::||:.|||.||       ||..|  ||....:          .|||.::|.::...
Zfish   373 HFLELIPFILLGIFGGLWGAFFIRANIAWCRLRKNTSFGHY----------PVLEVIIVTLVTAF 427

  Fly   451 LA-----------CLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHD 504
            ||           .|:....|||..|.:....|          |.:|......:..||:.:...|
Zfish   428 LAFPNEFTRMSSSTLISELFNDCSLLDSSKLCN----------YTSVGGGRGGSVNATIANALAD 482

  Fly   505 PPGSHKILT----LALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY--- 558
            .|....:.|    |||..:...|::.||||:.|..|:|||:..|||..||||.:    |..|
Zfish   483 RPAGPGLYTAMWQLALALLFKMVMTVATFGMKVPSGLFIPSMAVGAIAGRLLGVFMEQLAVYHHD 547

  Fly   559 --VF-----PQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAK 616
              :|     |..:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|
Zfish   548 WAIFRGWCSPGTDCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSK 611

  Fly   617 WVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRD--SANYIYE 674
            ||.|.| .|.||:..|::|..|.|..:...::|.| |.:::    |.|.:.:..:.  |...:..
Zfish   612 WVADAFGRESIYEAHIRLNGYPFLEAKEEFRHKTL-ATDVMRPRRSDPPLSVLTQSGMSVEEVER 675

  Fly   675 MLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKR---FWLPETSIQTFRD 736
            ::....::|||||..:     :..|:.|.:||..||:.|      ||.|   ..:...|...|.:
Zfish   676 LIADTTYSGFPVVLSL-----TSQRLVGFVLRRDLIISL------ENARRHQEGVVSVSAVLFTE 729

  Fly   737 LYPRF-----PSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVIN 796
            ..|..     |::|              |...::.||..|..|..:..:..|||.||||..|| .
Zfish   730 CDPPASPNAPPAVK--------------LRSILDLSPFTVTVHTPMEIVVDIFRKLGLRQCLV-T 779

  Fly   797 HENRIAGIITRRDFI 811
            ...|:.||||::|.:
Zfish   780 QNGRLLGIITKKDIL 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	182/612 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	44/174 (25%)
		CBS repeat	657..763	CDD:341367	24/115 (21%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)
clcn5b	XP_685762.3	None