Protein Alignment ClC-b and Clcn6

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_036059.1
• Gene: Clcn6 / 26372
• MGIID: 1347049
• Length: 870
• Species: Mus musculus
• Alignment Length: 819
• Identity: 289/819 - (35%)
• Similarity: 434/819 - (52%)
• Gaps: 134/819 - (16%)

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            :||||||:.|.|..:. |..:.:..:...|.:.::|::...||:.|.|:...:|..:...:..|:
Mouse    47 DYESLDYDRCINDPYL-EVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKF 110

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            ..:..||:|      .|.:..|...|..||...:...|.|:::..|||:.||||||::|.|||||
Mouse   111 GVVQTSVEE------CSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGV 169

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|.|||::||..|..||:.||.|||..||||||||:||||.||:.|.:|.:..|....|..||.
Mouse   170 KVPGIVRLRTLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRS 234

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSA-- 370
            |.:|||||..|.||||:|||||||||.||||||.:|||||.|.|:.|..|:.:.||||...|.
Mouse   235 DRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQ 299

  Fly   371 YHGLNDFTFTGLFNLGKF---DTPLK---FDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKR 429
            :.....|...||.|.|:|   |:..|   :...:|..|:::||.||||||.:|.||.::.|:|.|
Mouse   300 FGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMR 364

  Fly   430 FI---PWKIGKVLEAVVVAMMGVTLACLMIYFINDCRPL------GN---------DPTNNPVQ- 475
            .:   | |:.:|||:::|:::...:..:....:.:||.:      ||         :..|:.::
Mouse   365 NVHPKP-KLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKA 428

  Fly   476 LFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIP 540
            .||.::.||.:|.|:|.:.|:.:..|||. .|:...:|||||.::|::|:|.|||.:|..|:|:|
Mouse   429 FFCPNDTYNDMATLFFNSQESAILQLFHQ-DGTFSPVTLALFFILYFLLACWTFGTSVPSGLFVP 492

  Fly   541 TALVGAAWGRLLA-MLTYYVFPQAEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604
            :.|.|||:|||:| :|..|:  ....|:.|.:|||||||.||||:||||||:|||:|:|. |.::
Mouse   493 SLLCGAAFGRLVANVLKSYI--GLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTN-EITY 554

  Fly   605 FFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSA 669
            ..|:::.|:.|||.||.||:||||..|.:..||:|.||...:...|:|.:|:...:..:......
Mouse   555 GLPIMVTLMVAKWTGDLFNKGIYDVHIGLRGVPLLEWETDVEMDKLRASDIMEPNLTYVYPHTRI 619

  Fly   670 NYIYEMLKKCDHNGFPVVDD----------------------------VCGDRRSEGR------- 699
            ..:..:|:...|:.||||.:                            ..|::|..|:
Mouse   620 QSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPS 684

  Fly   700 -----VC----------------------------------------------------GIILRS 707
                 ||                                                    |::|||
Mouse   685 SELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRS 749

  Fly   708 QLIVILLKSL-YVENK-RFWLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIR 770
            ||:.:|::.: |.|:: ....|..|.....:.|||:|.|..:..........||::.:|||||..
Mouse   750 QLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFT 814

  Fly   771 VNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRD 809
            |:|:..|.::|.:||.:|||||.|:|....|.|||||.:
Mouse   815 VSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHN 853

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	229/551 (42%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	55/252 (22%)
		CBS repeat	657..763	CDD:341367	29/199 (15%)
		CBS repeat	769..812	CDD:341367	19/41 (46%)
Clcn6	NP_036059.1	ClC_6_like	49..589	CDD:239657	229/551 (42%)
		Selectivity filter part_1. /evidence=ECO:0000250	156..160		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	198..202		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	488..492		2/3 (67%)
		CBS_pair_voltage-gated_CLC_euk_bac	601..854	CDD:341367	55/253 (22%)
		CBS repeat	607..807	CDD:341367	29/199 (15%)
		CBS repeat	813..854	CDD:341367	19/41 (46%)