Protein Alignment ClC-b and ClC-a

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_061498046.1
• Gene: ClC-a / 1273077
• VectorBaseID: AGAMI1_005630
• Length: 1150
• Species: Anopheles gambiae
• Alignment Length: 829
• Identity: 209/829 - (25%)
• Similarity: 344/829 - (41%)
• Gaps: 203/829 - (24%)

  Fly     4 RKALITLDGESSAEDDPI-----ILQKEAGPTSKAVQDFGLHQREE--------PSTSALARRAT 55
            |.||:.|...::....|:     :::|. .|....|:..|:.....        |:||:.:.|::
Mosquito    48 RNALLVLAKTAAIVPPPLGHQQRVVEKN-DPGEMPVRPDGVENGSRNSETSACLPTTSSSSSRSS 111

  Fly    56 LSGNNHLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPIFHLRSRTAAASTPNYESLDYE 120
            .: |.|....|..:|:...| |.|.|    |||...:::.::.....||           .:|.|
Mosquito   112 TT-NMHTSSRSNAMLIDVPS-PDDCP----AGSGLDDLDPADKDEIRRS-----------IVDIE 159

  Fly   121 VCE------------NTLFQDEQRK-RLTERFSLRKDIIR------------------------- 147
            :.|            ....:||.|: ||.||...:.|..|
Mosquito   160 IEEFYYMYGRYTKDLGEYAKDEARRLRLLERRRKKDDKARNKELLDVRDNKFFKAASWLWRNTFA 224

  Fly   148 -----WIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDL----LIPYL 203
                 |:....:|||.||::..:|..| .:......:||              |||    ::.||
Mosquito   225 RLGEDWVFLALLGIIMALLSYVMDKGI-SMCTNSRVWLY--------------RDLTNHPVLQYL 274

  Fly   204 YWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGL 268
            .|:...:..:.|.|..|..:.|.:.|||||::|:.|.||.:...:..|||..|.||:..::..|:
Mosquito   275 AWVSLPVCLILFSAGFVHLVAPQSIGSGIPEMKTILRGVALKEYLTFKTLVAKVIGLTATLGSGM 339

  Fly   269 AGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKR----DFVLGGGAAGVSAAFGA 329
            ..|||||.:|..::|:..:|           :|..:|:..:|..    :.:....|.||.|.|.|
Mosquito   340 PLGKEGPFVHIASIVSQLLS-----------KIITSFQSIYENESRNTEMLAAACAVGVGACFAA 393

  Fly   330 PIGGMLFSLEEAASFWNQNLIWRTLVASI--ISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPL 392
            ||||:|||:|...:::.....||...|::  .:||.|   |:.:....| |.|.:|:. .|.:..
Mosquito   394 PIGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRL---LAVWFQKAD-TVTAMFST-NFTSDF 453

  Fly   393 KFDYFELPIFMILGVTGGLLGA--AW--------NSLNTKINKFRKRFIPWKIGKVLEAVVVAMM 447
            .||..||.:|.::|:..||.||  .|        ...|.|:|||.::      .:.|...:||::
Mosquito   454 PFDPQELFVFALIGLVCGLGGALYVWVHRKYVLFMRSNKKMNKFLQK------NRFLYPGIVALI 512

  Fly   448 GVTLACLMIYFINDCRPL-------GNDPTNNPV-QLFCEDN--------EYNAVAALWFQTPEA 496
            ..||:.          ||       |...|::.| |||....        |..||.:.| :|||.
Mosquito   513 VATLSF----------PLGFGKYIAGELSTHDQVHQLFSNFTWTKHELTVEQAAVVSNW-RTPET 566

  Fly   497 TVRSLFHDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFP 561
            .|            ...|.::.:..:.:|.....:.|..|:|||...:|||:||::....:..||
Mosquito   567 NV------------FANLIIYLLYTFFMSIIASTIPVPSGMFIPVFKIGAAFGRIIGEAMHLWFP 619

  Fly   562 Q--------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWV 618
            .        |..: ||.|:::|||| ..|.:..|:|:.||:.|.|| :.:...|::||.:.:..|
Mosquito   620 HGVRYGGMLAPII-PGGYSVVGAAA-FSGAVTHTVSVGVIVFEMTG-QITHIVPVMIAALISNAV 681

  Fly   619 GDYFNEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYI-----YEMLKK 678
            .......:||:.|.:..:|.|. :.||...|:     .:..|....:|| ..||     |:.||:
Mosquito   682 AALLQPSMYDSIILIKKLPYLP-DLLPSGSGM-----YNIYVEDFMVRD-VRYIWKGISYQQLKE 739

  Fly   679 C-----DHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENK 722
            .     .....|:||.  .|.|:   :.|.:.|.:||.::.|.:..|.:
Mosquito   740 ILKANKSLRSLPIVDS--PDNRT---LLGSVQRYELIKMIDKHIGREKR 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	160/610 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	19/81 (23%)
		CBS repeat	657..763	CDD:341367	19/76 (25%)
		CBS repeat	769..812	CDD:341367
ClC-a	XP_061498046.1	None