DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment garz and gbf1

DIOPT Version :9

Sequence 1:	NP_610761.2	Gene:	garz / 36337	FlyBaseID:	FBgn0264560	Length:	1983	Species:	Drosophila melanogaster
Sequence 2:	XP_031761940.1	Gene:	gbf1 / 100380093	XenbaseID:	XB-GENE-1012128	Length:	1890	Species:	Xenopus tropicalis

Alignment Length:	1967	Identity:	831/1967 - (42%)
Similarity:	1157/1967 - (58%)	Gaps:	248/1967 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IYVVRGEMATLMTAMRRGTRWNATAYVDDENDSLLKLFIDLKHELNRIEDLRQIEPQVFLAPFLE 72
            ||:|:||::.::.|::|..||:....||:|.|.||..|..||..||.|::|.:|||.|||.||||
Frog     6 IYIVQGEISIVVGAIKRNARWSMHTPVDEEQDPLLHSFSVLKEVLNNIKELSEIEPNVFLRPFLE 70

  Fly    73 VIRTADATGPLTSLALASVNKLLSYGLIDPTSPNLADIVERIADAVTHARFMGTDQSSDGVTFMR 137
            |||:.|.|||:|.|||.||||.|||.||||:....|:.:|.:|||||||||:|||.:||.|..|:
Frog    71 VIRSEDTTGPITGLALTSVNKFLSYALIDPSHEGTAEGIENMADAVTHARFVGTDPASDEVVLMK 135

  Fly   138 VIEVLHTLIRSPEGAAVSNVSMCEVMLSCFKISFEPRLSELLRRSAEKSLKDMVLLFFMRLPQFA 202
            :::||.||:.:|.||.::|.|:||:|.|||:|.||.|||||||:|||.:|.|||.|.|.|||||.
Frog   136 ILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFSRLPQFK 200

  Fly   203 EERSD---------------------------------TMLQKRFTIGDAASG---ATQEKLKRK 231
            ||...                                 .:|.|...:...|.|   :::.|.::|
Frog   201 EEAKSYIGTNMKKISPCLLCKMELNSGEQSKNLNQLERVLLFKSLKLKMRAGGMSDSSKWKKQKK 265

  Fly   232 TVAQAQTAPRKSSAVEEPPQTPQSANLTVPGHLKAPILATTPASPAGN--ILDMQGKITQ---TP 291
            :..|.:...:..:|.|...|.|.....|:..:|...:.....:||..|  |..:..:.|.   :|
Frog   266 SPRQPRHVTKAMAAAEPSSQQPVVNGTTITTNLTGEVPFIDASSPDANFPISGVSSEATSAVVSP 330

  Fly   292 TT--------TASTGEDETTV-PETPVI--------------------QVE----------STES 317
            ||        .|::.||.:.: |.:|.:                    ::|          |.||
Frog   331 TTDSGVDMSSQATSKEDLSELDPASPSLSAIQQSGDICLSEQQNQDDDKIEDLMERHTYSASVES 395

  Fly   318 EP-LLDGETGEA-TSTLAEANSSEYINSVGVRFTQQSTDHDVTSLSPYGLPFIQELFRFLIILCN 380
            .| :||.....| .|..|..:..:|:|..||||| ||:..:.|.|.|||||.|:|||||||.|.|
Frog   396 IPEVLDDNVSLADQSDSASVHDMDYVNPRGVRFT-QSSQKEGTVLVPYGLPCIRELFRFLISLTN 459

  Fly   381 PLDKQNSDSMMHTGLSLLTVAFEVAADNIGKYEGLLELVKDDLCRNLISLLSSERLSIFAADLQL 445
            |.|:.||:.|:|.||.|:|||.|.|.  |..|..||.||||:|||:|..|||.|||:::||.|:.
Frog   460 PHDRHNSEVMIHMGLQLITVALESAP--IENYVSLLGLVKDELCRHLFQLLSIERLNLYAASLRA 522

  Fly   446 CFLLFESLRGHLKFQLEAYLRKLSEIIASDNPKTPYEMRELALDNLLQLWRIPGFVTELYINYDC 510
            ||||||.:|.|||||||.|::||.:||..:|||.||||:|:||:.::||||||.|||||||||||
Frog   523 CFLLFEGMREHLKFQLEMYIKKLMDIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDC 587

  Fly   511 DLYCTDMFESLTNLLSKYTLSATNAVYSTHIISMDTLLSVIDSIERNCAASKNSSNNRESLPEAA 575
            |.||:::||.||.||||.....:..:|:||::|::.||:||||.|.:|.| ||.||..:...|..
Frog   588 DYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLEALLTVIDSTESHCQA-KNLSNVSQDKKETG 651

  Fly   576 PATGGSRHSRHNSGLEGIVIDSGNSVAAEEK-----VENIASFINASSH------RLRLQ----- 624
            ..:|.......:||       :.|..:.|.|     .||..|....|.|      .|.:|
Frog   652 KPSGDLSEGTKDSG-------NLNEHSIEVKPFTVSAENNGSKPPTSGHLMADKMTLGVQETEYS 709

