DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-b and Clcn1

DIOPT Version :10

Sequence 1:NP_610798.1 Gene:ClC-b / 36381 FlyBaseID:FBgn0033755 Length:813 Species:Drosophila melanogaster
Sequence 2:NP_038519.1 Gene:Clcn1 / 12723 MGIID:88417 Length:994 Species:Mus musculus


Alignment Length:780 Identity:186/780 - (23%)
Similarity:325/780 - (41%) Gaps:194/780 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 QKEAGPTSKA--VQDFGLHQREEPSTSALARRATLSGNNHLLDDSQPLLMGNNSVPPDIPINGSA 86
            :|:.||...|  .|.:| ||:|:.|..|             .|...|..||::|           
Mouse    47 RKDMGPRHNAHPTQIYG-HQKEQYSYKA-------------QDGGMPKKMGSSS----------- 86

  Fly    87 GSPNRNINSSEPIFHLRSRTAAASTPNYESLD---YEVCENTLFQDEQ--RKRLTERFSLRKDII 146
                                      ..:|||   |..|::.:.:..:  |::|.|         
Mouse    87 --------------------------TMDSLDEDHYSKCQDCVHRLGRVLRRKLGE--------- 116

  Fly   147 RWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIV 211
            .||..:.:|::.||::..:|.:..: |::.|.:.|..:|.::||.          ||.|:.|.::
Mouse   117 DWIFLVLLGLLMALVSWCMDYVSAK-SLQAYKWTYAQMKPSLPLQ----------YLAWVTFPLI 170

  Fly   212 PVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPM 276
            .:.|.|.....|.|...|||||::|:.|.||.:...:.:|....|.:.:...:..|:..|||||.
Mouse   171 LILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPF 235

  Fly   277 IHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEA 341
            :|..::.||.:|:     |:..|.  ..:...:...|.:..|.|.||...||.|:||:|||:|..
Mouse   236 VHIASICAAVLSK-----FMSMFS--GVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVT 293

  Fly   342 ASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFDYFELPIFMIL 405
            ::::.....||...|:..|.|...::  |....:..|.|.||... :.|.|  ||..|||.|.::
Mouse   294 STYFAVRNYWRGFFAATFSAFVFRVL--AVWNKDAVTITALFRTNFRMDFP--FDLKELPAFAVI 354

  Fly   406 GVTGGLLGAAWNSLNTKI------NKFRKRFI--------------------PWKIGKVL----- 439
            |:..|.|||.:..|:.::      :|...:|:                    |..:|:.:     
Mouse   355 GICCGFLGAVFVYLHRQVMLGVRKHKCLSQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELM 419

  Fly   440 --EAVVVAMMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLF 502
              ||:.......|    .:..|.|.:.||.                   :|:|.. |:..|    
Mouse   420 PREAISTLFDNNT----WVKHIGDPQSLGQ-------------------SAVWLH-PQVNV---- 456

  Fly   503 HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQA---- 563
                    |:.:.||.|:.:.:|.....:.:..|.|:|..::|||:|||:..:...:||:.    
Mouse   457 --------IIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFD 513

  Fly   564 EFLH---PGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEG 625
            :.::   ||.||:||||| |.|.:..|:|.:||..|.|| :.:...|:::|:|.|..|.......
Mouse   514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTG-QIAHILPMMVAVILANMVAQSLQPS 576

  Fly   626 IYDTQIQVN---HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVV 687
            :||:.|||.   ::|.|.|..|.::. :...:|:.:.|..:....:...:..:|:.......|:|
Mouse   577 LYDSIIQVKKLPYLPDLGWNQLSKFT-IFVEDIMVRDVKFVSASCTYGELRNLLQATTVKTLPLV 640

  Fly   688 DDVCGDRRSEGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKSVRKLDE 752
            |.     :....:.|.:.||:|..:|.:.|..|.:        ::..:|:         .|||.|
Mouse   641 DS-----KDSMILLGSVERSELQSLLQRHLCAERR--------LKAAQDM---------ARKLSE 683

  Fly   753  752
            Mouse   684  683

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-bNP_610798.1 ClC_6_like 115..639 CDD:239657 149/572 (26%)
CBS_pair_voltage-gated_CLC_euk_bac 652..813 CDD:341367 18/101 (18%)
CBS repeat 657..763 CDD:341367 17/96 (18%)
CBS repeat 769..812 CDD:341367
Clcn1NP_038519.1 ClC_1_like 117..592 CDD:239655 140/534 (26%)
Selectivity filter part_1. /evidence=ECO:0000250 188..192 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 230..234 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 482..486 2/3 (67%)
CBS_pair_SF 605..875 CDD:449531 18/101 (18%)
CBS repeat 610..826 CDD:341358 17/96 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 710..770
CBS repeat 832..874 CDD:341358
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 971..994
Blue background indicates that the domain is not in the aligned region.

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