Protein Alignment ClC-b and clcn2b

DIOPT Version :10

• Sequence 1: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Sequence 2: XP_009302317.2
• Gene: clcn2b / 100333644
• ZFINID: ZDB-GENE-151006-1
• Length: 911
• Species: Danio rerio
• Alignment Length: 868
• Identity: 203/868 - (23%)
• Similarity: 358/868 - (41%)
• Gaps: 237/868 - (27%)

  Fly    35 QDFGLHQREEPSTSALARRATLSGNNHLLDDSQPLLMGNNSVPPDIPINGSAGSPNRNINSSEPI 99
            |:.|::.|||.:              .|.:|                     |...|:|:...|.
Zfish    24 QELGVYAREEAA--------------RLRED---------------------GRQRRSISERSPS 53

  Fly   100 FHL-----------RSRTAAASTPNYESLDYEVCENTLFQDEQRKRLTERFSLRKDIIRWIIFIQ 153
            ..|           |....|::.|::.|:....|              :||.:.:....||..|.
Zfish    54 LKLLEYEKGRCVKCRRFAYASAPPDFFSVCAVHC--------------QRFLMSRVGEDWIFLIL 104

  Fly   154 IGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAA 218
            :|::.||::..:|..| .|.::...::|..:..||          ::.||.|:.:.:|.::|.|.
Zfish   105 LGLVMALVSFVMDFCI-ALLLQAQKWMYGGLDSNV----------VLQYLAWVTYPVVLISFSAG 158

  Fly   219 MVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVV 283
            ....:.|..||||||::|:.|.||.:...:.:||...|.:|:..::..||..|||||.:|..::.
Zfish   159 FTHIVAPQAAGSGIPEMKTILRGVVLKEYLTLKTFVAKVVGLTCALGSGLPLGKEGPFVHIASLC 223

  Fly   284 AAGISQGKSTTFLKDFRIFKAFRDDHEKR--DFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWN 346
            ||         .|..|..|.....::|.|  :.:....|.||...|.|||||:|||:|..::|:.
Zfish   224 AA---------LLCKFMSFFGGIYENESRNIEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFA 279

  Fly   347 QNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGL 411
            ....||...|:..|.|...::  |....::.|.|.||.. :|.....||..|||.|.::|:..|.
Zfish   280 VRNYWRGFFAATFSAFIFRVL--AVWNRDEETITALFKT-RFRLDFPFDLQELPAFAVIGIASGF 341

  Fly   412 LGAAWNSLNTKINKFRK------RFIPWKIGKVLEAVVVAMMGVTLA-----------------C 453
            .||.:..||..|.:|.:      :|:..|  ::|...:|.::..||:                 .
Zfish   342 GGALFVYLNRLIVQFMRKQKTINKFLMKK--RLLYPALVTLLISTLSFPPGFGQFMAGQLTQKET 404

  Fly   454 LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAALWFQTPEATVRSLFHDPPGSHKILTLALFT 518
            |:.:|         |......|...||..::.....| :.|:|.|            .:.|.:|.
Zfish   405 LVSFF---------DNRTWAKQGISEDFTFDTHLMAW-KHPQANV------------FIILVIFI 447

  Fly   519 VVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL--AMLTYY---------VFPQAEFLHPGKYA 572
            |:.:.:|.....|.|..|.|:|..::|||:|||:  :|..::         ::|    :.||.||
Zfish   448 VMKFWMSALATTLPVPCGAFMPVFVIGAAFGRLVGESMAAWFPEGINTDGTIYP----IVPGGYA 508

  Fly   573 LIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYFNEGIYDTQIQVN--- 634
            ::|||| |.|.:..|:|.:||:.|.|| :.|...|::||:|.|..|.......|||:.|::.
Zfish   509 VVGAAA-LSGAVTHTVSTAVIVFELTG-QISHILPIMIAVILANAVAQSLQPSIYDSIIRIKKLP 571

  Fly   635 HVPMLTWEPLPQYKGLKAREILSKPVICIKIRDSANYIYEMLKKCDHNGFPVVDDVCGDRRSEGR 699
            ::|.|.|....:| .::..:|:.:.|..|.:..:...:.::|             :.|:.::...
Zfish   572 YLPELGWGHHEKY-NIRVEDIMVRDVRYITLNSTYRDLQDIL-------------MIGNLKTVAL 622

  Fly   700 V--------CGIILRSQLIVILLKSL-------------YVENKRFWLPETSIQTFRDLYPRFPS 743
            |        .|.|.|:||..:|::.:             ..|.||..:..:.           .|
Zfish   623 VESADSMILLGSIERAQLQALLVQQVSRVRRQEVMRERAETERKRMSVASSP-----------SS 676

  Fly   744 IKSVRKLDEKINYTV--DLSMF-----MNPSPIR----------------VNPHDSVPRIFQIFR 785
            ..|.:|:::::.:.:  :.|.|     ::|.|::                .:||||
Zfish   677 DDSSQKVNQEVRFQISTEESTFVPVRPISPKPLKPALKRTSVAEKNIEIPTSPHDS--------- 732

  Fly   786 ALGLRHLL-------VINHENRI 801
            ::||::||       |:...|.:
Zfish   733 SMGLKNLLCARPQTDVMEESNNV 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	153/562 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	32/201 (16%)
		CBS repeat	657..763	CDD:341367	18/128 (14%)
		CBS repeat	769..812	CDD:341367	10/56 (18%)
clcn2b	XP_009302317.2	None