Protein Alignment ClC-b and clh-2

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_001364585.1
• Gene: clh-2 / 174738
• WormBaseID: WBGene00000529
• Length: 878
• Species: Caenorhabditis elegans
• Alignment Length: 883
• Identity: 212/883 - (24%)
• Similarity: 363/883 - (41%)
• Gaps: 217/883 - (24%)

  Fly    45 PSTSALARRATLS---GNNHLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRT 106
            |.|| :|..||.:   .||.:.|..:.||    .:.|....:.:...|:.::.|:|......:|.
 Worm    16 PPTS-IAVIATTNKDIDNNVMSDVKRSLL----DMSPGGKTDDADEEPDDHVESNETFAEFCTRQ 75

  Fly   107 AAASTPNYESLDYEVCENT---LFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDII 168
            |               :|.   |.:|                  |.:...:|||||:::..:|:.
 Worm    76 A---------------QNVVHFLVED------------------WFLSALLGIITAVLSVGMDVA 107

  Fly   169 IEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIP 233
            ||.|.....|| |:.:     |:.:|    .:.:..|:...::...|.|.....:.....|||||
 Worm   108 IEVLQHAHVTF-YDKM-----LAISS----YLAFSQWVAHIVILTMFAAIFCQIVSKQAVGSGIP 162

  Fly   234 QVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKD 298
            :||..::|.|:...:..:||..|.:|:..::.|||..|||||.:|.||:||..:|:..|......
 Worm   163 EVKVIMHGFKMENYLTTRTLVAKMVGLTLAMGGGLPIGKEGPFVHMGAIVATLLSKITSACQYSA 227

  Fly   299 FRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFT 363
            |     |.::..:.:.:..|.|.|::..|.||||.:|:::|..:.::.....||..:|:..|...
 Worm   228 F-----FSNEGREMEMLSSGCAVGIACTFSAPIGAVLYAIESTSKYFAVKNYWRGFLAATCSAIV 287

  Fly   364 L---NIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYF---ELPIFMILGVTGGLLGAAWNSLNTK 422
            .   |..::|.   ...|.|..:.. :|.|    |.|   |||||::||...||:|:.:..::.:
 Worm   288 FRCANFFVTAE---QSGTITAFYQT-RFPT----DCFLVEELPIFLLLGFISGLMGSFFIFIHRQ 344

  Fly   423 INKFRKRFIPWKI--------GKVLEAVVVAMM------------GVTLACLMIYFINDCRPLGN 467
            |:.||.:...:|:        ..|..|.||.::            .:|....|..|.|:|..:.|
 Worm   345 ISIFRSKNRVYKLIFRNNFLAFTVFMAFVVGVLTFPNGLGRYFAGRLTFRETMADFFNNCTWVSN 409

  Fly   468 DPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLN 532
            |....|          :.:...|....|..| |:|         .:|.|:.::|:||......:|
 Worm   410 DSRRCP----------DTILTHWTGGSEGDV-SIF---------TSLVLYYILYFVLVAICISIN 454

  Fly   533 VSLGVFIPTALVGAAWGRLLAMLTYYVFPQ------AEFLHPGKYALIGAAANLGGVLRMTISLS 591
            |..|||:|:.::|||.|||:......:||:      ...:|||.||::||||..|.|.. |:|:|
 Worm   455 VPAGVFVPSFIIGAAGGRLMGETMVVLFPEGMRGPGGPPIHPGLYAVVGAAAYTGAVTH-TLSVS 518

  Fly   592 VILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYK----GLKA 652
            ||:.|.|| :.|...|::||::....|..:....||::.|:|...|.|  ..||..:    .:|.
 Worm   519 VIICELTG-QLSPILPVLIAMLMGNAVCKFLQPSIYESIIRVKKYPYL--PDLPPSRVSVHTVKV 580

  Fly   653 REILSKPVICIKIRDSANYIYEMLKKCDH-NGFPVVDDVCGDRRSEGRV-CGIILRSQLIVILLK 715
            .:::...||.|....:...:.|:|:...| ..||:|.|      .|.:: .|.:.:..|.::|.:
 Worm   581 EQLMVTDVIYITKDMTYREMKEILQLAPHLRSFPIVTD------HENKILLGSVAKRYLTMLLRR 639

  Fly   716 SLYV------------------------------------------ENKRFWLPET--------- 729
            .:.|                                          ||.   :|||
 Worm   640 HVLVNQQDSRNIGRMTPSEIFNTIRRTSMRLSRRSPSRRSNSSQTRENS---VPETARSDAPSDQ 701

  Fly   730 ---------SIQTFRDLYPRF-------------PSIKSVRK----LDEKINYTVDL-SMFMNPS 767
                     |..|...:.|..             ||...:.|    .|..:|..:|| .:.::.:
 Worm   702 VEFVSERTISGNTLLSISPLHCPNNIPLQAVFTRPSSADLSKTETNADILLNRNIDLDEIAIDAA 766

  Fly   768 PIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGII 805
            |.::....|:.::..:|..|||.|..|.:. .::.|::
 Worm   767 PFQLVLGSSLYKVHTLFSLLGLSHAYVTDC-GKLVGVV 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	152/558 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	39/234 (17%)
		CBS repeat	657..763	CDD:341367	30/185 (16%)
		CBS repeat	769..812	CDD:341367	8/37 (22%)
clh-2	NP_001364585.1	ClC_1_like	86..567	CDD:239655	151/545 (28%)
		CBS_pair_SF	580..809	CDD:449531	39/234 (17%)
		CBS repeat	585..761	CDD:341358	30/184 (16%)
		CBS repeat	768..809	CDD:341358	8/37 (22%)