Protein Alignment ClC-b and Clcn7

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_036060.1
• Gene: Clcn7 / 26373
• MGIID: 1347048
• Length: 803
• Species: Mus musculus
• Alignment Length: 823
• Identity: 387/823 - (47%)
• Similarity: 528/823 - (64%)
• Gaps: 69/823 - (8%)

  Fly     2 DDRKA--LITLDGESSAEDDPIILQKEAGPTSKAVQDFGLHQREEPSTSALARRATLSGNNHLLD 64
            ||.:.  |:...|:.. |:.|::  ..|||        |..|    |.|||.|...:  ||..||
Mouse    16 DDEEGAPLLRRTGQPD-EETPLL--NGAGP--------GARQ----SHSALFRIGQM--NNVELD 63

  Fly    65 DS--QPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYEVCENTLF 127
            |.  .|.:...::.|.:||.|             |.:..|:          ||||||:..||.||
Mouse    64 DELLDPEVDPPHTFPKEIPHN-------------EKLLSLK----------YESLDYDNSENQLF 105

  Fly   128 QDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSD 192
            .:|:| |:........:|.||:|...|||:|.|:||.|||::|.|:..|    |..:|:|:
Mouse   106 LEEER-RINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLK----YRVIKDNI---- 161

  Fly   193 ASDR-----DLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKT 252
              |:     .|....|.|...:...|..|:.:|.:|||:.|||||||:|.:|||||||.:||:||
Mouse   162 --DKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKT 224

  Fly   253 LAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLG 317
            |.:|..|||.|||||||.||||||||:|:|:|||||||:||:..:||:||:.||.|.||||||..
Mouse   225 LVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSA 289

  Fly   318 GGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHG-LNDFTFTG 381
            |.|||||||||||:||:||||||.||||||.|.||...||:||.||||.|||.||| :.|.:..|
Mouse   290 GAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPG 354

  Fly   382 LFNLGKFDT-PLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKVLEAVVVA 445
            |.|.|:||: .:.:...|:|:|:.:||.||:|||.:|:||..:..||.|:|.....:|:||::||
Mouse   355 LINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVA 419

  Fly   446 MMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHK 510
            .:..|:|.::||...||:||.....:.|:||||.|.|||::||.:|.|||.:|.|||||||||:.
Mouse   420 AVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYN 484

  Fly   511 ILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQAEFLHPGKYALIG 575
            .:||.|||:||:.|:|.|:||.||.|||||:.|:|||||||..:...|:...|.:..||||||:|
Mouse   485 PMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMG 549

  Fly   576 AAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLT 640
            |||.|||::|||:||:||:||.|. ..::.||:::.|::||.|||.|.||:||..||:..||.|.
Mouse   550 AAAQLGGIVRMTLSLTVIMMEATS-NVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH 613

  Fly   641 WEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLK--KCDHNGFPVVDDVCGDRRSEGRVCGI 703
            ||.......|.|||::|.||.|::.|:....|.::|.  ..:|||||||:|| ||.: ..|:.|:
Mouse   614 WEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDV-GDTQ-PARLQGL 676

  Fly   704 ILRSQLIVILLKSLYVENKRFWLPE--TSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNP 766
            ||||||||:|...::||.....|.:  ..::.|||.|||||.|:|:....::...|:|||.||||
Mouse   677 ILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNP 741

  Fly   767 SPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            ||..|....|:||:|::|||||||||:|:::.|::.|::||:|
Mouse   742 SPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKD 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	279/530 (53%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	75/162 (46%)
		CBS repeat	657..763	CDD:341367	46/109 (42%)
		CBS repeat	769..812	CDD:341367	20/41 (49%)
Clcn7	NP_036060.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46		10/40 (25%)
		ClC_6_like	93..618	CDD:239657	282/536 (53%)
		Selectivity filter part_1. /evidence=ECO:0000250	201..205		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	243..247		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	510..514		3/3 (100%)
		CBS_pair_voltage-gated_CLC_euk_bac	624..788	CDD:341367	75/163 (46%)
		CBS repeat	630..738	CDD:341367	46/109 (42%)
		CBS repeat	744..787	CDD:341367	20/41 (49%)