  Fly   625 -SGGEGVGITS-----------EQLAKVKQKKRLLSQGTERFNQRPEKGIQYLQEHGILNAELDP 677
             .|||...:..           ::|..:|.||:||..|||:|||:|:||:|:|||..:|...:|.
Frog   710 TDGGEKKTLKKPQRFSCLLPNVQELNDIKTKKKLLITGTEQFNQKPKKGVQFLQEKDLLATPMDN 774

  Fly   678 MQVALFLRENPGLDKKMIGEYISKKKNVDSKILINFVDSFDFTGLRVDQALRLYLETFRLPGEAP 742
            .:||.:|||||.||||||||::|.:||:|  :|.:||.:|.|.|||||:|||||||.||||||||
Frog   775 AEVAQWLRENPRLDKKMIGEFVSDRKNLD--LLESFVGTFHFQGLRVDEALRLYLEAFRLPGEAP 837

  Fly   743 LIFLVLEHFSDHWHKQNQDPFANVDAAFRLAYAIIMLNMDQHNSNAKRLNVPMTLEDFTKNLRGL 807
            :|..:||.|::||.|.|..|||:.||.|.||||:||||.||||.|.::.|||||||:|.|||:|:
Frog   838 VIQRLLEAFTEHWRKSNGTPFAHSDACFALAYAVIMLNTDQHNHNVRKQNVPMTLEEFRKNLKGV 902

  Fly   808 NGGEDFDQEMLAQVFNAIKNEEIVMPAEQTGLVRENYQWKVLLRRGDTHDGHFHYVHDASYDVEI 872
            |||:||||:||..:::||||||||||.||||||:|||.|.|||.||.|.:|.|.:|...|||.::
Frog   903 NGGKDFDQDMLEDIYHAIKNEEIVMPEEQTGLVKENYFWNVLLHRGATPEGMFLHVDPGSYDHDL 967

  Fly   873 FNIVWGASLSALSFMFDKS-TETGYQRTLAGFSKSAAISAHYNLHSDFDALVLTLCKFTTLLSSV 936
            |.:.||.:::|||::|||| .||..|:.::||.|.|.|||||.|...||.|:::|||||||.|..
Frog   968 FTMTWGPTIAALSYVFDKSMDETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTTLSSEA 1032

  Fly   937 EQHEPAPANNETQQAVNFGLNGKAQAAMRTVFLLVHDYGDCLRESWKHILDLYLQLFRLKLLPKS 1001
            .::.|..          ||.|.|||.|.:|||.|.|.:||.|||.||:|:|..|||||.:||||:
Frog  1033 VENLPTV----------FGSNLKAQIAAKTVFHLSHRHGDILREGWKNIMDSMLQLFRAELLPKA 1087

  Fly  1002 LIEVEDFCEANGKAMLILEK-PREKQESGLFSSLYSFIS--------SEGQREPTYEEQDFIKLG 1057
            ::|||||.:.|||..|..|: |..:.|    |::.||:|        ....|.|:.|.|:..||.
Frog  1088 MVEVEDFVDPNGKISLQREEIPANRGE----STVLSFVSWLTLSGTEQSSLRGPSTENQEAKKLA 1148

  Fly  1058 RKCIKECQLDQMLQESKFVQLESLQELLKCVLALLKAPQGHKSIGLPYAEDQTVFWMEFLVKIVV 1122
            .:|||.|..::::.||||:||||||||:|.::::....:       .|.|:...|.:|.|::||:
Frog  1149 LECIKLCDPEKLITESKFLQLESLQELMKALISVTPDEE-------TYDEEDAAFCLEMLMRIVL 1206

  Fly  1123 HNRDRMIPLWPAVRDQMYLLLMGSASCGYDYLLNRCIVAVLKLAIYLMRNEELCPIVLQSLKMLL 1187
            .||||:..:|.||||.:|.|.:.:..  :.:|:.|.:|.:|:|||.|:|.||:...|:.||::||
Frog  1207 ENRDRVGCVWQAVRDHLYRLCVHAVE--FCFLVERAVVGLLRLAIRLLRREEISGQVILSLRILL 1269

  Fly  1188 MLKPALLLRISKQISIGIYELLKTSAQNIHSEQDWQIIFNLLECVGAGAVPPNYDDAQLPLPPNG 1252
            |:||.:|.::|:|::.|::|||||:|.||||..||..:|.||||:|||..||...........:.
Frog  1270 MMKPTVLSKVSRQVAFGVHELLKTNAANIHSSNDWYTLFCLLECIGAGVKPPPALQVTTRADNDT 1334

  Fly  1253 SAKSDGAISGEEDATAVPERGYTSDSEI-----TKASAAPAVSSPSAEN--WILVNNKDSELTTA 1310
            .|:||..:|....:....:||||||||:     .::....:|:.....|  |::|..:|.:.:..
Frog  1335 GAQSDSEVSSYHPSEVNLDRGYTSDSEVYAEHSKQSKMHRSVTDVDMMNSGWLMVGKEDVDSSKV 1399

