Protein Alignment ClC-b and clh-5

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: NP_495940.1
• Gene: clh-5 / 174449
• WormBaseID: WBGene00000532
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 881
• Identity: 225/881 - (25%)
• Similarity: 377/881 - (42%)
• Gaps: 219/881 - (24%)

  Fly    52 RRATLSGNNHLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRT-----AAAST 111
            |.:||...     |...|.....|....:.:....||.:.:.|....|..:|.:|     ...:.
 Worm     6 RSSTLGST-----DDVELEPSGTSATIHLDMTAGGGSSSSDFNPFGAIDDVRFKTDDDLPDVMAP 65

  Fly   112 P------NYESLDYEVCENTLFQDEQRKRLTERFSLRKDI--------------IRWIIFIQIGI 156
            |      ::.::|::       :|..|.||..:...:|.:              ..||..:.:|:
 Worm    66 PFFSKYGDFHTIDWQ-------RDLARDRLRHKMISKKKVDFPLGLLQSGWDAGAGWICVLFVGL 123

  Fly   157 ITALIACTIDIIIEELSIRKY--------------------TF-----------------LYNSV 184
            .....|..|||....:|..|.                    ||                 .|||
 Worm   124 AAGATAGIIDIGARWMSDLKTGVCADRFWLDHEHCCWSSNDTFYKDDDCKAWTKWPWMLNYYNS- 187

  Fly   185 KENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIE---PITAGSGIPQVKSYLNGVKIPR 246
                       ...|..:|.|:.:....||.....|.:::   |...|||||::|..|:|..|..
 Worm   188 -----------SSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPYACGSGIPEIKCILSGFVIRG 241

  Fly   247 IVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF-RDDHE 310
            .:...|..:|::|:|.|...||:.||||||:|....:      |...::|     |..: .::.:
 Worm   242 YLGKWTFIIKSVGLILSSASGLSLGKEGPMVHLACCI------GNIFSYL-----FPKYGLNEAK 295

  Fly   311 KRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLN 375
            ||:.:....|||||.||||||||:|||||||:.::....:||:...::::...|..|       |
 Worm   296 KREILSASAAAGVSVAFGAPIGGVLFSLEEASYYFPLKTMWRSFFCALVAGIILRFV-------N 353

  Fly   376 DF--TFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGKV 438
            .|  ..|.||::   |..:|:.:.||..|.|||:.||::|:.:...|.:.::|||.      .|:
 Worm   354 PFGSNQTSLFHV---DYMMKWTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRKN------SKM 409

  Fly   439 LEA-VVVAMMGVTLACLMIYFINDCRPLGNDPTNNPV-QLF--CEDNEYNAVAALWFQTPEATVR 499
            |.. .:..:|.:||....|.:.|   |.......:.: |||  |||           |..|.::.
 Worm   410 LGGNPIYEVMLITLVTAAISYFN---PFTRKSAQSMIQQLFDRCED-----------QIDEDSLC 460

  Fly   500 SLFHDPPGSHKILTLA----LFTVVY-YVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYV 559
            .       .:|.|::|    |:.::: :|::..|||:.|..|:|:|:..:||..||:|.:....:
 Worm   461 D-------QNKALSIAFGQLLWALIFKFVITIFTFGIKVPCGLFVPSIGMGAIAGRILGITVDQI 518

  Fly   560 F--PQA--------------EFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPL 608
            |  .||              :.:.||.||::||||.||||.|||:||.||:.|.|| ...|..|.
 Worm   519 FRAVQATPGHSDYFTCQIGKDCVMPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTG-SLEFIVPT 582

  Fly   609 IIALISAKWVGDYFNE-GIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANY- 671
            ::|.:.:||:||..:: |||:..|::|..|.|  :...:|........:.:|.|..::.|..:.
 Worm   583 MVATMFSKWIGDGISKMGIYEAHIELNGYPFL--DSKGEYPYSTVASQVMRPSIHRQVADEMSMS 645

  Fly   672 ---------------------IYEMLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLK 715
                                 :..:|::.|.||||||..     ::...:.|.|.|..:::
 Worm   646 DLRELKNELSVITESGMTLGDLESLLRQTDFNGFPVVVS-----QNSMHLVGFITRRDILL---- 701

  Fly   716 SLYVENK-RFWLPETSIQTFR----DLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHD 775
            :|:...| :.::...||..|.    |..|..|:...:||:             ::.:|:.|....
 Worm   702 ALHTARKTQPYVVTNSIAYFSDGVPDAMPGGPAPLRLRKI-------------LDMAPMTVTDQT 753

  Fly   776 SVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            .:..:..:||.|||||:||..: .::.||||::|.:
 Worm   754 PMETVIDMFRKLGLRHVLVTKN-GKVLGIITKKDIL 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	170/606 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	40/187 (21%)
		CBS repeat	657..763	CDD:341367	24/132 (18%)
		CBS repeat	769..812	CDD:341367	15/43 (35%)
clh-5	NP_495940.1	ClC_3_like	122..614	CDD:239656	162/552 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	654..790	CDD:341367	37/158 (23%)
		CBS repeat	654..741	CDD:341367	20/95 (21%)
		CBS repeat	747..789	CDD:341367	15/43 (35%)