Protein Alignment ClC-b and ClC-b

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_308378.5
• Gene: ClC-b / 1269729
• VectorBaseID: AGAMI1_010294
• Length: 760
• Species: Anopheles gambiae
• Alignment Length: 767
• Identity: 465/767 - (60%)
• Similarity: 583/767 - (76%)
• Gaps: 21/767 - (2%)

  Fly    56 LSGNNHLLD----DSQPLL---MGNNSVPPDIPINGSAGSPNRNINSS-EPIFHLRSRTAAASTP 112
            :|....|:|    |.:.||   :.|...|.:.|.:.:..:.|.:.:.. :|.|:|..|:..||
Mosquito     1 MSPGVRLIDVDSSDEENLLEEGVRNRRSPRNEPTDFNIPATNDDDDDDVDPAFNLNRRSKEAS-- 63

  Fly   113 NYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKY 177
            .||||||:||||.|::.:|.| :..:|::|||..||:|.:|||:.|||:||.|:|:|||:|..||
Mosquito    64 QYESLDYDVCENVLWRRDQTK-IKPKFTVRKDFSRWVISLQIGVCTALVACCINIVIEEVSRLKY 127

  Fly   178 TFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGV 242
            .||...|..||     ...||.||||||.|.::|||..||.:|.|:||:.|||||||||.|||||
Mosquito   128 GFLKRQVDANV-----LHGDLSIPYLYWSLLNLVPVVIGATLVAYVEPVAAGSGIPQVKCYLNGV 187

  Fly   243 KIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRD 307
            |:|||||||||||||:||.|||:|||||||||||||:|||:||||||||||||.:|.:|.:.|||
Mosquito   188 KVPRIVRIKTLAVKAVGVATSVIGGLAGGKEGPMIHSGAVIAAGISQGKSTTFRRDLKILQHFRD 252

  Fly   308 DHEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYH 372
            ||||||||:||.||||:|||||||||:|||||||||||||:|||||..|||||.|||||:|||||
Mosquito   253 DHEKRDFVVGGAAAGVAAAFGAPIGGILFSLEEAASFWNQSLIWRTFFASIISSFTLNIILSAYH 317

  Fly   373 GLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK 437
            ||:.|.:.||||||:| .||.|:|:||||||::||.||..||.||:||:::|.||...|..:..|
Mosquito   318 GLSSFRYRGLFNLGEF-APLPFEYYELPIFMLMGVIGGCTGALWNALNSRLNMFRAHAIRQRWAK 381

  Fly   438 VLEAVVVAMMGVTLACLMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLF 502
            ||||..||::|.|.||||.|.||||||||||||..||||||:||||||.||||||||||||::||
Mosquito   382 VLEAAFVAVLGATFACLMAYTINDCRPLGNDPTEQPVQLFCQDNEYNAAAALWFQTPEATVKALF 446

  Fly   503 HDPPGSHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLTYYVFPQA-EFL 566
            |||||||||||||.|.::||.|||.|:||:||||:||||.|:|||||||:|..|...||.: .|:
Mosquito   447 HDPPGSHKILTLATFVLIYYPLSCVTYGLSVSLGIFIPTLLIGAAWGRLIASFTVLAFPTSIAFV 511

  Fly   567 HPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQI 631
            .|||||||||||.||||:|||:||||||:|||| ...|..|:|:.|::|||.|||||||||||||
Mosquito   512 SPGKYALIGAAAQLGGVVRMTLSLSVILLETTG-NIGFILPIILTLMTAKWSGDYFNEGIYDTQI 575

  Fly   632 QVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRS 696
            :.:.||||.|...|:|:.|.||.|:::||:|::..:...|:.::||...|||||||:|.....|.
Mosquito   576 RTSRVPMLPWHVEPEYQNLSARHIMARPVVCVRTEEKVQYLLDILKNTTHNGFPVVEDGDDGSRV 640

  Fly   697 EGRVCGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRDLYPRFPSIKS--VRKLDEKINYTVD 759
            .||:.|:||||||:|||.:|.|||:.|||....||:.|||.|||:|:::.  |.:.....:::|:
Mosquito   641 NGRLIGLILRSQLVVILKRSFYVESSRFWESTVSIEAFRDEYPRYPAVEDLHVNEYKRSGSFSVN 705

  Fly   760 LSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRRDFI 811
            ::|||||||..|....|||||||:|||||||||:|::.|||:.|||||:||:
Mosquito   706 MNMFMNPSPYSVEEGTSVPRIFQLFRALGLRHLVVVSSENRVRGIITRKDFL 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	359/524 (69%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	83/162 (51%)
		CBS repeat	657..763	CDD:341367	45/107 (42%)
		CBS repeat	769..812	CDD:341367	28/43 (65%)
ClC-b	XP_308378.5	None