  Fly  1311 SRPQSPPSLSAPPVNTLVYNCQL-LDHAPF---ALFKCWDSLAFIVRSVAHITPYNFEACVRCIR 1371
            :...:.|..:| |||.  |:..: ||..|.   :|.|..:||:||||..||:||.|||.||:.||
Frog  1400 ATVINKPVANA-PVNQ--YSLTIGLDFGPHDTKSLMKSVESLSFIVRDAAHVTPENFELCVKTIR 1461

  Fly  1372 IFVEACRDGGI---RQRRKLES---AAKQKSSKKRSERKPGMASSASSSNLTLLTGDPSDNQING 1430
            :||||..:||:   .|.:::::   .:|....||:::.|........:||         ..|...
Frog  1462 VFVEASLNGGVWYKSQEKRVKNHKYDSKSNRFKKKTKEKENSVRRTRASN---------QRQYRS 1517

  Fly  1431 NAAEQED--LAQRYEQLSIQ----LLDLMYTLYTRTAQIFRWWAEEGCTVPQSA--------ALW 1481
            ::.::||  :...|..:|:|    |||||:||:||.|.|:..||||...:..:|        .||
Frog  1518 HSDDEEDESVPASYHTVSLQVSHDLLDLMHTLHTRAATIYSSWAEEQRNLETAAEKITADSKTLW 1582

  Fly  1482 SPGWCPLLQGIARLAMDRRREVRTHAISCLQQRALLVHDLQTLSGTEWCSCFHQVLFPLLNELLP 1546
            |..|||||||||.|..|.||:||..|::.| ||||||||||.|...||.|||::||||||.:||.
Frog  1583 SNCWCPLLQGIAWLCCDARRQVRMQALTYL-QRALLVHDLQALDALEWESCFNKVLFPLLTKLLE 1646

  Fly  1547 ESNAAGQLDAALLEESRIRTATIMSKVFLQHLTTLIELGNAFNELWLDILDYIERFMKVG-SDTL 1610
            ..:.|   |...:||:|:|.:|::||||||||:.|:.| :.|..|||.|||:::::|..| ||.|
Frog  1647 NISPA---DVGGMEETRMRGSTLLSKVFLQHLSPLLSL-STFAALWLTILDFMDKYMHAGSSDLL 1707

  Fly  1611 SEQMQEILKNMLLVMHSVRVFHNQDGSLQQA-LWELTWRRIGEFLPNLKEELF-----HDEGKRA 1669
            .|.:.|.||||||||.:..:||:.|.....: |||:||.||..|||.|:||||     .|.....
Frog  1708 PEAIPESLKNMLLVMDTAGIFHSADSRTGYSDLWEITWERIDCFLPRLREELFKQTVIQDPPNIV 1772

  Fly  1670 QTLT----NPAPQAAVAAAPQQQLPAVTILPRQTQVSNELVVSAP---TPPAATPLLGSPVESPR 1727
            .|.|    .|.||:..:..|.:|.|.      .::..:..:.|||   :..:.||:..|||..
Frog  1773 TTETPVEPRPPPQSTQSERPAEQGPC------DSETQSLAISSAPVVGSSSSCTPVRVSPVTD-- 1829

  Fly  1728 RSIILQPPMADVLQQPPSFVFAQPIIVPPQPPAVTDPIPPSTLLPDLVNEATAAAVQATTTSPTH 1792
                :.||:..           .|:|:.|....:...:||.: ||.::|   .|.::||:..|..
Frog  1830 ----IPPPITQ-----------SPVILHPLTSPLQVGVPPMS-LPIILN---PALIEATSPVPLL 1875

  Fly  1793 S-PQEAEQPASIVQQTN 1808
            | |:.|:  .|.|.:.|
Frog  1876 STPRPAD--VSSVSEVN 1890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
garz	NP_610761.2	COG5307	346..>1062	CDD:227623	382/753 (51%)
		Sec7_N	370..512	CDD:289549	90/141 (64%)
		Sec7	643..830	CDD:279680	116/186 (62%)
gbf1	XP_031761940.1	COG5307	442..>1191	CDD:227623	390/781 (50%)
		Sec7	740..925	CDD:396096	116/186 (62%)
		PHA03247	<1753..1886	CDD:223021	41/161 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	629	1.000	Domainoid score	I173
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37897
Inparanoid	1	1.050	1290	1.000	Inparanoid score	I164
OMA	1	1.010	-	-		QHG55524
OrthoDB	1	1.010	-	-		D49474at33208
OrthoFinder	1	1.000	-	-		FOG0003083
OrthoInspector	1	1.000	-	-		oto104498
Panther	1	1.100	-	-	LDO	PTHR10663
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2128
SonicParanoid	1	1.000	-	-		X2055
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110