Protein Alignment ClC-b and Clcn6

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001099949.1
• Gene: Clcn6 / 295586
• RGDID: 1305379
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 819
• Identity: 289/819 - (35%)
• Similarity: 434/819 - (52%)
• Gaps: 134/819 - (16%)

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.|..:. |..:.:..:...|.:.::|::...||:.|.|:...:|..:...:..|:
  Rat    47 DYESLDYDRCINDPYL-EVLETMDNKKGRRHEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKF 110

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .|.:..|...|..||...:...|.|:::..|||:.||||||::|.|||||
  Rat   111 GVVQTSVEE------CSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGV 169

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.|||::||..|..||:.||.|||..||||||||:||||.||:.|.:|.:..|....|..||.
  Rat   170 KVPGIVRLRTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRS 234

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.
  Rat   235 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 299

  Fly   371 YHGLNDFTFTGLFNLGKF---DTPLK---FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|   |:..|   :...:|..|:::||.||||||.:|.||.::.|:|.|
  Rat   300 FGSWGAFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMR 364

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPL------GN---------DPTNNPVQ- 475
            .:   | |:.:|||:::|:::...:..:....:.:||.:      ||         :..|:.::
  Rat   365 NVHPKP-KLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKT 428

  Fly   476 LFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIP 540
            .||.::.||.:|.|:|.:.|:.:..|||. .|:...:|||||..:|::::|.|||.:|..|:|:|
  Rat   429 FFCPNDTYNDMATLFFNSQESAILQLFHQ-DGTFSPVTLALFFALYFLMACWTFGTSVPSGLFVP 492

  Fly   541 TALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604
            :.|.|||:|||:| :|..|:  ....|:.|.:|||||||.||||:||||||:|||:|:|. |.::
  Rat   493 SLLCGAAFGRLVANVLKSYI--GLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EITY 554

  Fly   605 FFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSA 669
            ..|:::.|:.|||.||:||:||||..|.:..||:|.||...:...|:|.:|:...:..:......
  Rat   555 GLPIMVTLMVAKWTGDFFNKGIYDIHIGLRGVPLLEWETEVEMDRLRASDIMEPNLTYVYPHTRI 619

  Fly   670 NYIYEMLKKCDHNGFPVVDD----------------------------VCGDRRSEGR------- 699
            ..:..:|:...|:.||||.:                            ..|::|..|:
  Rat   620 QSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPS 684

  Fly   700 -----VC----------------------------------------------------GIILRS 707
                 ||                                                    |::|||
  Rat   685 SELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRS 749

  Fly   708 QLIVILLKSL-YVENK-RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIR 770
            ||:.:|::.: |.|:: ....|..|.....:.|||||.|..:..........||::.:|||||..
  Rat   750 QLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFT 814

  Fly   771 VNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            |:|:..|.::|.:||.:|||||.|:|....|.|||||.:
  Rat   815 VSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHN 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	228/551 (41%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	56/252 (22%)
		CBS repeat	657..763	CDD:341367	30/199 (15%)
		CBS repeat	769..812	CDD:341367	19/41 (46%)
Clcn6	NP_001099949.1	ClC_6_like	49..589	CDD:239657	228/551 (41%)
		CBS_pair_voltage-gated_CLC_euk_bac	601..854	CDD:341367	56/253 (22%)
		CBS repeat	607..807	CDD:341367	30/199 (15%)
		CBS repeat	813..854	CDD:341367	19/41 (46%)