Protein Alignment ClC-b and ClC-a

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_788639.1
• Gene: ClC-a / 41428
• FlyBaseID: FBgn0051116
• Length: 1193
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 192/721 - (26%)
• Similarity: 309/721 - (42%)
• Gaps: 148/721 - (20%)

  Fly   128 QDEQR-KRLTERFSLR-KDIIRWI------------IFIQ-IGIITALIACTIDIIIEELSI--R 175
            :|:|| |.|..:.|.| |.:..||            :|:. :|||.||::..:|   :.:||  .
  Fly   137 EDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD---KGISICTN 198

  Fly   176 KYTFLYNSVKENVPLSDASDRDL----LIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVK 236
            ...:||              |||    .:.|:.|:...:..:.|.|..|..|.|.:.|||||::|
  Fly   199 ARIWLY--------------RDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMK 249

  Fly   237 SYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRI 301
            :.|.||::...:..|||..|.||:..::..|:..|||||.:|..::||..:|  |..|..:..
  Fly   250 TILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLS--KLVTSFQGI-- 310

  Fly   302 FKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNI 366
               :.::....:.:....|.||.|.|.||:||:|||:|...:::.....||...|::.......:
  Fly   311 ---YENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRL 372

  Fly   367 VLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAW----------NSLNT 421
            :...:.  |..|...|| |..|.|...||..||.:|.::|:..||.||::          ...|.
  Fly   373 LAVWFQ--NADTVRALF-LTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNK 434

  Fly   422 KINKF--RKRFI-PWKIGKVLEAVVVAM-MGVTLACLMIYFINDCRPLGNDPTNNPV-QLF---- 477
            ::|||  :.||: |..:..::.::...: .|..||             |...|:..| |||
  Fly   435 RMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLA-------------GELSTHEQVTQLFSNFT 486

  Fly   478 -CEDN---EYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVF 538
             ..|:   |..||...|.    .:..|:|.:         |.::|:..:|:|.....:.|..|:|
  Fly   487 WSRDDLTVEQAAVVTHWM----TSYTSVFGN---------LVIYTLFTFVVSIIASTIPVPSGMF 538

  Fly   539 IPTALVGAAWGRLLAMLTYYVFP-------QAEFLHPGKYALIGAAANLGGVLRMTISLSVILME 596
            ||...:||.:|||:.......||       :...:.||.||::||||..|.|.. |:|::||:.|
  Fly   539 IPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTH-TVSVAVIIFE 602

  Fly   597 TTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVI 661
            .|| :.:...|::||::.|..|.......|||:.|.:..:|.|. :.||...|:     .|..|.
  Fly   603 MTG-QITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLP-DLLPSSSGM-----YSIFVE 660

  Fly   662 CIKIRDSANYI-----YEMLKKC-----DHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKS 716
            ...:|| ..||     |:.||:.     .....|:||.     .....:.|.:.|.:||.::.|.
  Fly   661 DFMVRD-VKYIWHGISYQKLKEVLKLNKTLRSLPLVDS-----PDNMILLGSVQRYELIKMIEKH 719

  Fly   717 LYVENK----RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSV 777
            :..|.:    :.|..|...:...               :||....|:|.| ..||...|.|...:
  Fly   720 IGREKRMEVAQKWQKEAQERALE---------------EEKKKQEVELKM-RRPSRFEVLPAPDI 768

  Fly   778 PRIFQI 783
            ..:.||
  Fly   769 LSLRQI 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	157/561 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	31/146 (21%)
		CBS repeat	657..763	CDD:341367	24/119 (20%)
		CBS repeat	769..812	CDD:341367	4/15 (27%)
ClC-a	NP_788639.1	ClC_1_like	171..646	CDD:239655	148/530 (28%)
		CBS_pair_SF	659..>718	CDD:449531	15/64 (23%)
		CBS repeat	664..715	CDD:341358	14/56 (25%)
		CBS_pair_SF	<1032..1096	CDD:449531
		CBS repeat	1053..1095	CDD:341358